scholarly journals 25-Hydroxyvitamin D and Cardiovascular Disease in Patients With Systemic Lupus Erythematosus: Data From a Large International Inception Cohort

2014 ◽  
Vol 66 (8) ◽  
pp. 1167-1176 ◽  
Author(s):  
Apinya Lertratanakul ◽  
Peggy Wu ◽  
Alan Dyer ◽  
Murray Urowitz ◽  
Dafna Gladman ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Lupus Erythematosus ◽  
Inception Cohort ◽  
Systemic Lupus ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

The predictive factors of low serum 25-hydroxyvitamin D and vitamin D deficiency in patients with systemic lupus erythematosus

2012 ◽  
Vol 33 (6) ◽  
pp. 1461-1467 ◽  
Author(s):  
Kittiwan Sumethkul ◽  
Smonporn Boonyaratavej ◽  
Tasanee Kitumnuaypong ◽  
Sungchai Angthararuk ◽  
Patcharin Cheewasat ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Predictive Factors ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Low Serum

scholarly journals 25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus

2009 ◽  
Vol 61 (10) ◽  
pp. 1387-1395 ◽  
Author(s):  
Peggy W. Wu ◽  
Elisa Y. Rhew ◽  
Alan R. Dyer ◽  
Dorothy D. Dunlop ◽  
Craig B. Langman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals The role of vitamin D3 deficiency correction in optimizing the treatment of anemia in women with autoimmune diseases

2021 ◽  
pp. 7-10
Author(s):  
Iu.V. Davydova ◽  
◽  
A.Y. Lymanskaya ◽  
O.M. Kravets ◽  
◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Lupus Erythematosus ◽  
Ferrous Sulfate ◽  
Serum Iron ◽  
Systemic Lupus ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

The aim is to analyze the effectiveness of correction vitamin D deficiency in the treatment of anemia in women with systemic lupus erythematosus (SLE). Materials and methods. Concomitant documented levels of 25-hydroxyvitamin D, hemoglobin, ferritin, and serum iron in a group of women with SLE who applied for preconception counseling were analyzed. All women were in remission for SLE activity within 5 to 6 months. A total of 54 women were involved in iron metabolism disorders (decreased ferritin, hemoglobin, serum iron). Vitamin D deficiency was detected at <30 ng/ml, and anemia at hemoglobin <120 g/l. Group 1 consisted of 32 women with vitamin D levels <30 ng/ml who received antianemic therapy with ferrous sulfate with ascorbic acid, correction of vitamin D deficiency with Olidetrim 2000 U (Polpharma), and group 2 — women with vitamin D levels <30 ng/ml (n=22) who received antianemic therapy with ferrous sulfate with ascorbic acid and a vitamin complex containing vitamin D 400 U. The groups were comparable by the main demographic indicators (age, education, socio-economic level). In both groups, iron metabolism and 25-hydroxyvitamin D levels were monitored in 4 weeks after treatment. Results and conclusions. Women with SLE have a high risk of chronic inflammatory anemia development, which can be combined with iron deficiency anemia. To improve the results of treatment, it is proposed to introduce supplementation with a high dose of vitamin D (Olidetrim 2000 U), into complex therapy which contributes to the effectiveness of correction of deficiency of this vitamin, as well as the onset of long-term recovery of iron store, hemoglobin concentration. The study was conducted in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of women was obtained for the research. The authors declare no conflict of interest. Key words: vitamin D deficiency, pregnant women, systemic lupus erythematosus, supplementation.

scholarly journals An evaluation of vitamin D status in individuals with systemic lupus erythematosus

2011 ◽  
Vol 70 (4) ◽  
pp. 399-407 ◽  
Author(s):  
Leanne C. Breslin ◽  
Pamela J. Magee ◽  
Julie M. W. Wallace ◽  
Emeir M. McSorley
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Additional Stress ◽  
Vitamin D Status ◽  
Systemic Lupus ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
25 Hydroxyvitamin D

Systemic lupus erythematosus (SLE) is a multi-system inflammatory disease where genetic susceptibility coupled with largely undefined environmental factors is reported to underlie the aetiology of the disease. One such factor is low vitamin D status. The primary source of vitamin D is endogenous synthesis following exposure of the skin to UVB light. Photosensitivity, sunlight avoidance and the use of sun protection factor in combination with medications prescribed to treat the symptoms of the disease, puts SLE patients at increased risk of vitamin D deficiency. Decreased conversion of 25-hydroxyvitamin D to the metabolically active form, 1,25-dihydroxyvitamin D3, is possible, due to renal impairment common in SLE putting additional stress on vitamin D metabolism. The majority of studies have identified low 25-hydroxyvitamin D in SLE patients, albeit using varying cut-offs (<25 to <80 nmol/l). Of these studies, fifteen have investigated a link between status and disease activity with conflicting results. Variation with disease activity index measures used alongside methodological limitations within the study design may partially explain these findings. This review discusses the importance of optimal vitamin D status in SLE, critically evaluates research carried out to date that has investigated vitamin D in SLE, and highlights the need for a well-designed observational study that controls for diet, medication use, dietary supplements, UV exposure and seasonality, that uses sensitive methods for measuring vitamin D status and disease activity in SLE to conclusively establish the role of vitamin D in SLE.

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