scholarly journals Novel Approach to Estimate Osteoarthritis Progression: Use of the Reliable Change Index in the Evaluation of Joint Space Loss

2019 ◽  
Vol 71 (2) ◽  
pp. 300-307 ◽  
Author(s):  
Camille M. Parsons ◽  
Andrew Judge ◽  
Kirsten Leyland ◽  
Olivier Bruyère ◽  
Florence Petit Dop ◽  
...  
Keyword(s):  
Joint Space ◽  
Reliable Change Index ◽  
Reliable Change ◽  
Novel Approach ◽  
Osteoarthritis Progression ◽  
Joint Space Loss

Die Wirksamkeit eines Frühinterventionsprogramms für Jugendliche mit Computerspiel- und Internetabhängigkeit: Mittelfristige Effekte der PROTECT+ Studie

2020 ◽  
Vol 48 (1) ◽  
pp. 3-14 ◽  
Author(s):  
Carolin Szász-Janocha ◽  
Eva Vonderlin ◽  
Katajun Lindenberg
Keyword(s):  
Internet Use ◽  
Health Problems ◽  
Reliable Change Index ◽  
Gaming Disorder ◽  
Statistical Classification ◽  
Reliable Change ◽  
Classification Of Diseases ◽  
International Statistical Classification

Zusammenfassung. Fragestellung: Das junge Störungsbild der Computerspiel- und Internetabhängigkeit hat in den vergangenen Jahren in der Forschung zunehmend an Aufmerksamkeit gewonnen. Durch die Aufnahme der „Gaming Disorder“ in die ICD-11 (International Statistical Classification of Diseases and Related Health Problems) wurde die Notwendigkeit von evidenzbasierten und wirksamen Interventionen avanciert. PROTECT+ ist ein kognitiv-verhaltenstherapeutisches Gruppentherapieprogramm für Jugendliche mit Symptomen der Computerspiel- und Internetabhängigkeit. Die vorliegende Studie zielt auf die Evaluation der mittelfristigen Effekte nach 4 Monaten ab. Methodik: N = 54 Patientinnen und Patienten im Alter von 9 bis 19 Jahren (M = 13.48; SD = 1.72) nahmen an der Frühinterventionsstudie zwischen April 2016 und Dezember 2017 in Heidelberg teil. Die Symptomschwere wurde zu Beginn, zum Abschluss der Gruppentherapie sowie nach 4 Monaten anhand von standardisierten Diagnostikinstrumenten erfasst. Ergebnisse: Mehrebenenanalysen zeigten eine signifikante Reduktion der Symptomschwere anhand der Computerspielabhängigkeitsskala (CSAS) nach 4 Monaten. Im Selbstbeurteilungsbogen zeigte sich ein kleiner Effekt (d = 0.35), im Elternurteil ein mittlerer Effekt (d = 0.77). Der Reliable Change Index, der anhand der Compulsive Internet Use Scale (CIUS) berechnet wurde, deutete auf eine starke Heterogenität im individuellen Symptomverlauf hin. Die Patientinnen und Patienten bewerteten das Programm zu beiden Follow-Up-Messzeitpunkten mit einer hohen Zufriedenheit. Schlussfolgerungen: Die vorliegende Arbeit stellt international eine der wenigen Studien dar, die eine Reduktion der Symptome von Computerspiel- und Internetabhängigkeit im Jugendalter über 4 Monate belegen konnte.

scholarly journals Phospholipase A2 inhibitor–loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression

2021 ◽  
Vol 7 (15) ◽  
pp. eabe6374
Author(s):  
Yulong Wei ◽  
Lesan Yan ◽  
Lijun Luo ◽  
Tao Gui ◽  
Biang Jang ◽  
...  
Keyword(s):  
Clinical Success ◽  
Joint Space ◽  
Therapeutic Agents ◽  
Knee Joints ◽  
Phospholipid Membrane ◽  
Drug Discovery And Development ◽  
Knee Oa ◽  
Clinical Challenge ◽  
Osteoarthritis Progression ◽  
Human And Mouse

Treating osteoarthritis (OA) remains a major clinical challenge. Despite recent advances in drug discovery and development, no disease-modifying drug for knee OA has emerged with any notable clinical success, in part, due to the lack of valid and responsive therapeutic targets and poor drug delivery within knee joints. In this work, we show that the amount of secretory phospholipase A2 (sPLA2) enzyme increases in the articular cartilage in human and mouse OA cartilage tissues. We hypothesize that the inhibition of sPLA2 activity may be an effective treatment strategy for OA. To develop an sPLA2-responsive and nanoparticle (NP)–based interventional platform for OA management, we incorporated an sPLA2 inhibitor (sPLA2i) into the phospholipid membrane of micelles. The engineered sPLA2i-loaded micellar NPs (sPLA2i-NPs) were able to penetrate deep into the cartilage matrix, prolong retention in the joint space, and mitigate OA progression. These findings suggest that sPLA2i-NPs can be promising therapeutic agents for OA treatment.

scholarly journals Joint Space Loss after Arthroscopic Partial Meniscectomy: Data from the Osteoarthritis Initiative

2013 ◽  
Vol 1 (4_suppl) ◽  
pp. 2325967113S0003
Author(s):  
Alexander Rothy ◽  
Steven Cherney ◽  
Stephen D. Fening ◽  
Jeffrey Duryea ◽  
Carl S. Winalski ◽  
...  
Keyword(s):  
Joint Space ◽  
Partial Meniscectomy ◽  
Arthroscopic Partial Meniscectomy ◽  
Osteoarthritis Initiative ◽  
Joint Space Loss

scholarly journals Validating the Reliable Change Index with Tensor-Based Morphometry: the ADNI-MEM and the ADNI-EF

2019 ◽  
Vol 34 (6) ◽  
pp. 847-847
Author(s):  
S Lin ◽  
E Fletcher ◽  
B Gavett
Keyword(s):  
Neuropsychological Test ◽  
Regional Analysis ◽  
Brain Regions ◽  
Reliable Change Index ◽  
Cognitive Test ◽  
Parahippocampal Gyrus ◽  
Reliable Change ◽  
Confounding Variables ◽  
One Year ◽  
Neuroanatomical Data

Abstract Objective The Reliable Change Index (RCI) is a commonly used method for interpreting change in neuropsychological test scores over time. However, the RCI is a psychometric phenomenon that, to date, has not been validated by neuroanatomical evidence. Method Longitudinal neuroimaging and neuropsychological data from baseline and one-year follow-up visits were retrieved from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. The RCI was used to identify participants showing reliable decline on ADNI-MEM and ADNI-EF factor scores, which provide composite measures of memory and executive functioning, respectively. For each cognitive test score, two groups (reliable change vs. no reliable change) were matched on potential confounding variables using a genetic algorithm. Longitudinal neuroanatomical data were analyzed using tensor-based morphometry. Results Whole brain analysis revealed that reliable change on ADNI-MEM was associated with extended atrophy of the temporal lobe, the parahippocampal gyrus, the entorhinal cortex, and the posterior cingulate gyrus (Left Figure). Similar extended atrophy patterns were found for reliable change on ADNI-EF, except that the atrophy was more extensive and of higher magnitude (Right Figure). Regional analysis further confirmed that in such brain regions, the reliable change group manifested higher grey matter loss than the no change group. Conclusion The current study not only validated clinical usage of the RCI with neuroanatomical evidence but also practically suggested patterns of likely brain atrophy when reliable cognitive decline is detected.

Arthrographic Study of the Communication between the Tarsal Joints in Crioulo Horses

2019 ◽  
Vol 32 (04) ◽  
pp. 269-273
Author(s):  
Marcelo V. Gehm ◽  
Claudia A. Duarte ◽  
Carla T. Leite ◽  
Geórgia C. Góss ◽  
Gabriela Döwich ◽  
...  
Keyword(s):  
Data Collection ◽  
Clinical Significance ◽  
Positive Contrast ◽  
Joint Space ◽  
Radiographic Images ◽  
Tarsometatarsal Joint ◽  
Chi Squared ◽  
Therapeutic Procedures ◽  
Intertarsal Joint ◽  
Joint Space Loss

Abstract Objective The aim of the present study is to assess an arthrographic technique based on the access to the equine tarsus via distal intertarsal and on the existence and frequency of communication between distal and tarsocrural joints in the tarsus of Crioulo horses. Materials and Methods Fifty Crioulo horses of both sexes from 3 to 8 years old were included in the experiment. Animals with radiographic signs of tarsal osteoarthritis and joint space loss were excluded from the experiment. Contrast was injected in the distal intertarsal joint and radiographs were taken at two different times - Time 0 (after contrast application) and Time 1 (45 seconds after) to detect any communication between tarsal joints. The recorded results were analysed through chi-squared test. Results Thirty out of three hundred tarsi were excluded from the experiment since the radiographic images showed loss of the distal intertarsal joint space. Positive contrast was injected in distal intertarsal joint of 70/100 tarsi. There was not any contrast overflow in the 30/70 assessed tarsi. Contrast diffused to the tarsometatarsal joint in 32/70 of the assessed tarsi and reached tarsocrural joints in 8/70 tarsi. The adopted arthrographic technique was effective in data collection and evaluation; however, 52/70 of tarsi showed contrast overflow to the bursa of the cunean tendon. Clinical significance The communication between tarsocrural and distal tarsal joints in Crioulo horses was significantly higher, and this finding emphasizes the importance of performing contrasted arthrography before getting to a final diagnostic and defining therapeutic procedures.

Experimental and Novel Analytical Trajectory Optimization of a 7-DOF Baxter Robot: Global Design Sensitivity and Step Size Analyses

2017 ◽  
Author(s):  
Mostafa Bagheri ◽  
Peiman Naseradinmousavi ◽  
Rasha Morsi
Keyword(s):  
Global Optimization ◽  
Cost Function ◽  
Trajectory Optimization ◽  
Computational Cost ◽  
Joint Space ◽  
Design Sensitivity ◽  
Target Object ◽  
Size Analysis ◽  
Step Size ◽  
Novel Approach

In this paper, we present a novel nonlinear analytical coupled trajectory optimization of a 7-DOF Baxter manipulator validated through experimental work utilizing global optimization tools. The robotic manipulators used in network-based applications of industrial units and even homes, for disabled patients, spend significant lumped amount of energy and therefore, optimal trajectories need to be generated to address efficiency issues. We here examine both heuristic (Genetics) and gradient based (GlobalSearch) algorithms for a novel approach of “S-Shaped” trajectory (unlike conventional polynomials), to avoid being trapped in several possible local minima along with yielding minimal computational cost, enforcing operational time and torque saturation constraints. The global schemes are utilized in minimizing the lumped amount of energy consumed in a nominal path given in the collision-free joint space except an impact between the robot’s end effector and a target object for the nominal operation. Note that such robots are typically operated for thousands of cycles resulting in a considerable cost of operation. Due to the expected computational cost of such global optimization algorithms, step size analysis is carried out to minimize both the computational cost (iteration) and possibly cost function by finding an optimal step size. Global design sensitivity analysis is also performed to examine the effects of changes of optimization variables on the cost function defined.

scholarly journals The Development of a Reliable Change Index and Cutoff for the Revised Dyadic Adjustment Scale

2014 ◽  
Vol 40 (4) ◽  
pp. 525-534 ◽  
Author(s):  
Shayne R. Anderson ◽  
Rachel B. Tambling ◽  
Scott C. Huff ◽  
Joy Heafner ◽  
Lee N. Johnson ◽  
...  
Keyword(s):  
Dyadic Adjustment ◽  
Reliable Change Index ◽  
Reliable Change ◽  
Dyadic Adjustment Scale
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