Temperature-Induced Hydrogels Through Self-Assembly of Cholesterol-Substituted Star PEG-b-PLLA Copolymers: An Injectable Scaffold for Tissue Engineering

2008 ◽  
Vol 18 (8) ◽  
pp. 1220-1231 ◽  
Author(s):  
Koji Nagahama ◽  
Tatsuro Ouchi ◽  
Yuichi Ohya
Keyword(s):  
Tissue Engineering ◽  
Self Assembly ◽  
Injectable Scaffold

scholarly journals The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

2021 ◽  
Author(s):  
Marissa Morales-Moctezuma ◽  
Sebastian G Spain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

scholarly journals Review: The Self-Assembly Approach for Organ Reconstruction by Tissue Engineering

2000 ◽  
Vol 1 (5) ◽  
pp. 75-86 ◽  
Author(s):  
F.A. Auger ◽  
M. Rémy-Zolghadri ◽  
G. Grenier ◽  
L. Germain
Keyword(s):  
Tissue Engineering ◽  
Self Assembly ◽  
The Self

Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽  
2021 ◽  
Author(s):  
Michael Meleties ◽  
Priya Katyal ◽  
Bonnie Lin ◽  
Dustin Britton ◽  
Jin Kim Montclare
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Coiled Coil ◽  
Stimuli Responsive ◽  
Tunable Properties ◽  
Stimuli Sensitive ◽  
Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

Macromolecular Crowding Meets Tissue Engineering by Self-Assembly: A Paradigm Shift in Regenerative Medicine

2014 ◽  
Vol 26 (19) ◽  
pp. 3024-3034 ◽  
Author(s):  
Abhigyan Satyam ◽  
Pramod Kumar ◽  
Xingliang Fan ◽  
Alexander Gorelov ◽  
Yury Rochev ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Self Assembly ◽  
Paradigm Shift ◽  
Macromolecular Crowding

Self-Assembly of Fibrochondrocytes and Chondrocytes for Tissue Engineering of the Knee Meniscus

2007 ◽  
Vol 13 (5) ◽  
pp. 939-946 ◽  
Author(s):  
Gwendolyn M. Hoben ◽  
Jerry C. Hu ◽  
Regis A. James ◽  
Kyriacos A. Athanasiou
Keyword(s):  
Tissue Engineering ◽  
Self Assembly ◽  
Knee Meniscus

Thermosensitive and Cell-Adhesive Pluronic Hydrogels for Human Adipose-Derived Stem Cells

2007 ◽  
Vol 342-343 ◽  
pp. 301-304 ◽  
Author(s):  
Kwi Deok Park ◽  
Hong Hee Jung ◽  
Jun Sik Son ◽  
Jong Won Rhie ◽  
Ki Dong Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Pluronic F127 ◽  
Peptide Ligand ◽  
Temperature Sensitive ◽  
Adipose Derived Stem Cells ◽  
Chemical Structures ◽  
Injectable Scaffold ◽  
Cell Adhesive ◽  
Critical Micelle Temperature

Pluronic F127 has received increasing attention over many years as drug delivery systems, biomaterials, and hydrogels for tissue engineering. In this study, we synthesized temperature-sensitive and cell-adhesive triblock F127 copolymers, in which Arg-Gly-Asp (RGD) peptide ligand was grafted to Pluronic F127-4-methacryloxyethyl trimellitic anhydride (4-META) to obtain F127-META-RGD. The chemical structures of the F127-META-RGD block copolymers were confirmed by FTIR, 1H and 13C NMR, and GPC. The resultant F127-META-RGD showed very similar thermosensitive behaviors to F127 and F127-META. The critical micelle temperature (CMT) of the F127 copolymers decreased in the order of F127 < F127-META < F127-META-RGD, whereas the particle size followed an opposite trend. Interactions between the F127 copolymers and adipose-derived stem cells (ASC) were evaluated in terms of cell adhesion and proliferation on the hydrogel. These thermosensitive RGD-grafted Pluronic hydrogels that display the enhanced cell adhesiveness, are expected to be useful as a functional injectable scaffold for tissue engineering.

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