scholarly journals Clinical Characteristics of Early‐Onset Gout in Outpatient Setting

2019 ◽  
Vol 1 (7) ◽  
pp. 397-402
Author(s):  
Yan Li ◽  
Paramarajan Piranavan ◽  
Devi Sundaresan ◽  
Robert Yood
Keyword(s):  
Early Onset ◽  
Clinical Characteristics ◽  
Outpatient Setting

scholarly journals Clinical Characteristics and Prognostic Factors of Early-Onset Pancreatic Neuroendocrine Tumors

2021 ◽  
Vol 28 ◽  
pp. 107327482098682
Author(s):  
Min Shi ◽  
Biao Zhou
Keyword(s):  
Prognostic Factors ◽  
Neuroendocrine Tumors ◽  
Early Onset ◽  
Older Patients ◽  
Clinical Characteristics ◽  
Clinicopathological Characteristics ◽  
Pancreatic Neuroendocrine Tumors ◽  
Chi Square ◽  
Younger Patients ◽  
Significant Difference

Background: The incidence of pancreatic neuroendocrine tumors (PNETs) has increased significantly. The purpose of this study was to analyze the clinical characteristics and prognosis of patients under 50 years old. Methods: Patients with PNETs recorded in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015 were analyzed. The clinical characteristics were analyzed by Chi-square test. The Kaplan-Meier method was used to estimate overall survival (OS). Multivariate Cox proportional risk regression analysis was used to determine independent prognostic factors. Results: 2,303 patients included, of which 547 (23.8%) patients were younger than 50 years old. The number of younger patients has increased steadily, while the proportion in total PNETs decreased recently. Compared with older group, the proportion of the Black, grade I/II, and surgery were higher in early-onset PNETs. Liver was the most frequent metastatic site. There was no significant difference in the incidence of different metastatic sites between younger and older PNETs patients, while younger patients had better OS (P < 0.05). Grade, N stage, M stage, and surgery were independent prognostic factors for OS in early-onset PNETs. Conclusions: Younger patients have unique clinicopathological characteristics compared with older patients in PNETs. Better OS was observed in younger patients which might due to the higher proportion of well-differentiated tumor and surgery than older patients.

Hyponatremia in the outpatient setting: clinical characteristics, risk factors, and outcome

2015 ◽  
Vol 47 (12) ◽  
pp. 1977-1983 ◽  
Author(s):  
Vildan Tasdemir ◽  
Ali Kemal Oguz ◽  
Irmak Sayın ◽  
Ihsan Ergun
Keyword(s):  
Risk Factors ◽  
Clinical Characteristics ◽  
Outpatient Setting

scholarly journals Comparison of clinical characteristics between familial and non-familial early onset Alzheimer’s disease

2012 ◽  
Vol 259 (10) ◽  
pp. 2182-2188 ◽  
Author(s):  
Aditi Joshi ◽  
John M. Ringman ◽  
Albert S. Lee ◽  
Kevin O. Juarez ◽  
Mario F. Mendez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Onset ◽  
Clinical Characteristics ◽  
Early Onset Alzheimer’S Disease

scholarly journals Early onset severe ATP1A2 epileptic encephalopathy: Clinical characteristics and underlying mutations

2021 ◽  
Vol 116 ◽  
pp. 107732
Author(s):  
Mary E. Moya-Mendez ◽  
David M. Mueller ◽  
Milton Pratt ◽  
Melanie Bonner ◽  
Courtney Elliott ◽  
...  
Keyword(s):  
Early Onset ◽  
Clinical Characteristics ◽  
Epileptic Encephalopathy

Clinical Characteristics of and Relationship Between Metabolic Components and Renal Function Among Patients with Early-onset Juvenile Tophaceous Gout

2014 ◽  
Vol 41 (9) ◽  
pp. 1878-1883 ◽  
Author(s):  
Chuan-Chin Lu ◽  
Shyi-Kuen Wu ◽  
Han-Yu Chen ◽  
Wei-Sheng Chung ◽  
Meng-Chih Lee ◽  
...  
Keyword(s):  
Renal Function ◽  
Early Onset ◽  
Clinical Characteristics ◽  
Middle Age ◽  
Age Of Onset ◽  
Relevant Information ◽  
Serum Urate ◽  
Common Site ◽  
Tophaceous Gout ◽  
Impaired Liver

Objective.Age of onset of gout has recently decreased; however, patients with early-onset gout remain uncommon, and relevant information is scant. We hypothesized that these patients might exhibit differences in serum urates and other comorbidities compared with adult-onset patients.Methods.Early-onset gout patients (i.e., juveniles) with (n = 40) and without tophi (n = 47) were enrolled for study. Their clinical characteristics were compared with those of 353 patients with middle-age-onset tophaceous gout and 64 age-matched healthy participants.Results.Early-onset gout patients with tophi exhibited significantly higher body mass indices and serum urate levels and lower estimated glomerular filtration rates (eGFR) than did those without tophi. Early-onset gout patients with or without tophi demonstrated significantly abnormal lipid profiles and impaired liver or renal function compared with healthy patients. Serum urate levels and gout duration were identified as the principal determinants of tophi development. The presence of tophi might be crucial in decreasing eGFR, which is inversely related to tophi duration or gout duration. Unexpectedly, the most common site of initial gout attacks in early-onset tophaceous gout patients was the ankle, not the toe, which was the most common site in middle-age-onset tophaceous gout patients. The most common site of first tophi occurrence in early-onset patients was a finger, not a toe, which was the most common site in middle-age-onset patients.Conclusion.Early-onset tophaceous gout patients are more likely to exhibit comorbidities and renal dysfunction than middle-age-onset patients and exhibit distinct first sites of gout attack and tophi occurrence patterns.

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