scholarly journals Association of Circulating Level of High Mobility Group Box 1 With Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis

2013 ◽  
Vol 65 (11) ◽  
pp. 1828-1834 ◽  
Author(s):  
Chen Wang ◽  
Shen-Ju Gou ◽  
Dong-Yuan Chang ◽  
Feng Yu ◽  
Ming-Hui Zhao ◽  
...  
Keyword(s):  
Disease Activity ◽  
High Mobility ◽  
High Mobility Group ◽  
Antineutrophil Cytoplasmic Autoantibody

scholarly journals Urinary Levels of High Mobility Group Box-1 Are Associated with Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0123586 ◽  
Author(s):  
Tian-Tian Ma ◽  
Huan Wang ◽  
Chen Wang ◽  
Dong-Yuan Chang ◽  
Ming-Hui Zhao ◽  
...  
Keyword(s):  
Disease Activity ◽  
High Mobility ◽  
High Mobility Group ◽  
Antineutrophil Cytoplasmic Autoantibody ◽  
Urinary Levels

Expression of High Mobility Group Box Chromosomal Protein 1 and Its Modulating Effects on Downstream Cytokines in Systemic Lupus Erythematosus

2010 ◽  
Vol 37 (4) ◽  
pp. 766-775 ◽  
Author(s):  
JIE LI ◽  
HONGFU XIE ◽  
TING WEN ◽  
HONGBO LIU ◽  
WU ZHU ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Messenger Rna ◽  
Activity Index ◽  
High Mobility ◽  
High Mobility Group ◽  
Chromosomal Protein ◽  
Systemic Lupus ◽  
Tnf Α

Objective.To compare the expression of high mobility group box chromosomal protein 1 (HMGB1) and the modulating effects on its downstream cytokines in patients with systemic lupus erythematosus (SLE) and healthy controls.Methods.HMGB1 concentrations in serum from SLE patients and controls were measured by immunoblot analysis. HMGB1 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMC) was detected by real-time reverse transcription–polymerase chain reaction. Immunofluorescence assay was employed to examine the translocation of HMGB1 in monocytes after endotoxin stimulation. Release of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) by PBMC after rHMGB1 stimulation was also measured.Results.Serum HMGB1 levels and HMGB1 mRNA expressions in PBMC were elevated in SLE patients compared with controls. A positive correlation was demonstrated between HMGB1 concentrations and SLE Disease Activity Index. There was an inverse correlation between HMGB1 levels and C4 and C3 concentrations in SLE patients. HMGB1 concentrations were higher in patients with vasculitis and myositis. Lipopolysaccharide stimulated a temporarily elevated release of HMGB1 in SLE patients compared with controls. The pattern and localization of HMGB1 staining in monocytes were similar in both groups. After stimulation with rHMGB1, TNF-α level decreased but IL-6 level increased in SLE patients compared with controls.Conclusion.Our findings suggest that increased serum levels of HMGB1 in SLE may be associated with lupus disease activity. The altered production of TNF-α and IL-6 in response to rHMGB1 stimulation may participate in the disruption of cytokine homeostasis in SLE.

scholarly journals High mobility group box 1 serum levels are increased in Behçet’s disease, but not associated with disease activity or disease manifestations

Rheumatology ◽  
2015 ◽  
pp. kev202 ◽  
Author(s):  
Alexandre W. S. de Souza ◽  
Sandro Félix Perazzio ◽  
Natália Regine de França ◽  
Luis Eduardo C. Andrade ◽  
Marc Bijl ◽  
...  
Keyword(s):  
Disease Activity ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
High Mobility ◽  
Serum Levels ◽  
High Mobility Group ◽  
Behcet's Disease

scholarly journals High mobility group box 1 levels in large vessel vasculitis are not associated with disease activity but are influenced by age and statins

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Alexandre W. S. de Souza ◽  
Kornelis S. M. van der Geest ◽  
Elisabeth Brouwer ◽  
Frederico A. G. Pinheiro ◽  
Ana Cecília Diniz Oliveira ◽  
...  
Keyword(s):  
Disease Activity ◽  
High Mobility ◽  
Large Vessel Vasculitis ◽  
Large Vessel ◽  
High Mobility Group
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