Treatment of Malignant Brain Tumor by Tumor-Triggered Programmed Wormlike Micelles with Precise Targeting and Deep Penetration

2016 ◽  
Vol 26 (23) ◽  
pp. 4201-4212 ◽  
Author(s):  
Lijuan Zeng ◽  
Lili Zou ◽  
Haijun Yu ◽  
Xinyu He ◽  
Haiqiang Cao ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Malignant Brain Tumor ◽  
Wormlike Micelles ◽  
Deep Penetration

scholarly journals Deleted in malignant brain tumor 1 is secreted in the oviduct and involved in the mechanism of fertilization in equine and porcine species

Reproduction ◽  
2013 ◽  
Vol 146 (2) ◽  
pp. 119-133 ◽  
Author(s):  
Barbara Ambruosi ◽  
Gianluca Accogli ◽  
Cécile Douet ◽  
Sylvie Canepa ◽  
Géraldine Pascal ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Western Blot ◽  
Immunohistochemical Analysis ◽  
Fertilization Rate ◽  
Malignant Brain Tumor ◽  
Estrus Cycle ◽  
Immunofluorescence Analysis ◽  
Oviductal Fluid ◽  
Porcine Spermatozoa

Oviductal environment affects preparation of gametes for fertilization, fertilization itself, and subsequent embryonic development. The aim of this study was to evaluate the effect of oviductal fluid and the possible involvement of deleted in malignant brain tumor 1 (DMBT1) on IVF in porcine and equine species that represent divergent IVF models. We first performed IVF after pre-incubation of oocytes with or without oviductal fluid supplemented or not with antibodies directed against DMBT1. We showed that oviductal fluid induces an increase in the monospermic fertilization rate and that this effect is canceled by the addition of antibodies, in both porcine and equine species. Moreover, pre-incubation of oocytes with recombinant DMBT1 induces an increase in the monospermic fertilization rate in the pig, confirming an involvement of DMBT1 in the fertilization process. The presence of DMBT1 in the oviduct at different stages of the estrus cycle was shown by western blot and confirmed by immunohistochemical analysis of ampulla and isthmus regions. The presence of DMBT1 in cumulus–oocyte complexes was shown by western blot analysis, and the localization of DMBT1 in the zona pellucida and cytoplasm of equine and porcine oocytes was observed using immunofluorescence analysis and confocal microscopy. Moreover, we showed an interaction between DMBT1 and porcine spermatozoa using surface plasmon resonance studies. Finally, a bioinformatic and phylogenetic analysis allowed us to identify the DMBT1 protein as well as a DMBT1-like protein in several mammals. Our results strongly suggest an important role of DMBT1 in the process of fertilization.

scholarly journals The Association of Human Herpesviruses with Malignant Brain Tumor Pathology and Therapy: Two Sides of a Coin

2021 ◽  
Vol 22 (5) ◽  
pp. 2250
Author(s):  
Evita Athanasiou ◽  
Antonios N. Gargalionis ◽  
Fotini Boufidou ◽  
Athanassios Tsakris
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Comprehensive Evaluation ◽  
Tumor Development ◽  
Scientific Data ◽  
Malignant Brain Tumor ◽  
Direct Role ◽  
Tumor Pathology ◽  
Human Herpesviruses

The role of certain viruses in malignant brain tumor development remains controversial. Experimental data demonstrate that human herpesviruses (HHVs), particularly cytomegalovirus (CMV), Epstein–Barr virus (EBV) and human herpes virus 6 (HHV-6), are implicated in brain tumor pathology, although their direct role has not yet been proven. CMV is present in most gliomas and medulloblastomas and is known to facilitate oncomodulation and/or immunomodulation, thus promoting cancer cell proliferation, invasion, apoptosis, angiogenesis, and immunosuppression. EBV and HHV-6 have also been detected in brain tumors and high-grade gliomas, showing high rates of expression and an inflammatory potential. On the other hand, due to the neurotropic nature of HHVs, novel studies have highlighted the engagement of such viruses in the development of new immunotherapeutic approaches in the context of oncolytic viral treatment and vaccine-based strategies against brain tumors. This review provides a comprehensive evaluation of recent scientific data concerning the emerging dual role of HHVs in malignant brain pathology, either as potential causative agents or as immunotherapeutic tools in the fight against these devastating diseases.

scholarly journals Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice

2021 ◽  
Vol 11 (7) ◽  
Author(s):  
David S. Hains ◽  
Shamik Polley ◽  
Dong Liang ◽  
Vijay Saxena ◽  
Samuel Arregui ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Genetic Variation ◽  
Brain Tumor ◽  
Urinary Tract ◽  
Tract Infection ◽  
Infection Risk ◽  
Malignant Brain Tumor

Making the Case for Pediatric Metastatic and Non-Malignant Brain Tumor Surveillance and Research

2015 ◽  
Vol 96 (10) ◽  
pp. e37
Author(s):  
Vincy Chan ◽  
Jason D. Pole ◽  
Robert Mann ◽  
Angela Colantonio
Keyword(s):  
Brain Tumor ◽  
Malignant Brain Tumor ◽  
Tumor Surveillance

scholarly journals STMO-12 Efforts for safe malignant brain tumor surgery at our hospital

2021 ◽  
Vol 3 (Supplement_6) ◽  
pp. vi13-vi13
Author(s):  
Yusuke Kobayashi ◽  
Yosuke Satou ◽  
Takashi Kon ◽  
Daisuke Tanioka ◽  
Katsuyoshi Shimizu ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Pyramidal Tract ◽  
Removal Rate ◽  
Karnofsky Performance Status ◽  
Premotor Cortex ◽  
Performance Status ◽  
Motor Evoked Potential ◽  
Malignant Brain Tumor ◽  
Tumor Surgery ◽  
Brain Tumor Surgery

Abstract Although maximal safe resection is the current standard for glioblastoma surgery, its safety and removal rate conflict with each other. Electrophysiological monitoring, such as motor evoked potential monitoring and awake craniotomy, can be utilized as safety measures; not all facilities can perform them. Herein, we present a representative case report on our efforts for a safe malignant brain tumor surgery. Case: A 77-year-old woman with glioblastoma in the premotor cortex presented with seizure of the upper left lower limb. Her pyramidal tract ran from the medial bottom to the posterior of the tumor. We performed excision from the site using the lowest gamma entropy. We then removed all parts of the tumor, with the exception of the pyramidal tract infiltration, and no paralysis was observed. She was definitively diagnosed with glioblastoma and is currently on maintenance chemotherapy. As a preoperative examination, we performed cerebrovascular angiography. We then performed various other tests to ascertain the patient’s condition. Considering lesions that affect language, Wada tests were performed regardless of laterality. For all patients with epilepsy onset, preoperative 256-channel electroencephalogram measurement and intraoperative the gamma entropy analysis were performed to confirm epileptogenicity. Considering lesions that affect eloquence, subdural electrodes were placed and brain function mapping was performed the next day. Based on the results, the safest cortical incision site and excision range were determined, and excision was performed on the following day. Of the 14 operated glioblastoma cases after November 2018, more than 85% of the contrast-enhanced lesions were completely removed in 7 cases, partially removed in 5 cases, and underwent biopsy in 2 cases. Postoperative Karnofsky performance status scores remained unchanged in 11 cases, improved in 1 case, and deteriorated in 2 cases. Our efforts have resulted in safe and sufficient removal of malignant brain tumors during surgery.

scholarly journals Profile of a Malignant Brain Tumor in Jamaica: an Eight Year Review, 2005 to 2012

2015 ◽  
Author(s):  
P Johnson ◽  
JR Jaggon ◽  
J Campbell ◽  
C Bruce ◽  
D Ferron ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Malignant Brain Tumor

Human non-malignant and malignant brain tumor derived cell cultures: proliferation and sensitivity to natural human fibroblast (beta) interferon

1987 ◽  
Vol 4 (4) ◽  
Author(s):  
AlbertW. Cook ◽  
Florence Nidzgorski ◽  
PhilipR. Roane ◽  
George Mann ◽  
Paul Came ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Cell Cultures ◽  
Human Fibroblast ◽  
Malignant Brain Tumor ◽  
Beta Interferon
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