Advances in Targeted Therapy and Immunotherapy for Pancreatic Cancer

2021 ◽  
pp. 1900236
Author(s):  
Xiaoxiao Liu ◽  
Zhang Li ◽  
Yuexiang Wang
Keyword(s):  
Pancreatic Cancer ◽  
Targeted Therapy

scholarly journals The Promising Role of TGF- β/SMAD4 in Pancreatic Cancer: The future targeted therapy

2019 ◽  
Vol 3 (2) ◽  
pp. 1-7
Author(s):  
Sunjida Ahmed ◽  
Christopher Schwartz ◽  
M Dewan ◽  
Ruliang Xu
Keyword(s):  
Pancreatic Cancer ◽  
Targeted Therapy ◽  
The Future

Targeted therapy of pancreatic cancer: biomarkers are needed

2017 ◽  
Vol 18 (4) ◽  
pp. 421-422 ◽  
Author(s):  
Jörg Kleeff ◽  
Patrick Michl
Keyword(s):  
Pancreatic Cancer ◽  
Targeted Therapy ◽  
Cancer Biomarkers

scholarly journals Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy

2020 ◽  
Vol 13 (3) ◽  
pp. 1239-1243
Author(s):  
Shenthol Sasankan ◽  
Lorraine Rebuck ◽  
Gloria Darrah ◽  
Moises Harari Turquie ◽  
Ian Rabinowitz
Keyword(s):  
Pancreatic Cancer ◽  
Case Report ◽  
Targeted Therapy ◽  
Therapeutic Response ◽  
Case Reports ◽  
Clinical History ◽  
P53 Mutation ◽  
Metastatic Pancreatic Cancer ◽  
First Case ◽  
History Of

We report on the clinical history of a 49-year-old female with metastatic pancreatic cancer. She was initially treated with standard chemotherapy as per current guidelines. She was found to have both a BRAF and P53 mutation, and received dabrafenib and trametinib with deep responses, both radiographically and biochemically (CA19-9). Her response has been more clinically relevant than responses in previous case reports of patients with BRAF-positive pancreatic cancer treated with targeted therapy. To the best of our knowledge, this is the first case report showing a dramatic therapeutic response to combination therapy with dabrafenib and trametinib in metastatic pancreatic cancer.

scholarly journals Endoscopic Ultrasound-Guided Therapies in Pancreatic Neoplasms

2015 ◽  
Vol 2015 ◽  
pp. 1-12
Author(s):  
Dennis Yang ◽  
Christopher J. DiMaio
Keyword(s):  
Pancreatic Cancer ◽  
Targeted Therapy ◽  
Endoscopic Ultrasound ◽  
Pancreatic Neoplasms ◽  
Ultrasound Guided ◽  
Poor Survival ◽  
Minimally Invasive Approach ◽  
Diagnostic Modality ◽  
Invasive Approach ◽  
Guided Therapy

Endoscopic ultrasound (EUS) has evolved from being primarily a diagnostic modality into an interventional endoscopic tool for the management of both benign and malignant gastrointestinal illnesses. EUS-guided therapy has garnered particular interest as a minimally invasive approach for the treatment of pancreatic cancer, a disease often complicated by its aggressive course and poor survival. The potential advantage of an EUS-guided approach revolves around real-time imaging for targeted therapy of a difficult to reach organ. In this review, we focus on EUS-guided therapies for pancreatic neoplasms.

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