Linear Dendritic Block Copolymers as Promising Biomaterials for the Manufacturing of Soft Tissue Adhesive Patches Using Visible Light Initiated Thiol-Ene Coupling Chemistry

2015 ◽  
Vol 25 (42) ◽  
pp. 6596-6605 ◽  
Author(s):  
Viktor Granskog ◽  
Oliver C. J. Andrén ◽  
Yanling Cai ◽  
Marcela González-Granillo ◽  
Li Felländer-Tsai ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Block Copolymers ◽  
Visible Light ◽  
Tissue Adhesive

scholarly journals β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive

2021 ◽  
Vol 22 (2) ◽  
pp. 700
Author(s):  
Young Jae Moon ◽  
Sun-Jung Yoon ◽  
Jeung-Hyun Koo ◽  
Yihyun Yoon ◽  
Hye Jun Byun ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bacterial Infection ◽  
Visible Light ◽  
Visible Light Irradiation ◽  
Light Irradiation ◽  
Tissue Adhesive ◽  
Proton Nuclear Magnetic Resonance ◽  
Scanning Calorimetry ◽  
Glycol Chitosan

Accelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated methacrylated glycol chitosan (MGC) as an antibacterial tissue adhesive. Proton nuclear magnetic resonance (1H NMR) and differential scanning calorimetry (DSC) results showed the inclusion complex formation between MGC-g-CD and TCS. The increase of storage modulus (G’) of MGC-g-CD-ic-TCS after visible light irradiation for 200 s indicated its hydrogelation. The swollen hydrogel in aqueous solution resulted in two release behaviors of an initial burst and sustained release. Importantly, in vitro and in vivo results indicated that MGC-g-CD-ic-TCS inhibited bacterial infection and improved wound healing, suggesting its high potential application as an antibacterial tissue bio-adhesive.

Visible light-induced iniferter polymerization of methacrylates enhanced by continuous flow

2017 ◽  
Vol 8 (42) ◽  
pp. 6496-6505 ◽  
Author(s):  
Maarten Rubens ◽  
Phanumat Latsrisaeng ◽  
Tanja Junkers
Keyword(s):  
Block Copolymers ◽  
Visible Light ◽  
Continuous Flow ◽  
Flow Reactors ◽  
Continuous Flow Reactors

Visible-light induced photoiniferter polymerization in continuous flow reactors is very efficient in yielding low dispersity methacrylate block copolymers.

Facile synthesis of poly(N-vinyl pyrrolidone) block copolymers with “more-activated” monomers by using photoinduced successive RAFT polymerization

2020 ◽  
Vol 11 (12) ◽  
pp. 2080-2088
Author(s):  
Yingjie Wang ◽  
Mengqi Wang ◽  
Liangjiu Bai ◽  
Lifen Zhang ◽  
Zhenping Cheng ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Visible Light ◽  
Room Temperature ◽  
Raft Polymerization ◽  
Vinyl Pyrrolidone ◽  
Facile Synthesis ◽  
Polymerization Method

Well-defined PNVP block copolymers with more-activated monomers were synthesized by a single RAFT polymerization method under irradiation with visible light at room temperature.

Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping

2012 ◽  
Vol 529-530 ◽  
pp. 543-546
Author(s):  
Mariko Nakamura ◽  
Yasuhiro Yoshida ◽  
Yoshihiro Ito
Keyword(s):  
Soft Tissue ◽  
Visible Light ◽  
Dental Pulp ◽  
Dental Materials ◽  
Direct Pulp Capping ◽  
Hard Tissue ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Dental Pulp Tissue

Direct pulp capping involves the application of dental materials to the exposed pulp in an attempt to act as a barrier, protect the dental pulp complex and preserve its vitality. The materials for direct pulp capping should ideally adhere to dental pulp tissue as soft tissue and dentin as hard tissue with tight sealing. We therefore developed visible light-induced crosslinkable gelatin which is capable of adhesive to soft tissue and hard tissue.

scholarly journals Adhesive Cements That Bond Soft Tissue Ex Vivo

Materials ◽  
2019 ◽  
Vol 12 (15) ◽  
pp. 2473 ◽  
Author(s):  
Xiuwen Liu ◽  
Michael Pujari-Palmer ◽  
David Wenner ◽  
Philip Procter ◽  
Gerard Insley ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Ex Vivo ◽  
Tissue Adhesive ◽  
Wet Milling ◽  
Tissue Adhesives ◽  
Porcine Skin ◽  
Lap Shear ◽  
Bond Strengths ◽  
Calcified Tissues

The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (αTCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. αTCP PMCs reached a final LSS of ≈110 kPa. In soft tissues, stronger bond strengths were obtained with αTCP PMCs containing large amounts of amino acid (70–90 mol%), in contrast to prior studies in calcified tissues (30–50 mol%). When αTCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30–50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues.

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