scholarly journals TNFi Cycling Versus Changing Mechanism of Action in TNFi‐Experienced Patients: Result of the Corrona CERTAIN Comparative Effectiveness Study

2021 ◽  
Author(s):  
Jeffrey R. Curtis ◽  
Joel M. Kremer ◽  
George Reed ◽  
Ani K. John ◽  
Dimitrios A. Pappas
Keyword(s):  
Mechanism Of Action ◽  
Comparative Effectiveness ◽  
Effectiveness Study ◽  
Comparative Effectiveness Study

scholarly journals Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: observational comparative effectiveness study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Helgo Magnussen ◽  
◽  
Sarah Lucas ◽  
Therese Lapperre ◽  
Jennifer K. Quint ◽  
...  
Keyword(s):  
Primary Care ◽  
Triple Therapy ◽  
Comparative Effectiveness ◽  
Inhaled Corticosteroids ◽  
Blood Eosinophil ◽  
Research Database ◽  
Effectiveness Study ◽  
Increased Risk ◽  
Comparative Effectiveness Study ◽  
Oral Corticosteroids

Abstract Background Inhaled corticosteroids (ICS) are indicated for prevention of exacerbations in patients with COPD, but they are frequently overprescribed. ICS withdrawal has been recommended by international guidelines in order to prevent side effects in patients in whom ICS are not indicated. Method Observational comparative effectiveness study aimed to evaluate the effect of ICS withdrawal versus continuation of triple therapy (TT) in COPD patients in primary care. Data were obtained from the Optimum Patient Care Research Database (OPCRD) in the UK. Results A total of 1046 patients who withdrew ICS were matched 1:4 by time on TT to 4184 patients who continued with TT. Up to 76.1% of the total population had 0 or 1 exacerbation the previous year. After controlling for confounders, patients who discontinued ICS did not have an increased risk of moderate or severe exacerbations (adjusted HR: 1.04, 95% confidence interval (CI) 0.94–1.15; p = 0.441). However, rates of exacerbations managed in primary care (incidence rate ratio (IRR) 1.33, 95% CI 1.10–1.60; p = 0.003) or in hospital (IRR 1.72, 95% CI 1.03–2.86; p = 0.036) were higher in the cessation group. Unsuccessful ICS withdrawal was significantly and independently associated with more frequent courses of oral corticosteroids the previous year and with a blood eosinophil count ≥ 300 cells/μL. Conclusions In this primary care population of patients with COPD, composed mostly of infrequent exacerbators, discontinuation of ICS from TT was not associated with an increased risk of exacerbation; however, the subgroup of patients with more frequent courses of oral corticosteroids and high blood eosinophil counts should not be withdrawn from ICS. Trial registration European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (EUPAS30851).

scholarly journals 4CPS-146 Ustekinumab and adalimumab for psoriasis patients who are no-responders to etanercept: a comparative effectiveness study

2018 ◽  
Author(s):  
S García Gil ◽  
F Gutiérrez Nicolás ◽  
GJ Nazco Casariego ◽  
M García Bustinduy ◽  
FJ Guimerá Martín-Neda ◽  
...  
Keyword(s):  
Comparative Effectiveness ◽  
Effectiveness Study ◽  
Comparative Effectiveness Study

scholarly journals A Cross-Site, Comparative Effectiveness Study of an Integrated HIV and Substance Use Treatment Program

2010 ◽  
Vol 24 (10) ◽  
pp. 651-658 ◽  
Author(s):  
Rae Jean Proeschold-Bell ◽  
Amy Heine ◽  
Brian Wells Pence ◽  
Keith McAdam ◽  
Evelyn Byrd Quinlivan
Keyword(s):  
Substance Use ◽  
Treatment Program ◽  
Comparative Effectiveness ◽  
Substance Use Treatment ◽  
Effectiveness Study ◽  
Comparative Effectiveness Study ◽  
Cross Site
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