scholarly journals Rheumatoid Arthritis Synovial Inflammation Quantification Using Computer Vision

2022 ◽  
Author(s):  
Steven Guan ◽  
Bella Mehta ◽  
David Slater ◽  
James R. Thompson ◽  
Edward DiCarlo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Computer Vision ◽  
Synovial Inflammation

scholarly journals Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Zhongde Ye ◽  
Yi Shen ◽  
Ke Jin ◽  
Jingtao Qiu ◽  
Bin Hu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Arachidonic Acid ◽  
Lupus Erythematosus ◽  
Calcium Influx ◽  
Cell Receptor ◽  
Synovial Inflammation ◽  
Chimeric Mouse ◽  
T Cell Receptor Signaling ◽  
Chimeric Mouse Model

AbstractRheumatoid arthritis (RA) and psoriatic arthritis (PsA) are two distinct autoimmune diseases that manifest with chronic synovial inflammation. Here, we show that CD4+ T cells from patients with RA and PsA have increased expression of the pore-forming calcium channel component ORAI3, thereby increasing the activity of the arachidonic acid-regulated calcium-selective (ARC) channel and making T cells sensitive to arachidonic acid. A similar increase does not occur in T cells from patients with systemic lupus erythematosus. Increased ORAI3 transcription in RA and PsA T cells is caused by reduced IKAROS expression, a transcriptional repressor of the ORAI3 promoter. Stimulation of the ARC channel with arachidonic acid induces not only a calcium influx, but also the phosphorylation of components of the T cell receptor signaling cascade. In a human synovium chimeric mouse model, silencing ORAI3 expression in adoptively transferred T cells from patients with RA attenuates tissue inflammation, while adoptive transfer of T cells from healthy individuals with reduced expression of IKAROS induces synovitis. We propose that increased ARC activity due to reduced IKAROS expression makes T cells more responsive and contributes to chronic inflammation in RA and PsA.

scholarly journals NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Hui Liu ◽  
Yuanli Zhu ◽  
Yutong Gao ◽  
Dahu Qi ◽  
Liming Zhao ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Destruction ◽  
Synovial Inflammation

Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling

2013 ◽  
Vol 25 (10) ◽  
pp. 2069-2078 ◽  
Author(s):  
Cheng-gui Miao ◽  
Ying-ying Yang ◽  
Xu He ◽  
Xiao-feng Li ◽  
Cheng Huang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Wnt Signaling ◽  
Bone Remodeling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Synovial Inflammation

scholarly journals Leonurine attenuates fibroblast-like synoviocyte-mediated synovial inflammation and joint destruction in rheumatoid arthritis

Rheumatology ◽  
2017 ◽  
Vol 56 (8) ◽  
pp. 1417-1427 ◽  
Author(s):  
Nan Li ◽  
Qiang Xu ◽  
Qingping Liu ◽  
Dongmei Pan ◽  
Yubao Jiang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Joint Destruction ◽  
Synovial Inflammation
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