scholarly journals A Case of Progressive Quadriceps Weakness and Elevated Creatine Kinase Level Mimicking Inclusion Body Myositis

2014 ◽  
Vol 66 (2) ◽  
pp. 328-333 ◽  
Author(s):  
Doris G. Leung ◽  
Harold A. Taylor ◽  
Amanda S. Lindy ◽  
Monica J. Basehore ◽  
Andrew L. Mammen
Keyword(s):  
Creatine Kinase ◽  
Inclusion Body ◽  
Creatine Kinase Level ◽  
Inclusion Body Myositis ◽  
Quadriceps Weakness ◽  
Elevated Creatine Kinase ◽  
Elevated Creatine Kinase Level

scholarly journals A cluster of patients with rhabdomyolysis after eating crayfish

CJEM ◽  
2017 ◽  
Vol 20 (S2) ◽  
pp. S48-S50 ◽  
Author(s):  
Wen-Xuan Yang ◽  
Kit-Ling Fan ◽  
Ling-Pong Leung
Keyword(s):  
Emergency Department ◽  
Creatine Kinase ◽  
Creatine Kinase Level ◽  
Procambarus Clarkii ◽  
Supportive Treatment ◽  
Worldwide Distribution ◽  
Freshwater Crustacean ◽  
Diet History ◽  
Haff Disease ◽  
Elevated Creatine Kinase Level

AbstractCrayfish or Procambarus clarkii is a freshwater crustacean with worldwide distribution. Tons of crayfish are consumed each year. In this report, four adult patients with rhabdomyolysis after consuming crayfish were described. All of them presented to the emergency department with myalgia. The diagnosis of rhabdomyolysis was supported by an elevated creatine kinase level. All recovered with supportive treatment. The clinical picture of these 4 patients was compatible with Haff disease. Haff disease is a syndrome in which rhabdomyolysis develops subsequent to consumption of certain cooked seafood. Crayfish is a common culprit. Diagnosis depends on obtaining a diet history and creatine kinase level. Most patients recover uneventfully with supportive treatment for rhabdomyolysis.

scholarly journals Familial Inclusion Body Myositis (FIBM)

2019 ◽  
Vol 17 (2) ◽  
pp. 193-195
Author(s):  
Marco Orsini ◽  
Mariana Pimentel Mello ◽  
Marcos RG de Freitas ◽  
Osvaldo JM Nascimento
Keyword(s):  
Creatine Kinase ◽  
Inclusion Body ◽  
Inclusion Body Myositis ◽  
Inflammatory Cell ◽  
Late Onset ◽  
Serum Creatine Kinase ◽  
Inflammatory Cell Infiltration ◽  
Cell Infiltration ◽  
Rimmed Vacuoles ◽  
Sporadic Inclusion Body Myositis

Familial inclusion body myositis (FIBM) is extremely rare. The disease is characterized by relatively late onset, selective and early involvement of quadriceps, forearm and finger flexors, only mild increase of serum creatine kinase CK level, frequent rimmed vacuoles in muscle histopathology with substantial inflammatory cell infiltration. The combination of clinical, histological, immunopathological and immunogenetic features indicates that these patients have a disease identical to sporadic inclusion body myositis.

scholarly journals Asymptomatic hyper-creatine-kinase-emia as sole manifestation of inclusion body myositis

2013 ◽  
Vol 5 (2) ◽  
pp. 11 ◽  
Author(s):  
Josef Finsterer ◽  
Claudia Stöllberger ◽  
Gabor G. Kovacs
Keyword(s):  
Creatine Kinase ◽  
Inclusion Body ◽  
Muscle Biopsy ◽  
Nerve Conduction ◽  
Inclusion Body Myositis ◽  
Nerve Conduction Studies ◽  
Differential Diagnoses ◽  
Sporadic Inclusion Body Myositis

Sporadic inclusion body myositis (sIBM) usually manifests with painless weakness of the hand, finger and hip flexors. Absence of symptoms or signs, but mild hyper-CK-emia as the sole manifestation of IBM, has not been reported. We report the case of a 73-year-old male who presented with asymptomatic recurrent hyper-CK-emia ranging from 200 to 1324 U/L (n<171 U/L), since 10 years. Clinical neurologic investigation, nerve conduction studies and EMG were non-informative. Muscle biopsy surprisingly revealed sIBM. sIBM may be asymptomatic and may manifest with hyper-CK-emia exclusively. So, it has to be included in the differential diagnoses of asymptomatic hyper-CK-emia.

scholarly journals Stance control orthosis trial in patients with inclusion body myositis

2011 ◽  
Vol 35 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Kathie Bernhardt ◽  
Terry Oh ◽  
Kenton Kaufman
Keyword(s):  
Inclusion Body ◽  
Inclusion Body Myositis ◽  
Inflammatory Myopathy ◽  
Knee Extensor ◽  
Positive Outcome ◽  
Quadriceps Strength ◽  
Quadriceps Weakness ◽  
Functional Deficits ◽  
Stance Control ◽  
Kinematic Measures

Background: Inclusion Body Myositis (IBM) is an inflammatory myopathy that commonly affects quadriceps strength, resulting in knee buckling and falls. Therefore, patients with IBM should be ideal candidates for stance control orthoses (SCOs).Objectives: Evaluate the effectiveness of SCO use in patients with IBM who have functional deficits due to quadriceps weakness.Study Design: Cohort study.Methods: Nine subjects with IBM were provided a stance control orthosis and followed for six months of home use. All patients had objective testing of their strength and gait and completed a questionnaire at baseline and six months. Gait analysis was performed both with and without the orthosis.Results: Velocity and cadence were lower and step width was higher when using the orthosis. Kinematic measures were largely unchanged with orthosis use. Subjects with less knee extensor weakness had a better outcome than weaker participants. Those who spent more time wearing the orthosis also had a more positive outcome. The participants felt that the SCO was helpful in safeguarding against falls and providing stability.Conclusions: SCO use will benefit patients with IBM, but care should be taken to choose the SCO option that best suits their individual clinical presentation.Clinical relevanceThis is the first study to examine SCO use in the IBM population. Patients with IBM have quadriceps weakness and will potentially benefit from SCO use. This study suggests that successful SCO management of patients with IBM depends on severity of weakness.

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