Comparison of the Birmingham Vasculitis Activity Score and the Five‐Factor Score to Assess Survival in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A Study of 550 Patients From Spain (REVAS Registry)

2020 ◽  
Vol 72 (7) ◽  
pp. 1001-1010 ◽  
Author(s):  
Roser Solans‐Laqué ◽  
Monica Rodriguez‐Carballeira ◽  
Juan Jose Rios‐Blanco ◽  
Guadalupe Fraile ◽  
Luis Sáez‐Comet ◽  
...  
Keyword(s):  
Factor Score ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Activity Score ◽  
Birmingham Vasculitis Activity Score

Assessing the Performance of the Birmingham Vasculitis Activity Score at Diagnosis for Children with Antineutrophil Cytoplasmic Antibody-associated Vasculitis in A Registry for Childhood Vasculitis (ARChiVe)

2012 ◽  
Vol 39 (5) ◽  
pp. 1088-1094 ◽  
Author(s):  
KIMBERLY MORISHITA ◽  
SUZANNE C. LI ◽  
EYAL MUSCAL ◽  
STEVEN SPALDING ◽  
JAIME GUZMAN ◽  
...  
Keyword(s):  
Disease Activity ◽  
Assessment Tool ◽  
Rank Correlation ◽  
Treatment Decision ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Activity Score ◽  
Birmingham Vasculitis Activity Score ◽  
Spearman’S Rank Correlation ◽  
Spearman’S Rank Correlation Coefficient ◽  
Pediatric Vasculitis

Objective.There are no validated tools for measuring disease activity in pediatric vasculitis. The Birmingham Vasculitis Activity Score (BVAS) is a valid disease activity tool in adult vasculitis. Version 3 (BVAS v.3) correlates well with physician’s global assessment (PGA), treatment decision, and C-reactive protein in adults. The utility of BVAS v.3 in pediatric vasculitis is not known. We assessed the association of BVAS v.3 scores with PGA, treatment decision, and erythrocyte sedimentation rate (ESR) at diagnosis in pediatric antineutrophil cytoplasmic antibody-associated vasculitis (AAV).Methods.Children with AAV diagnosed between 2004 and 2010 at all ARChiVe centers were eligible. BVAS v.3 scores were calculated with a standardized online tool (www.vasculitis.org). Spearman’s rank correlation coefficient (rs) was used to test the strength of association between BVAS v.3 and PGA, treatment decision, and ESR.Results.A total of 152 patients were included. The physician diagnosis of these patients was predominantly granulomatosis with polyangiitis (n = 99). The median BVAS v.3 score was 18.0 (range 0–40). The BVAS v.3 correlations were rs = 0.379 (95% CI 0.233 to 0.509) with PGA, rs = 0.521 (95% CI 0.393 to 0.629) with treatment decision, and rs = 0.403 (95% CI 0.253 to 0.533) with ESR.Conclusion.Applied to children with AAV, BVAS v.3 had a weak correlation with PGA and moderate correlation with both ESR and treatment decision. Prospective evaluation of BVAS v.3 and/or pediatric-specific modifications to BVAS v.3 may be required before it can be formalized as a disease activity assessment tool in pediatric AAV.

Birmingham vasculitis activity score at diagnosis is a significant predictor of relapse of polyarteritis nodosa

2017 ◽  
Vol 37 (5) ◽  
pp. 685-694 ◽  
Author(s):  
Yoon-Jeong Oh ◽  
Sung Soo Ahn ◽  
Eun Seong Park ◽  
Seung Min Jung ◽  
Jason Jungsik Song ◽  
...  
Keyword(s):  
Polyarteritis Nodosa ◽  
Activity Score ◽  
Birmingham Vasculitis Activity Score

scholarly journals Assessment of the item selection and weighting in the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis

2008 ◽  
Vol 59 (6) ◽  
pp. 884-891 ◽  
Author(s):  
Alfred D. Mahr ◽  
Tuhina Neogi ◽  
Michael P. Lavalley ◽  
John C. Davis ◽  
Gary S. Hoffman ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Item Selection ◽  
Activity Score ◽  
Birmingham Vasculitis Activity Score

Microparticles Expressing Myeloperoxidase and Complement C3a and C5a as Markers of Renal Involvement in Antineutrophil Cytoplasmic Antibody–associated Vasculitis

2019 ◽  
Vol 47 (5) ◽  
pp. 714-721 ◽  
Author(s):  
Aleksandra Antovic ◽  
Fariborz Mobarrez ◽  
Milena Manojlovic ◽  
Nida Soutari ◽  
Victoria De Porta Baggemar ◽  
...  
Keyword(s):  
Disease Activity ◽  
Renal Involvement ◽  
Serum Levels ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Birmingham Vasculitis Activity Score ◽  
Complement Components ◽  
Anca Associated Vasculitis ◽  
Terminal Complement ◽  
Active Disease

Objective.To investigate expression of terminal complement components C3a and C5a on circulating myeloperoxidase (MPO)-positive microparticles (MPO+MP) in relation to disease activity and renal involvement in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).Methods.Forty-six clinically well-characterized patients with AAV and 23 age- and sex-matched healthy controls were included. The concentration of MPO+MP expressing C3a and C5a was analyzed from citrate plasma by flow cytometry. Serum levels of C3a and C5a were determined using commercial ELISA. The assessment of vasculitis disease activity was performed using the Birmingham Vasculitis Activity Score (BVAS). Among patients, 23 had active disease with BVAS ≥ 2 and 14 patients had active renal flares.Results.AAV patients had significantly increased expression of C3a and C5a on MPO+MP compared to controls (both p < 0.0001). When the group of patients with active AAV was divided according to the presence of renal activity, the concentration of MPO+MP expressing C3a and C5a was significantly higher in patients with renal involvement compared to patients with nonrenal disease and controls (p < 0.05 and p < 0.01, respectively). The serum levels of C3a were significantly decreased (p < 0.01) in the renal subgroup, while there were no changes in serum levels of C5a comparing the renal and nonrenal groups. There was significant correlation between the disease activity measured by BVAS and the levels of C3a and C5a expressed on MPO+MP.Conclusion.Determination of C3a and C5a on MPO+MP might be considered as a novel biomarker of renal involvement in patients with AAV and may be of importance in the pathogenetic process.

scholarly journals The prognostic significance of the Birmingham Vasculitis Activity Score (BVAS) with systemic vasculitis patients transferred to the intensive care unit (ICU)

Medicine ◽  
2016 ◽  
Vol 95 (48) ◽  
pp. e5506 ◽  
Author(s):  
Federico Biscetti ◽  
Angela Carbonella ◽  
Federico Parisi ◽  
Silvia Laura Bosello ◽  
Franco Schiavon ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Systemic Vasculitis ◽  
Prognostic Significance ◽  
Activity Score ◽  
Birmingham Vasculitis Activity Score
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