Is there an association of serum low density lipoprotein, high density lipoprotein or total cholesterol with development of knee osteoarthritis?

2020 ◽  
Author(s):  
Jessica L. Schwager ◽  
Michael C. Nevitt ◽  
James Torner ◽  
Cora E. Lewis ◽  
Nirupa R. Matthan ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density

scholarly journals Hubungan indeks massa tubuh dengan profil lipid pada pasien diabetes melitus tipe 2

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Pradika H. Koampa ◽  
Karel Pandelaki ◽  
Marthen C.P. Wongkar
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
Pearson Correlation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Diabetes Melitus

Abstract: Body Mass Index (BMI) is a measurement of nutritional status by calculating the ratio of height and weight. Type 2 Diabetes Mellitus (T2DM) is more common in a person with a BMI of more than normal. In patients with T2DM, there is lipid metabolism disorder, dyslipidaemia. Changes in lipid profiles consist of increased levels of total cholesterol, Low Density Lipoprotein (LDL), and triglycerides, and decreased levels of High Density Lipoprotein (HDL). This study aimed to obtain the correlation between body mass index and lipid profile in T2DM patients in Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study using patients’ medical record in Endocrine Clinic Prof. Dr. R. D. Kandou Hospital Manado from September to November 2015. The Pearson correlation test showed correlations between BMI and total cholesterol levels with r=0.037and p=0.763; between BMI and HDL levels with r=-0.249 and p=0.039; between BMI and LDL levels with r=0.091 and p=0,455; and between BMI and triglyceride levels with r=0.179 and p=0.142. Conclusion: Among T2DM patients, there were no significant correlations between body mass index and total cholesterol, LDL cholesterol, as wello as triglyceride levels. However, there was a significant correlation between body mass index and HDL levels. Keywords: body mass index, total cholesterol, HDL, LDL, triglycerides, T2DM Abstrak: Indeks Massa Tubuh (IMT) merupakan salah satu pengukuran status gizi dengan menghitung perbandingan tinggi badan dan berat badan. Diabetes Melitus Tipe 2 (DMT2) lebih sering terjadi pada individu dengan IMT lebih dari normal. Pada pasien DMT2 terjadi gangguan metabolisme lipid yaitu dislipidemia. Perubahan profil lipid yang terjadi yaitu peningkatan kadar Kolesterol Total, Low Density Lipoprotein (LDL), dan trigliserida, serta penurunan kadar High Density Lipoprotein (HDL). Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dengan profil lipid pada pasien DMT2di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif analitik dengan menggunakan data rekam medik pasien di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. Dr. R. D. Kandou Manado periode September – November 2015. Hasil uji korelasi Pearson memperlihatkan nilai hubungan antara IMT dan kadar kolesterol total r = 0,037 dan p = 0,763 ; nilai hubungan antara IMT dan kadar HDL r = -0,249 dan p = 0,039 ; nilai hubungan antara IMT dan kadar LDL r = 0,091 dan p = 0,455; serta nilai hubungan antara IMT dan kadar trigliserida r = 0,179 dan p = 0,142. Simpulan: Pada pasien DMT2 tidak dijumpai hubungan bermakna antara IMT dengan kadar kolesterol total, kadar LDL, dan kadar trigliserida, namun terdapat hubungan bermakna antara IMT dengan kadar HDL.Kata kunci: IMT, kolesterol total, HDL, LDL, trigliserida, DMT2

scholarly journals COMPARISON OF SDLDL-C ANALYSIS USING SRISAWASDI METHOD AND HOMOGENEOUS ENZYMATIC ASSAY METHOD ON HYPERTRIGLYCERIDEMIA CONDITION (Perbandingan Analisa sdLDL-C metode Srisawasdi dan Homogeneous Enzymatic Assay di Kondisi Hipertrigliseridemia)

2018 ◽  
Vol 23 (1) ◽  
pp. 74
Author(s):  
Gilang Nugraha ◽  
Soebagijo Poegoeh Edijanto ◽  
Edhi Rianto
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Enzymatic Assay ◽  
Assay Method ◽  
Low Density

Small Dense Low Density Lipoprotein (sdLDL) merupakan fraksi terkecil dari partikel Low Density Lipoprotein (LDL) yang memilikidiameter ≤25,5 nm. Partikel sdLDL merupakan lipoprotein sangat aterogenik bahkan telah dilaporkan meningkatkan kebahayaanPenyakit Jantung Koroner (PJK) hingga tiga kali lipat. Pengukuran sdLDL dilakukan dengan alat dan teknik yang rumit sehinggakurang cocok diterapkan dalam praktek klinis sehari-hari. Tahun 2011, Srisawasdi dkk mengembangkan teknik pengukuran perkiraansdLDL-cholesterol (sdLDL-C) menggunakan persamaan dengan menghitung profil lipid rutin. Dilaporkan bahwa peningkatan kepekatantrigliserida (TG) menurunkan kenasaban perkiraan sdLDL-C Srisawasdi. Penurunan nilai kenasaban dapat mempengaruhi ketepatanyang mengakibatkan penurunan mutu pemeriksaan laboratorium. Diambil 88 sampel yang dilakukan pengukuran Total Cholesterol(TC), TG, high density lipoprotein-cholesetrol (HDL-C) dan direk low density lipoprotein-cholesetrol (dLDL-C) di RSUD Dr. Soetomo,sdLDL-C metode homogeneous enzymatic assay dilakukan di Laboratorium Parahita Dharmawangsa. Hasil analisis menunjukkan, tidakada perbedaan hasil periksaan sdLDL-C formula Srisawasdi dkk dengan metode homogeneous enzymatic assay (P=0,000). Penurunannilai kenasaban ditemukan di kelompok kepekatan TG <100 mg/dL sampai dengan kelompok kepekatan TG 200-299 mg/dL. Perbedaannilai kenasaban di setiap kelompok TG tidak mempengaruhi ketepatan pemeriksaan sdLDL-C formula Srisawasdi (P=0,720) hinggakepekatan TG <400 mg/dL, dengan nilai bias pada seluruh sampel yaitu 34,15%. Keterbatasan sdLDL-C formula Srisawasdi dkk hanyadapat digunakan di kepekatan TG kurang dari 200 mg/dL dengan pemantapan mutu intralaboratorium yang terkendali baik. Saranpenelitian, perlu diteliti lebih lanjut untuk menentukan nilai normal sdLDL-C formula Srisawasdi.

The Effects of Low-Density Lipoprotein and High-Density Lipoprotein on Blood Viscosity Correlate with their Association with Risk of Atherosclerosis in Humans

1997 ◽  
Vol 92 (5) ◽  
pp. 473-479 ◽  
Author(s):  
Gregory D. Sloop ◽  
David W. Garber
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Blood Viscosity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

1. Increased blood or plasma viscosity has been observed in almost all conditions associated with accelerated atherosclerosis. Cognizant of the enlarging body of evidence implicating increased viscosity in atherogenesis, we hypothesize that the effects of low-density lipoprotein and high-density lipoprotein on blood viscosity correlate with their association with risk of atherosclerosis. 2. Blood viscometry was performed on samples from 28 healthy, non-fasting adult volunteers using a capillary viscometer. Data were correlated with haematocrit, fibrinogen, serum viscosity, total cholesterol, high-density lipoprotein-cholesterol, triglycerides and calculated low-density lipoprotein-cholesterol. 3. Low-density lipoprotein-cholesterol was more strongly correlated with blood viscosity than was total cholesterol (r = 0.4149, P = 0.0281, compared with r = 0.2790, P = 0.1505). High-density lipoprotein-cholesterol levels were inversely associated with blood viscosity (r = −0.4018, P = 0.0341). 4. To confirm these effects, viscometry was performed on erythrocytes, suspended in saline, which had been incubated in plasma of various low-density lipoprotein/high-density lipoprotein ratios. Viscosity correlated directly with low-density lipoprotein/high-density lipoprotein ratio (n = 23, r = 0.8561, P < 0.01). 5. Low-density lipoprotein receptor occupancy data suggests that these effects on viscosity are mediated by erythrocyte aggregation. 6. These results demonstrate that the effects of low-density lipoprotein and high-density lipoprotein on blood viscosity in healthy subjects correlate with their association with risk of atherosclerosis. These effects on viscosity may play a role in atherogenesis by modulating the dwell or residence time of atherogenic particles in the vicinity of the endothelium.

scholarly journals Alterations of pancreatic functions and lipid profiles in dairy cows with left displacement of the abomasum

2019 ◽  
Vol 64 (No. 5) ◽  
pp. 204-208
Author(s):  
Z Ismail ◽  
AM Al-Majali ◽  
O Al-Rawashdeh ◽  
M Daradka ◽  
M Mohaffel
Keyword(s):  
High Density Lipoprotein ◽  
Dairy Cows ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Reactive Protein

The objectives of this study were to determine the serum activities of the pancreatic enzymes amylase, lipase, trypsinogen 1 and trypsinogen 2, serum concentrations of total cholesterol, high density lipoprotein, low-density lipoprotein and triglycerides and serum inflammatory indicators, namely C-reactive protein and procalcitonin, in Holstein-Friesian dairy cows with left displacement of the abomasum (LDA). A total of 60 cows (30 LDA-affected and 30 healthy) were included in the study. Laboratory analyses were performed using commercially available ELISA kits and chemical reagents according to the manufacturers’ recommendations. There was a significant increase (P ≤ 0.05) in the activities of lipase, trypsinogen 1 and trypsinogen 2 in LDA-affected cows compared to healthy cows. Amylase concentrations, however, remained unchanged. The serum concentrations of total cholesterol and high-density lipoprotein were significantly (P ≤ 0.05) increased in LDA-affected cows while the concentrations of low-density lipoprotein and triglycerides were significantly (P ≤ 0.05) decreased compared to healthy cows. Procalcitonin and C-reactive protein concentrations were significantly (P ≤ 0.05) increased in LDA-affected cows compared to healthy cows. This study indicates that displacement of the abomasum may be associated with significant pathological effects in the pancreas that may affect cows in the post-operative period.

scholarly journals Uji Toksisitas Ekstrak Metanolik Kombinasi Daun Benalu Teh Dan Daun Benalu Mangga Terhadap Profil Lipid Tikus Betina (Rattus norvegicus) pada Paparan Sub-Kronik 28 Hari

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Tengku Anggun Lestari ◽  
Nour Athiroh ◽  
Nurul Jadid Mubarakati
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Rattus Norvegicus ◽  
Toxicity Test ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
One Way Anova

Tea Benalu (Scurrula atropurpurea [Bl.] Dans.) and Mango Benalu (Dendrophthoe pentandra L. miq.) containssecondary metabolites with potential antioxidant potential. Antioxidants can inhibit the oxidation process and reduce Total Cholesterol, Triglycerides, Low-Density Lipoprotein (LDL) and increase High-Density Lipoprotein (HDL). The safety of the preparations for the combination of parasites of tea and mango leaves was tested to obtain toxic effects after repeated treatment tests over some time. The purpose of this study was to determine the toxic effects of a combination of methanolic extracts of a combination of tea parasites and mangoes in female rats (Rattus norvegicus) subchronically for 28 days by looking at the results of the clinical biochemical examination on lipid profiles, namely total cholesterol levels, triglycerides, high-density lipoproteins (28%). HDL), and Low-Density Lipoprotein (LDL). The method of this study was experimental with a combination dose of methanol extract of tea parasite leaves and mango parasite leaves at a dose of 250 mg / KgBB, 500 mg / KgBB and 1000 mg / KgBB with 5x replications each treatment. The subjects used white rats (Rattus norvegicus) female Wistar strains aged 6-8 weeks with a minimum body weight of 100 grams. The treatment in this study was in the form of each dose given 5 times a week for 28 days (subchronic toxicity test) orally. Lipid profile levels were analyzed using the one-way ANOVA test. The results showed that the level of control blood lipid profile with a treatment dose of 250 mg / KgBW, 500 mg / KgBW, and 1000 mg / KgBW was not significantly different. The toxicity test of combined extracts of tea leaves and mango parasite leaves of female rat Rattus novergicus on subchronic exposure 28 days with those doses showed no difference tangible between treatments of controls. This means it is safe and does not cause toxic properties in the lipid profile of female wistar rats.Keywords: Lipid Profile, Scurrula atropurpurea, Dendophthoe pentandra, Sub-Chronic Toxicity, Rattus norvegicus ABSTRAKBenalu Teh (Scurrula atropurpurea [Bl.] Dans.) dan  Benalu Mangga (Dendrophthoe pentandra L. miq.) mengandung metabolit sekunder berpotensi sebagai antioksidan. Antioksidan dapat memperhambat proses oksidasi dan menurunkan Cholesterol Total, Trigliserida, Low Density Lipoprotein (LDL) dan menaikkan High Density Lipoprotein (HDL). Keamanan sediaan kombinasi daun benalu teh dan mangga diuji memperoleh tentang efek toksik setelah uji perlakuan berulang dalam jangka waktu tertentu. Tujuan dari penelitian ini untuk mengetahui efek toksik kombinasi ekstrak metanolik kombinasi daun benalu teh dan mangga pada tikus betina (Rattus norvegicus) secara subkronik selama 28 hari dengan melihat hasil pemeriksaan biokimia klinis pada profil lipid, yaitu kadar Cholesterol Total, Trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL). Metode penelitian ini adalah eksperimental dengan perlakuan dosis kombinasi ekstrak metanol daun benalu teh dan daun benalu mangga dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB dengan ulangan 5x tiap perlakuan. Subjek menggunakan tikus putih (Rattus norvegicus) betina strain wistar yang berumur 6-8 minggu dengan berat badan minimal 100 gram. Perlakuan dalam penelitian ini berupa setiap dosis  diberikan 5 kali seminggu selama 28 hari (uji toksisitas subkronik) secara per-oral. Kadar profil lipid dianalisis menggunakan uji One-way ANOVA. Hasil penelitian menunjukkan bahwa kadar profil lipid darah kontrol dengan perlakuan dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB tidak berbeda nyata. Uji”toksisitas”ekstrak kombinasi daun benalu teh dan daun benalu mangga  tikus betina Rattus novergicus pada paparan subkronik 28 hari dengan”dosis”tersebut menunjukkan hasil tidak”beda”nyata antara perlakuan terhadap”kontrol. ”Hal ini berarti aman dan tidak menimbulkan sifat toksik pada profil lipid tikus wistar betina.Kata Kunci : Profil Lipid, Scurrula atropurpurea, Dendophthoe pentandra, Subkronik, Rattus norvegicus

scholarly journals Effect of Unsaturated Fatty Acid Omega-3 on Some Biochemical Criteria in White New Zealand Rabbits Administrated with Cyclosporine Drug

2021 ◽  
Vol 2 (1) ◽  
pp. 15-24
Author(s):  
Murtadha M. Jawad
Keyword(s):  
Fatty Acid ◽  
Side Effects ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Unsaturated Fatty Acid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Omega 3

The present study was aimed efficiency to evaluate the unsaturated fatty acid omega-3 in reducing the side effects that resulted from the administration of cyclosporine drug in white rabbits. (60) white males' rabbits were used in this study, divided into four groups contain (15) rabbits per group and its subdivision into three groups (5) rabbits per group. The first group is orally administered with normal saline, the second group was administered cyclosporine (25mg/kg) only. Third groups were administered cyclosporine on the first day and omega-3 (500mg/kg) on the second day, while Fourth groups were administered cyclosporine on the first day and omega-3 (1000mg/kg) on the second day for periods (21,30,60) days respectively. After ending study periods, the animals were sacrificed and the blood was collected and the results were shown the following:  Administration with cyclosporine (25mg/kg)only and for periods were led to a significant increase(P<0.05) in total cholesterol, triglycerides and low-density lipoprotein(LDL) and a significant decrease(P<0.05) in high-density lipoprotein(HDL).whereas interaction with (500&1000mg/kg) of omega-3 and to all periods showed a significant decrease (p<0.05) in the total cholesterol, triglycerides and low-density lipoprotein(LDL) and significant decrease(p<0.05) in high-density lipoprotein(HDL), while the non-significant difference in high-density lipoprotein(HDL). This study concluded that omega-3 has an important role in reducing biochemistry side effects that result from the administration of cyclosporine drugs in white rabbits.

scholarly journals Evaluation of antiatherogenic effect of Alternanthera brasiliana Linn kuntz in rats on atherogenic diet

2019 ◽  
Vol 8 (6) ◽  
pp. 1172
Author(s):  
Urmi Choudhury ◽  
Tarali Devi ◽  
Asha Borah
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Methanolic Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Serum Total Cholesterol ◽  
Low Density ◽  
High Fat

Background: Hypercholesterolaemia is a major risk factor for systemic atherosclerosis and a well-known etiological factor for cardiovascular diseases and its complications which is a leading cause of mortality worldwide. In a recent study, the antihyperlipidemic activity of dried leaves extract of Alternanthera brasiliana has been evaluated. Hence, the present study was undertaken to investigate the anti-atherosclerotic potential of the methanolic extract of the leaves of Alternanthera brasiliana L. Kuntz (MEAB) in high fat diet induced hypercholesterolemic rat model.Methods: Thirty (30) wistar albino rats of either sex were randomly divided into five groups: first two groups received normal diet and high fat diet respectively and the remaining three groups received high fat diet supplemented with methanolic extract of Alternanthera brasiliana (MEAB) administered orally daily at two different doses: 200 mg/kg and 400 mg/kg and Atorvastatin 10 mg/kg/day orally as standard respectively. Serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) was estimated after 12 weeks. Atherogenic index was calculated from the results of lipid profile. At the end, the aorta was removed for assessment of atherosclerotic plagues.Results: Our results showed that MEAB possessed significant cholesterol lowering potency as indicated by decrease in serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) accompanied by an increase in serum high density lipoprotein (HDL-C) and reduces the atherosclerotic lesion of aorta (p <0.05).Conclusions: These results strongly suggests that MEAB can prevent the progress of atherosclerosis likely due to the effect of A. brasiliana on serum lipoproteins and its antioxidant and anti-inflammatory properties. It could be a potential therapy for the prevention and treatment of atherosclerosis.

scholarly journals Alterations of Lipid profile levels in 7,12-Dimethylbenz(a)anthracene induced ulcerative colitis rat model.

2017 ◽  
Vol 10 (4) ◽  
pp. 352
Author(s):  
Geetha Palaniswamy ◽  
Lakshman Kumar B ◽  
Indra U ◽  
Pavithra Sheetal B
Keyword(s):  
Ulcerative Colitis ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Intestinal Inflammation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Significant Difference

Objective: Ulcerative colitis is a type of inflammatory bowel disease is a chronic gastrointestinal disorder characterized by intestinal inflammation and mucosal tissue damage. We examined the lipid profile levels in murine model of 7,12 Dimethylbenz(a)anthracene induced ulcerative colitis.Methods: Serum was separated from whole blood and was used to determine the lipid profile such as total cholesterol (TC), phospholipids (PL), triglycerides (TG), free fatty acids, high density lipoprotein (HDL-C) and low density lipoprotein (HDL-C).Results: Ulcerative colitis rats exhibit low level of low density lipoprotein cholesterol and total cholesterol. No significant difference was observed in high density lipoprotein and triglycerides and significant difference was observed in phospholipids and free fatty acid serum levels. This communication highlights the lipid profile that occurs in ulcerative colitis.Conclusion: This study, thus, provides valuable information about the disturbances in the lipids and lipoproteins occur in ulcerative colitis.Keywords: Ulcerative colitis, 7,12-Dimethylbenz(a)anthracene, Lipoprotein, Low-density lipoprotein, Phospholipids.

scholarly journals Status of Lipid Profile among the Hypertensive Patients in Bangladesh

2014 ◽  
Vol 9 (1) ◽  
pp. 13-17 ◽  
Author(s):  
CM Reza ◽  
ASMA Kabir ◽  
Tuhin Biswas ◽  
Kamrun Nahar Choudhury ◽  
Md Zahidur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Hypertensive Patients

Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameter total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke. DOI: http://dx.doi.org/10.3329/uhj.v9i1.19505 University Heart Journal Vol. 9, No. 1, January 2013; 13-17

scholarly journals Hubungan Kadar Lipid Serum dengan Nilai Estimasi Laju Filtrasi Glomerulus pada Penyakit Ginjal Kronik

e-CliniC ◽  
2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Claudia E. Senge ◽  
Emma Sy. Moeis ◽  
Cerelia E.C. Sugeng
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Experimental Studies ◽  
Density Lipoprotein ◽  
High Density ◽  
Kidney Damage ◽  
Low Density ◽  
Number Of Patients ◽  
R Value

Abstract: Chronic kidney disease (CKD) is a health problem in the world and the number of patients continues to increase. The results of health research data base (Riskesdas) in 2013 suggested that the prevalence of CKD in Indonesia amounted to 0.2%. Riskesdas mentioned three provinces with the highest CKD cases in Indonesia, as follows: Central Sulawesi 0.5%, North Sulawesi 0.4%, and Gorontalo 0.4%. Dyslipidemia is characterized by the progressive increase in triglyceride rich lipoproteins (Tg), low density lipoprotein (LDL) and decreased high density lipoprotein (HDL), often associated with CKD and contributes to increased cardiovaskular risk. Various experimental studies also show that lipid abnormalities may aggravate the progression of kidney damage. Glomerular filtration rate (GFR) is one of the examination of kidney function in assessing the function of excretion that calculate the amount of filtrate which can be produced by the glomeruli. Decreased levels of LFG indicates the severity of kidney damage. This study was aimed to determine the relationship between serum lipid levels (total cholesterol, HDL, LDL, Tg) and eLFG in outpatients with CKD at Kidney-Hypertension Polyclinic of Prof Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study with a cross sectional retrospective design using data of the medical records of patients with CKD at Prof Dr. R. D. Kandou Hospital Manado. The study population was patients with CKD 4, CKD 5 ND, and CKD 5 HD. Samples were patients diagnosed as CKD outpatients at Kidney-Hypertension Polyclinic of Prof Dr. R. D. Kandou Hospital from July 2015 to July 2016. The relationships between the study variables were analyzed with Spearman-rho test. The relationships of the variables were as follows: total cholesterol and eLFG showed the r value of -0.279 (p= 0.039); HDL and eLFG showed the r value of -0.024 (p= 0.863); LDL and eLFG showed the r value of -0.287 (p = 0.034); triglycerides and eLFG showed the r value of 0.293 (p=0.039). Conclusion: There was a significant negative correlation between total cholesterol and LDL with eGFRCKD-EPI, and a significant positive correlation between triglyceride and eGFRCKD-EPI.Keywords: CKD, total cholesterol, HDL, LDL, Tg, eGFRCKD-EPI.Abstrak: Penyakit Ginjal Kronik (PGK) merupakan salah satu masalah kesehatan di dunia, dimana jumlah penderita terus meningkat. Hasil data riset kesehatan dasar (Riskesdas) tahun 2013 mengemukakan bahwa prevalensi PGK di Indonesia sebesar 0,2%. Riskesdas menyebutkan tiga provinsi dengan kasus PGK tertinggi di Indonesia adalah provinsi Sulawesi Tengah 0,5%, Sulawesi Utara 0,4% dan Gorontalo 0,4%. Displidemia ditandai oleh adanya peningkatan lipoprotein kaya trigliserida (Tg), Low Density Lipoprotein (LDL), dan penurunan High Density Lipoprotein (HDL), sering berhubungan dengan PGK dan berkontribusi pada peningkatan resiko kardiovaskular. Laju filtrasi glomerulus (LFG) merupakan salah satu pemeriksaan fungsi ginjal dalam menilai fungsi ekskresi, dengan cara menghitung banyaknya filtrat yang dapat dihasilkan oleh glomerulus. Derajat penurunan kadar LFG menandakan beratnya kerusakan ginjal. Penelitian ini bertuujuan untuk mengetahui hubungan kadar lipid serum (kolesterol total, HDL, LDL, Tg) dengan eLFG pada subyek PGK yang rawat jalan di Poliklinik Ginjal-Hipertensi RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang retrospektif menggunakan data rekam medis pasien PGK di RSUP Prof. Dr. R. D. Kandou Manado. Populasi penelitian ialah pasien PGK 4, PGK 5 ND dan PGK 5 HD. Sampel penelitian ialah pasien dengan diagnosis PGK yang rawat jalan di Poliklinik Ginjal – Hipertensi RSUP Prof. dr. R. D. Kandou Manado pada periode Juli 2015-Juli 2016. Hubungan antara variabel penelitian digunakan uji korelasi Spearmen-rho. Hasil penelitian hubungan kolesterol total dan eLFG mendapatkan nilai r= -0,279 dengan p= 0,039. Untuk hubungan HDL dan eLFG didapatkan nilai r= -0,024 dengan p= 0,863. Untuk hubungan LDL dan eLFG didapatkan nilai r= -0,287 dengan p= 0,034 dan untuk Tg dan eLFG didapatkan nilai r= 0,293. Simpulan: Terdapat hubungan korelasi negatif bermakna antara kolesterol total dan LDL dengan eLFGCKD-EPI serta hubungan korelasi positif bermakna antara trigliserida dengan eLFGCKD-EPI.Kata kunci: penyakit ginjal kronik, kolesterol total, HDL, LDL, Tg , eLFGCKD-EPI

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