Thiolation and Cell-Penetrating Peptide Surface Functionalization of Porous Silicon Nanoparticles for Oral Delivery of Insulin

2016 ◽  
Vol 26 (20) ◽  
pp. 3405-3416 ◽  
Author(s):  
Neha Shrestha ◽  
Francisca Araújo ◽  
Mohammad-Ali Shahbazi ◽  
Ermei Mäkilä ◽  
Maria João Gomes ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Surface Functionalization ◽  
Oral Delivery ◽  
Silicon Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Porous Silicon Nanoparticles

scholarly journals Systematic Degradation Rate Analysis of Surface-Functionalized Porous Silicon Nanoparticles

Materials ◽  
2019 ◽  
Vol 12 (4) ◽  
pp. 580 ◽  
Author(s):  
Rae Kang ◽  
Seo Lee ◽  
Sangrim Kang ◽  
Jinyoung Kang ◽  
Junho Hur ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Surface Functionalization ◽  
Biomedical Applications ◽  
Degradation Rate ◽  
Silicon Nanoparticles ◽  
Brain Heart Infusion ◽  
Biological Media ◽  
Rate Analysis ◽  
Biological Studies ◽  
Porous Silicon Nanoparticles

Porous silicon nanoparticles (pSiNPs) have been utilized within a wide spectrum of biological studies, as well as in chemistry, chemical biology, and biomedical fields. Recently, pSiNPs have been constantly coming under the spotlight, mostly in biomedical applications, due to their advantages, such as controlled-release drug delivery in vivo by hydrolysis-induced degradation, self-reporting property through long life-time photoluminescence, high loading efficiency of substrate into pore, and the homing to specific cells/organ/bacteria by surface functionalization. However, the systematic degradation rate analysis of surface-functionalized pSiNPs in different biological media has not been conducted yet. In this paper, we prepared four different surface-functionalized pSiNPs samples and analyzed the degradation rate in six different media (DI H2O (deionized water), PBS (phosphate-buffered saline), HS (human serum), DMEM (Dulbecco’s modified Eagle’s medium), LB (lysogeny broth), and BHI (brain heart infusion)). The obtained results will now contribute to understanding the correlation between surface functionalization in the pSiNPs and the degradation rate in different biological media. The characterized data with the author’s suggestions will provide useful insights in designing the new pSiNPs formulation for biomedical applications.

Fusogenic porous silicon nanoparticles as a broad-spectrum immunotherapy against bacterial infections

2021 ◽  
Author(s):  
Byungji Kim ◽  
Qinglin Yang ◽  
Leslie W. Chan ◽  
Sangeeta N. Bhatia ◽  
Erkki Ruoslahti ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Broad Spectrum ◽  
Therapeutic Efficacy ◽  
Bacterial Infections ◽  
Silicon Nanoparticles ◽  
First Line ◽  
Gram Positive ◽  
Gram Negative ◽  
Porous Silicon Nanoparticles

RNAi-mediated immunotherapy provided by fusogenic porous silicon nanoparticles demonstrates superior therapeutic efficacy against both Gram-positive and Gram-negative bacterial infections compared with first-line antibiotics.

Porous Silicon–Cell Penetrating Peptide Hybrid Nanocarrier for Intracellular Delivery of Oligonucleotides

2013 ◽  
Vol 11 (2) ◽  
pp. 382-390 ◽  
Author(s):  
Jussi Rytkönen ◽  
Piret Arukuusk ◽  
Wujun Xu ◽  
Kaido Kurrikoff ◽  
Ülo Langel ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Silicon Cell
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