scholarly journals Iron Oxide-Labeled Collagen Scaffolds for Non-Invasive MR Imaging in Tissue Engineering

2013 ◽  
Vol 24 (6) ◽  
pp. 754-762 ◽  
Author(s):  
Marianne E. Mertens ◽  
Alina Hermann ◽  
Anne Bühren ◽  
Leon Olde-Damink ◽  
Diana Möckel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Collagen Scaffolds ◽  
Non Invasive

scholarly journals Collagen Scaffolds: Iron Oxide-Labeled Collagen Scaffolds for Non-Invasive MR Imaging in Tissue Engineering (Adv. Funct. Mater. 6/2014)

2014 ◽  
Vol 24 (6) ◽  
pp. 722-722
Author(s):  
Marianne E. Mertens ◽  
Alina Hermann ◽  
Anne Bühren ◽  
Leon Olde-Damink ◽  
Diana Möckel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Collagen Scaffolds ◽  
Non Invasive

scholarly journals FMN-Coated Fluorescent USPIO for Cell Labeling and Non-Invasive MR Imaging in Tissue Engineering

Theranostics ◽  
2014 ◽  
Vol 4 (10) ◽  
pp. 1002-1013 ◽  
Author(s):  
Marianne E. Mertens ◽  
Julia Frese ◽  
Deniz Ali Bölükbas ◽  
Ladislav Hrdlicka ◽  
Susanne Golombek ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mr Imaging ◽  
Cell Labeling ◽  
Non Invasive

scholarly journals IL-6-targeted ultrasmall superparamagnetic iron oxide nanoparticles for optimized MRI detection of atherosclerotic vulnerable plaques in rabbits

RSC Advances ◽  
2020 ◽  
Vol 10 (26) ◽  
pp. 15346-15353
Author(s):  
Huaqiang Mo ◽  
Chenxing Fu ◽  
Zhiye Wu ◽  
Peng Liu ◽  
Zhibo Wen ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Invasive Strategy ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Non Invasive ◽  
Vulnerable Plaques ◽  
Inflammatory Macrophages

Herein, we report Anti-IL-6-USPIO for detecting IL-6 in inflammatory macrophages and MR imaging vulnerable plaques of atherosclerosis in rabbit, which would provide a novel non-invasive strategy for evaluating acute cardiovascular risk or exploiting anti-atherosclerotic drugs.

Non-invasive detection of liver fibrosis: Is superparamagnetic iron oxide particle-enhanced MR imaging a contributive technique?

2003 ◽  
Vol 13 (3) ◽  
pp. 467-474 ◽  
Author(s):  
Olivier Lucidarme ◽  
Florence Baleston ◽  
Mehdi Cadi ◽  
Marie-France Bellin ◽  
Frédéric Charlotte ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Liver Fibrosis ◽  
Mr Imaging ◽  
Oxide Particle ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Particle ◽  
Non Invasive

scholarly journals Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2337
Author(s):  
Ralf P. Friedrich ◽  
Iwona Cicha ◽  
Christoph Alexiou
Keyword(s):  
Tissue Engineering ◽  
Iron Oxide ◽  
Regenerative Medicine ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Specific Cell ◽  
Non Invasive ◽  
Observation Methods ◽  
Therapeutic Compounds ◽  
Kidney Liver

In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

Iron-Oxide Nanocluster Labeling of Clostridium novyi-NT Spores for MR Imaging–Monitored Locoregional Delivery to Liver Tumors in Rat and Rabbit Models

2019 ◽  
Vol 30 (7) ◽  
pp. 1106-1115.e1
Author(s):  
Jingran Ji ◽  
Woo Ram Park ◽  
Soojeong Cho ◽  
Yihe Yang ◽  
Weiguo Li ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Liver Tumors ◽  
Clostridium Novyi

Surface-Directed Mineralization of Fibrous Collagen Scaffolds in Simulated Body Fluid for Tissue Engineering Applications

2021 ◽  
Vol 4 (3) ◽  
pp. 2514-2522
Author(s):  
Odair Bim-Júnior ◽  
Fabiana Curylofo-Zotti ◽  
Mariana Reis ◽  
Yvette Alania ◽  
Paulo N. Lisboa-Filho ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Collagen Scaffolds ◽  
Engineering Applications

scholarly journals Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 995
Author(s):  
Yucheng Peng ◽  
Xiaomeng Wang ◽  
Yue Wang ◽  
Yue Gao ◽  
Rui Guo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Pamam Dendrimer ◽  
Great Promise ◽  
Oxide Nanoparticles ◽  
Dual Mode ◽  
Gold Nanoflowers ◽  
Average Size

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

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