Surface Modification of Exfoliated Layered Gadolinium Hydroxide for the Development of Multimodal Contrast Agents for MRI and Fluorescence Imaging

2009 ◽  
Vol 19 (21) ◽  
pp. 3375-3380 ◽  
Author(s):  
Young-su Yoon ◽  
Byung-Il Lee ◽  
Kyung Sig Lee ◽  
Geun Ho Im ◽  
Song-Ho Byeon ◽  
...  
Author(s):  
Jonghoon Kim ◽  
Nohyun Lee ◽  
Taeghwan Hyeon

Molecular imaging enables us to non-invasively visualize cellular functions and biological processes in living subjects, allowing accurate diagnosis of diseases at early stages. For successful molecular imaging, a suitable contrast agent with high sensitivity is required. To date, various nanoparticles have been developed as contrast agents for medical imaging modalities. In comparison with conventional probes, nanoparticles offer several advantages, including controllable physical properties, facile surface modification and long circulation time. In addition, they can be integrated with various combinations for multimodal imaging and therapy. In this opinion piece, we highlight recent advances and future perspectives of nanomaterials for molecular imaging. This article is part of the themed issue ‘Challenges for chemistry in molecular imaging’.


2014 ◽  
Vol 20 (3) ◽  
pp. 67-80 ◽  
Author(s):  
Bingbing Cheng ◽  
Ming-Yuan Wei ◽  
Yuan Liu ◽  
Harish Pitta ◽  
Zhiwei Xie ◽  
...  

Author(s):  
Pascal Gschwend ◽  
Kerda Keevend ◽  
Marianne Aellen ◽  
Alexander Gogos ◽  
Frank Krumeich ◽  
...  

Deep-tissue fluorescence imaging remains a major challenge as there is limited availability of bright biocompatible materials with high photo- and chemical stability. Contrast agents with emission wavelengths above 1000 nm...


2014 ◽  
Vol 2 (42) ◽  
pp. 7394-7402 ◽  
Author(s):  
Weiqin Sheng ◽  
Jing Liu ◽  
Shanshan Liu ◽  
Qiang Lu ◽  
David L. Kaplan ◽  
...  

Core–shell Fe3O4/SF nanoparticles, prepared by silk fibroin in one step, could be widely used in biomedical areas, such as contrast agents and targets with some surface modification.


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