Update on new boxed warning for benzodiazepines

2021 ◽  
Vol 33 (8) ◽  
pp. 6-7
Author(s):  
Alison Knopf
Keyword(s):  
Boxed Warning

Panels Reject Suicidality Boxed Warning for AEDs

2008 ◽  
Vol 41 (14) ◽  
pp. 7
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Boxed Warning

FDA Asks for Boxed Warning On Xolair Label

2007 ◽  
Vol 37 (7) ◽  
pp. 6
Author(s):  
Nancy Walsh
Keyword(s):  
Boxed Warning

scholarly journals The role of leukotriene modifying agent treatment in neuropsychiatric events of elderly asthma patients: a nested case control study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sang Oh Kang ◽  
Kyung Hyun Min ◽  
Hyun Jeong Kim ◽  
Tae Hyeok Kim ◽  
Woorim Kim ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Boxed Warning ◽  
Control Group ◽  
Case Group ◽  
Newly Diagnosed ◽  
Crude Odds Ratio ◽  
Asthma Patients ◽  
Nested Case Control ◽  
Control Study

Abstract Background In March 2020, the US Food and Drug Administration decided that the dangers related to neuropsychiatric events (NPEs) of montelukast, one of the leukotriene modifying agents (LTMAs), should be communicated through ‘boxed warning’. In case of NPEs, the prevalence has been the highest in elderly people. Because the characteristics of the elderly such as old age itself can act as risk factors. Therefore, an investigation on safety of LTMAs related to NPEs in elderly using LTMAs is needed. Method A nested case-control study using an elderly sample cohort from the Korean National Health Insurance Service database was used. The asthma cohort included asthma patients newly diagnosed between 2003 and 2013. Within the asthma cohort, the case group was defined as patients who were diagnosed with NPEs. Among patients who had never been diagnosed with NPEs, the control group was selected by matching 1:1 by propensity score. Patients who were prescribed LTMAs for 1 year prior to index date were defined as the exposure group. The logistic regression model was used to measure the effect of LTMAs on NPEs. Results We identified 141,165 patients with newly diagnosed asthma, and selected 31,992 patients per each case and control group. Exposure to LTMAs significantly increased the risk of overall NPEs about in comparison with the absence of exposure (crude odds ratio [OR] 1.58, 95% CI 1.50–1.68). After adjusting for confounding factors, the overall NPEs risk increased (adjusted OR, 1.67, 95% CI 1.58–1.78). Conclusion This study suggests that elderly asthma patients prescribed LTMAs had a higher risk of NPEs than patients who were not treated with LTMAs. Therefore, clinicians should be aware of the potential risks of LTMAs.

Otolaryngology practice patterns in pediatric tonsillectomy: The impact of the codeine boxed warning

2017 ◽  
Vol 128 (1) ◽  
pp. 264-268 ◽  
Author(s):  
Julie L. Goldman ◽  
Craig Ziegler ◽  
Elizabeth M. Burckardt
Keyword(s):  
Practice Patterns ◽  
Boxed Warning ◽  
The Impact

New boxed warning required for 'Seldane'

1992 ◽  
Vol &NA; (412) ◽  
pp. 3
Author(s):  
&NA;
Keyword(s):  
Boxed Warning
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