scholarly journals Features of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study

2016 ◽  
Vol 68 (11) ◽  
pp. 1736-1741 ◽  
Author(s):  
Roberta C. Gomes ◽  
Marco F. Silva ◽  
Katia Kozu ◽  
Eloisa Bonfá ◽  
Rosa M. Pereira ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Multicenter Study ◽  
Lupus Erythematosus ◽  
Age Groups ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Characterization of chronic arthritis in a multicenter study of 852 childhood-onset systemic lupus erythematosus patients

2016 ◽  
Vol 36 (12) ◽  
pp. 1641-1648 ◽  
Author(s):  
Ana Paula Sakamoto ◽  
Clovis Artur Silva ◽  
Mariana Paes Leme Ferriani ◽  
Rosa Maria Rodrigues Pereira ◽  
Eloisa Bonfá ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Multicenter Study ◽  
Lupus Erythematosus ◽  
Chronic Arthritis ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Evans Syndrome at Childhood-Onset Systemic Lupus Erythematosus Diagnosis: A Large Multicenter Study

2016 ◽  
Vol 63 (7) ◽  
pp. 1238-1243 ◽  
Author(s):  
Gabriella E. Lube ◽  
Mariana Paes Leme Ferriani ◽  
Lucia Maria Arruda Campos ◽  
Maria Teresa Terreri ◽  
Eloisa Bonfá ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Multicenter Study ◽  
Lupus Erythematosus ◽  
Evans Syndrome ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Systemic Lupus Erythematosus Diagnosis ◽  
Large Multicenter Study ◽  
Onset Systemic Lupus Erythematosus

Childhood-onset systemic lupus erythematosus-related antiphospholipid syndrome: A multicenter study with 1519 patients

2020 ◽  
Vol 19 (12) ◽  
pp. 102693
Author(s):  
Aline G. Islabão ◽  
Licia M.H. Mota ◽  
Maria Custodia M. Ribeiro ◽  
Tamima M. Arabi ◽  
Georgiana N. Cividatti ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Antiphospholipid Syndrome ◽  
Multicenter Study ◽  
Lupus Erythematosus ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Characteristics of 1555 childhood-onset lupus in three groups based on distinct time intervals to disease diagnosis: a Brazilian multicenter study

Lupus ◽  
2018 ◽  
Vol 27 (10) ◽  
pp. 1712-1717 ◽  
Author(s):  
G V Novak ◽  
B C Molinari ◽  
J C Ferreira ◽  
A P Sakamoto ◽  
MT Terreri ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Multicenter Study ◽  
Lupus Erythematosus ◽  
Disease Diagnosis ◽  
Time Interval ◽  
Short Time Interval ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Group A ◽  
Onset Systemic Lupus Erythematosus

Objective The objective of this study was to compare demographic data, clinical/laboratorial features and disease activity at diagnosis in three different groups with distinct time intervals between onset of signs/symptoms and disease diagnosis. Methods A multicenter study was performed in 1555 childhood-onset systemic lupus erythematosus (American College of Rheumatology criteria) patients from 27 pediatric rheumatology services. Patients were divided into three childhood-onset systemic lupus erythematosus groups: A: short time interval to diagnosis (<1 month); B: intermediate time interval (≥1 and <3 months); and C: long time interval (≥3 months). An investigator meeting was held to define the protocol. Demographic data, SLICC classification criteria and SLEDAI-2 K were evaluated. Results The number of patients in each group was: A = 60 (4%); B = 522 (33.5%); and C = 973 (62.5%). The median age at diagnosis (11.1 (4.2–17) vs. 12 (1.9–17.7) vs. 12.5 (3–18) years, P = 0.025) was significantly lower in group A compared with groups B and C. The median number of diagnostic criteria according to SLICC (7 (4–12) vs. 6 (4–13) vs. 6 (4–12), P < 0.0001) and SLEDAI-2 K (18 (6–57) vs. 16 (2–63) vs. 13 (1–49), P < 0.0001) were significantly higher in group A than the other two groups. The frequency of oral ulcers in the palate (25% vs. 15% vs. 11%, P = 0.003), pleuritis (25% vs. 24% vs. 14%, P < 0.0001), nephritis (52% vs. 47% vs. 40%, P = 0.009), neuropsychiatric manifestations (22% vs. 13% vs. 10%, P = 0.008), thrombocytopenia (32% vs. 18% vs. 19%, P = 0.037), leucopenia/lymphopenia (65% vs. 46% vs. 40%, P < 0.0001) and anti-dsDNA antibodies (79% vs. 66% vs. 61%, P = 0.01) were significantly higher in group A compared with the other groups. In contrast, group C had a less severe disease characterized by higher frequencies of synovitis (61% vs. 66% vs. 71%, P = 0.032) and lower frequencies of serositis (37% vs. 33% vs. 25%, P = 0.002), proteinuria >500 mg/day (48% vs. 45% vs. 36%, P = 0.002) and low complement levels (81% vs. 81% vs. 71%, P < 0.0001) compared with groups A or B. Conclusions Our large Brazilian multicenter study demonstrated that for most childhood-onset systemic lupus erythematosus patients, diagnosis is delayed probably due to mild disease onset. Conversely, the minority has a very short time interval to diagnosis and a presentation with a more severe and active multisystemic condition.

Initial presentation of childhood-onset systemic lupus erythematosus: A French multicenter study

2005 ◽  
Vol 146 (5) ◽  
pp. 648-653 ◽  
Author(s):  
B. Bader-Meunier ◽  
J.B. Armengaud ◽  
E. Haddad ◽  
R. Salomon ◽  
G. Deschênes ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Multicenter Study ◽  
Lupus Erythematosus ◽  
Initial Presentation ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Herpes zoster infection in childhood-onset systemic lupus erythematosus patients: a large multicenter study

Lupus ◽  
2016 ◽  
Vol 25 (7) ◽  
pp. 754-759 ◽  
Author(s):  
J C O A Ferreira ◽  
H H Marques ◽  
M P L Ferriani ◽  
N W S Gormezano ◽  
M T Terreri ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Herpes Zoster ◽  
Multicenter Study ◽  
Lupus Erythematosus ◽  
Herpes Zoster Infection ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Large Multicenter Study ◽  
Onset Systemic Lupus Erythematosus
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