scholarly journals Is Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis Still a More Severe Disease Than Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis? A Longitudinal Cohort Study in Rheumatoid Arthritis Patients Diagnosed From 2000 Onwar

2018 ◽  
Vol 70 (7) ◽  
pp. 987-996 ◽  
Author(s):  
Aleid C. Boer ◽  
Annelies Boonen ◽  
Annette H. M. van der Helm van Mil
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Severe Disease ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Citrullinated Protein

scholarly journals Risk of mortality in patients with psoriatic arthritis, rheumatoid arthritis and psoriasis: a longitudinal cohort study

2012 ◽  
Vol 73 (1) ◽  
pp. 149-153 ◽  
Author(s):  
Alexis Ogdie ◽  
Kevin Haynes ◽  
Andrea B Troxel ◽  
Thorvardur Jon Love ◽  
Sean Hennessy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Psoriatic Arthritis ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Risk Of Mortality ◽  
Arthritis Rheumatoid

Relationship between disease activity of rheumatoid arthritis and development of locomotive syndrome: A five-year longitudinal cohort study

2020 ◽  
Vol 31 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Yasumori Sobue ◽  
Toshihisa Kojima ◽  
Koji Funahashi ◽  
Nobuyuki Okui ◽  
Nobunori Takahashi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Disease Activity ◽  
Longitudinal Cohort Study ◽  
Locomotive Syndrome ◽  
Longitudinal Cohort

The Incidence of Upper Extremity Surgery for Rheumatoid Arthritis: A National, Population-Based Longitudinal Cohort Study

2014 ◽  
Vol 39 (9) ◽  
pp. e24
Author(s):  
Jennifer F. Waljee ◽  
Lin Zhong ◽  
Hyungjin M. Kim ◽  
Onur Baser ◽  
David A. Fox ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Upper Extremity ◽  
Population Based ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
National Population

scholarly journals BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Fiona Rayner ◽  
Amy E. Anderson ◽  
Kenneth F. Baker ◽  
Christopher D. Buckley ◽  
Bernard Dyke ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Immune Cell ◽  
Previous Treatment ◽  
Synovial Biopsy ◽  
Longitudinal Cohort Study ◽  
Sustained Remission ◽  
Ultrasound Guided ◽  
Multivariate Statistical ◽  
Longitudinal Cohort

Abstract Background Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flares), converting diseases from inactive to active states. Focussing on rheumatoid arthritis (RA), the challenge that we will address is why IMIDs remit and relapse. Extrapolating from pathogenetic factors involved in disease initiation, new episodes of inflammation could be triggered by recurrent systemic immune dysregulation or locally by factors within the joint, either of which could be endorsed by overarching epigenetic factors or changes in systemic or localised metabolism. Methods The BIO-FLARE study is a non-randomised longitudinal cohort study that aims to enrol 150 patients with RA in remission on a stable dose of non-biologic disease-modifying anti-rheumatic drugs (DMARDs), who consent to discontinue treatment. Participants stop their DMARDs at time 0 and are offered an optional ultrasound-guided synovial biopsy. They are studied intensively, with blood sampling and clinical evaluation at weeks 0, 2, 5, 8, 12 and 24. It is anticipated that 50% of participants will have a disease flare, whilst 50% remain in drug-free remission for the study duration (24 weeks). Flaring participants undergo an ultrasound-guided synovial biopsy before reinstatement of previous treatment. Blood samples will be used to investigate immune cell subsets, their activation status and their cytokine profile, autoantibody profiles and epigenetic profiles. Synovial biopsies will be examined to profile cell lineages and subtypes present at flare. Blood, urine and synovium will be examined to determine metabolic profiles. Taking into account all generated data, multivariate statistical techniques will be employed to develop a model to predict impending flare in RA, highlighting therapeutic pathways and informative biomarkers. Despite initial recruitment to time and target, the SARS-CoV-2 pandemic has impacted significantly, and a decision was taken to close recruitment at 118 participants with complete data. Discussion This study aims to investigate the pathogenesis of flare in rheumatoid arthritis, which is a significant knowledge gap in our understanding, addressing a major unmet patient need. Trial registration The study was retrospectively registered on 27/06/2019 in the ISRCTN registry 16371380.

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