Compartmental modelling of the uptake kinetics of the anti-cancer agent topotecan in human breast cancer cells

2005 ◽  
Vol 19 (5) ◽  
pp. 395-417 ◽  
Author(s):  
Neil D. Evans ◽  
Rachel J. Errington ◽  
Michael J. Chapman ◽  
Paul J. Smith ◽  
Michael J. Chappell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Compartmental Modelling ◽  
Anti Cancer ◽  
Cancer Agent ◽  
Kinetics Of

scholarly journals Benzene-Poly-Carboxylic Acid Complex, a Novel Anti-Cancer Agent Induces Apoptosis in Human Breast Cancer Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e85156 ◽  
Author(s):  
Fuad Fares ◽  
Naiel Azzam ◽  
Basem Fares ◽  
Stig Larsen ◽  
Steen Lindkaer-Jensen
Keyword(s):  
Breast Cancer ◽  
Carboxylic Acid ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Acid Complex ◽  
Anti Cancer ◽  
Cancer Agent

scholarly journals CK0403, a 9-aminoacridine, is a potent anti-cancer agent in human breast cancer cells

2015 ◽  
Vol 13 (1) ◽  
pp. 933-938 ◽  
Author(s):  
YUAN-WAN SUN ◽  
KUEN-YUAN CHEN ◽  
CHUL-HOON KWON ◽  
KUN-MING CHEN
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Anti Cancer ◽  
Cancer Agent

Effects of 1,25-dihydroxyvitamin D3 on cell-cycle kinetics of T 47D human breast cancer cells

1989 ◽  
Vol 138 (3) ◽  
pp. 611-616 ◽  
Author(s):  
John A. Eisman ◽  
Robert L. Sutherland ◽  
M. Lynne McMenemy ◽  
Jean-Charles Fragonas ◽  
Elizabeth A. Musgrove ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cell Cycle Kinetics ◽  
Dihydroxyvitamin D3 ◽  
Kinetics Of

scholarly journals Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling

2008 ◽  
Vol 213 (2) ◽  
pp. 119-134 ◽  
Author(s):  
S.Y. Amy Cheung ◽  
Neil D. Evans ◽  
Michael J. Chappell ◽  
Keith R. Godfrey ◽  
Paul J. Smith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Compartmental Modelling

scholarly journals Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling

2018 ◽  
Vol 16 ◽  
pp. 1721727X1775180 ◽  
Author(s):  
Jin Mo Ku ◽  
Se Hyang Hong ◽  
Hyo In Kim ◽  
Ye Seul Lim ◽  
Sol Ji Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Akt Signaling ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
P53 Expression ◽  
Anti Cancer ◽  
Cucurbitacin D

Cucurbitacins are triterpenoids commonly found in Cucurbitaceae and Cruciferae and have long been used in traditional medicine. Cucurbitacins demonstrate anti-inflammatory and anti-cancer activities. We investigated whether cucurbitacin D affects viability in breast cancer cells and its mechanism of action. An MTT assay was used to measure the viability of breast cancer cells. Western blot analysis was used to measure the expression of various modulators, such as p-p53, p-Stat3, p-Akt, and p-NF-κB. Doxorubicin and cucurbitacin D affected the viability of MCF7, MDA-MB-231, and SKBR3 cells. Cucurbitacin D and doxorubicin increased p-p53 expression in MCF7, SKBR3, and MDA-MB-231 cells. Cucurbitacin D suppressed p-Akt, p-NF-κB, and p-Stat3 expression in MCF7, MDA-MB-231, and SKBR3 cells. Doxorubicin alone did not decrease p-Akt and p-Stat3 levels. Cucurbitacin D decreased p-NF-κB and p-Stat3 levels. Doxorubicin in combination with cucurbitacin D increased p-p53 levels and suppressed Akt, NF-κB, Stat3, and Bcl-2 expression more than cucurbitacin D alone. Our results clearly demonstrate that cucurbitacin D could be a useful compound for treating human breast cancer.

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