Cluster Recognition by Delaunay Triangulation of Synaptic Proteins in 3D

2017 ◽  
Vol 1 (10) ◽  
pp. 1700091 ◽  
Author(s):  
Daniel Boening ◽  
Anne Gauthier-Kemper ◽  
Benjamin Gmeiner ◽  
Jürgen Klingauf
Keyword(s):  
Delaunay Triangulation ◽  
Synaptic Proteins ◽  
Cluster Recognition

The photoreceptor cytoskeleton visualized

1992 ◽  
Vol 50 (1) ◽  
pp. 480-481
Author(s):  
Beth Burnside
Keyword(s):  
Outer Segment ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Cell Polarization ◽  
Synaptic Proteins ◽  
Cell Functions ◽  
Vertebrate Photoreceptor ◽  
Numerous Cell ◽  
Turn Over

The vertebrate photoreceptor provides a drammatic example of cell polarization. Specialized to carry out phototransduction at its distal end and to synapse with retinal interneurons at its proximal end, this long slender cell has a uniquely polarized morphology which is reflected in a similarly polarized cytoskeleton. Membranes bearing photopigment are localized in the outer segment, a modified sensory cilium. Sodium pumps which maintain the dark current critical to photosensory transduction are anchored along the inner segment plasma membrane between the outer segment and the nucleus.Proximal to the nucleus is a slender axon terminating in specialized invaginating synapses with other neurons of the retina. Though photoreceptor diameter is only 3-8u, its length from the tip of the outer segment to the synapse may be as great as 200μ. This peculiar linear cell morphology poses special logistical problems and has evoked interesting solutions for numerous cell functions. For example, the outer segment membranes turn over by means of a unique mechanism in which new disks are continuously added at the proximal base of the outer segment, while effete disks are discarded at the tip and phagocytosed by the retinal pigment epithelium. Outer segment proteins are synthesized in the Golgi near the nucleus and must be transported north through the inner segment to their sites of assembly into the outer segment, while synaptic proteins must be transported south through the axon to the synapse.The role of the cytoskeleton in photoreceptor motile processes is being intensely investigated in several laboratories.

The effect of acute immobilization stress on the expression of synaptic proteins in serotonin transporter deficient mice

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
SL Nietzer ◽  
AG Schmitt ◽  
G Ortega ◽  
C Kriegebaum ◽  
L Gutknecht ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Immobilization Stress ◽  
Synaptic Proteins ◽  
Deficient Mice

Numerical implementation of finite-element method of control volume using irregular mesh

2010 ◽  
Vol 7 ◽  
pp. 98-108
Author(s):  
Yu.A. Gafarova
Keyword(s):  
Finite Element Method ◽  
Finite Element ◽  
Delaunay Triangulation ◽  
Complex Geometry ◽  
Control Volume ◽  
Test Case ◽  
The Finite Element Method ◽  
Irregular Mesh ◽  
Discrete Analogues ◽  
Element Method

To solve problems with complex geometry it is considered the possibility of application of irregular mesh and the use of various numerical methods using them. Discrete analogues of the Beltrami-Mitchell equations are obtained by the control volume method using the rectangular grid and the finite element method of control volume using the Delaunay triangulation. The efficiency of using the Delaunay triangulation, Voronoi diagrams and the finite element method of control volume in a test case is demonstrated.

mTORC and PKCε in Regulation of Alcohol Use Disorder

2020 ◽  
Vol 20 (17) ◽  
pp. 1696-1708 ◽  
Author(s):  
Athirah Hanim ◽  
Isa Naina Mohamed ◽  
Rashidi M. Pakri Mohamed ◽  
Srijit Das ◽  
Norefrina Shafinaz Md Nor ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Alcohol Intake ◽  
Potential Role ◽  
Synaptic Proteins ◽  
Cellular Mechanisms ◽  
Kinase C ◽  
Protein Kinase C Epsilon ◽  
Seeking Behavior

Alcohol use disorder (AUD) is characterized by compulsive binge alcohol intake, leading to various health and social harms. Protein Kinase C epsilon (PKCε), a specific family of PKC isoenzyme, regulates binge alcohol intake, and potentiates alcohol-related cues. Alcohol via upstream kinases like the mammalian target to rapamycin complex 1 (mTORC1) or 2 (mTORC2), may affect the activities of PKCε or vice versa in AUD. mTORC2 phosphorylates PKCε at hydrophobic and turn motif, and was recently reported to be associated with alcohol-seeking behavior, suggesting the potential role of mTORC2-PKCε interactions in the pathophysiology of AUD. mTORC1 regulates translation of synaptic proteins involved in alcohol-induced plasticity. Hence, in this article, we aimed to review the molecular composition of mTORC1 and mTORC2, drugs targeting PKCε, mTORC1, and mTORC2 in AUD, upstream regulation of mTORC1 and mTORC2 in AUD and downstream cellular mechanisms of mTORCs in the pathogenesis of AUD.

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