Triphenylphosphonium-Conjugated Poly(ε-caprolactone)-Based Self-Assembled Nanostructures as Nanosized Drugs and Drug Delivery Carriers for Mitochondria-Targeting Synergistic Anticancer Drug Delivery

2015 ◽  
Vol 25 (34) ◽  
pp. 5479-5491 ◽  
Author(s):  
Dong Youl Cho ◽  
Hana Cho ◽  
Kiyoon Kwon ◽  
Minjong Yu ◽  
Eunji Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Self Assembled ◽  
Mitochondria Targeting

Novel self-assembled amphiphilic mPEGylated starch-deoxycholic acid polymeric micelles with pH-response for anticancer drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (98) ◽  
pp. 55139-55149 ◽  
Author(s):  
Jinlong Yang ◽  
Chunmei Gao ◽  
Shaoyu Lü ◽  
Xinggang Wang ◽  
Mingjia Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Deoxycholic Acid ◽  
Polymeric Micelles ◽  
Anticancer Drug Delivery ◽  
Ph Response ◽  
Self Assembled

scholarly journals PLLA-Grafted Gelatin Amphiphilic Copolymer and Its Self-Assembled Nano Carrier for Anticancer Drug Delivery

2019 ◽  
Vol 220 (5) ◽  
pp. 1800528 ◽  
Author(s):  
Du Beibei ◽  
Fan Tiantang ◽  
Li Jiafeng ◽  
Gong Li ◽  
Zhang Qin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Amphiphilic Copolymer ◽  
Anticancer Drug Delivery ◽  
Self Assembled

Dual thermoresponsive and pH-responsive self-assembled micellar nanogel for anticancer drug delivery

Drug Delivery ◽  
2013 ◽  
Vol 21 (4) ◽  
pp. 258-264 ◽  
Author(s):  
Daquan Chen ◽  
Hongyun Yu ◽  
Kaoxiang Sun ◽  
Wanhui Liu ◽  
Hongbo Wang
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Ph Responsive ◽  
Anticancer Drug Delivery ◽  
Self Assembled

Injectable and Thermoresponsive Self-Assembled Nanocomposite Hydrogel for Long-Term Anticancer Drug Delivery

Langmuir ◽  
2013 ◽  
Vol 29 (11) ◽  
pp. 3721-3729 ◽  
Author(s):  
Ying-Yu Chen ◽  
Hsi-Chin Wu ◽  
Jui-Sheng Sun ◽  
Guo-Chung Dong ◽  
Tzu-Wei Wang
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Nanocomposite Hydrogel ◽  
Anticancer Drug Delivery ◽  
Self Assembled

scholarly journals Self-Assembled Supramolecular Ribbon-Like Structures Complexed to Single Walled Carbon Nanotubes as Possible Anticancer Drug Delivery Systems

2019 ◽  
Vol 20 (9) ◽  
pp. 2064 ◽  
Author(s):  
Anna Jagusiak ◽  
Katarzyna Chłopaś ◽  
Grzegorz Zemanek ◽  
Małgorzata Jemioła-Rzemińska ◽  
Barbara Piekarska ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Anticancer Drug ◽  
Triple System ◽  
Single Walled Carbon Nanotubes ◽  
Drug Binding ◽  
Single Walled Carbon ◽  
Anticancer Drug Delivery ◽  
Self Assembled ◽  
Walled Carbon Nanotubes

Designing an effective targeted anticancer drug delivery method is still a big challenge, since chemotherapeutics often cause a variety of undesirable side effects affecting normal tissues. This work presents the research on a novel system consisting of single walled carbon nanotubes (SWNT), dispersed with Congo Red (CR), a compound that forms self-assembled ribbon-like structures (SRLS) and anticancer drug doxorubicin (DOX). SWNT provide a large surface for binding of planar aromatic compounds, including drugs, while CR supramolecular ribbon-like assemblies can be intercalated by drugs, like anthracycline rings containing DOX. The mechanism of interactions in SWNT–CR–DOX triple system was proposed based on electrophoretic, spectral, Dynamic Light Scattering and scanning electron microscopy analyzes. The profile of drug release from the investigated system was evaluated using dialysis and Differential Scanning Calorimetry. The results indicate that ribbon-like supramolecular structures of CR bind to SWNT surface forming SWNT–CR complexes which finally bind DOX. The high amount of nanotube-bound CR greatly increases the capacity of the carrier for the drug. The high capacity for drug binding and possible control of its release (through pH changes) in the analyzed system may result in prolonged and localized drug action. The proposed SWNT–CR–DOX triple system meets the basic criteria that justifies its further research as a potential drug carrier.

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