scholarly journals Association of Metabolic Risk Factors With Cartilage Degradation Assessed by T2 Relaxation Time at the Knee: Data From the Osteoarthritis Initiative

2013 ◽  
Vol 65 (12) ◽  
pp. 1942-1950 ◽  
Author(s):  
P. M. Jungmann ◽  
M. S. Kraus ◽  
H. Alizai ◽  
L. Nardo ◽  
T. Baum ◽  
...  
Keyword(s):  
Risk Factors ◽  
Relaxation Time ◽  
Cartilage Degradation ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Osteoarthritis Initiative

scholarly journals Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative

2014 ◽  
Vol 74 (7) ◽  
pp. 1353-1359 ◽  
Author(s):  
Hans Liebl ◽  
Gabby Joseph ◽  
Michael C Nevitt ◽  
Nathan Singh ◽  
Ursula Heilmeier ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Knee Osteoarthritis ◽  
Case Control ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Knee Oa ◽  
Osteoarthritis Initiative ◽  
Nested Case Control ◽  
Radiographic Knee Osteoarthritis

ObjectiveTo evaluate whether T2 relaxation time measurements obtained at 3 T MRI predict the onset of radiographic knee osteoarthritis (OA).Materials and methodsWe performed a nested case–control study of incident radiographic knee OA in the Osteoarthritis Initiative cohort. Cases were 50 knees with baseline Kellgren–Lawrence (KL) grade of 0 that developed KL grade of 2 or more over a 4-year period. Controls were 80 knees with KL grade of 0 after 4 years of follow-up. Baseline T2 relaxation time measurements and laminar analysis of T2 in deep and superficial layers were performed in all knee compartments. The association of T2 values with incident OA was assessed with logistic regression and differences in T2 values by case–control status with linear regression, adjusting for age, sex, body mass index (BMI) and other covariates.ResultsBaseline T2 values in all compartments except the medial tibia were significantly higher in knees that developed OA compared with controls and were particularly elevated in the superficial cartilage layers in all compartments. There was an increased likelihood of incident knee OA associated with higher baseline T2 values, particularly in the patella, adjusted OR per 1 SD increase in T2 (3.37 (95% CI 1.72 to 6.62)), but also in the medial femur (1.90 (1.07 to 3.39)), lateral femur (2.17 (1.11 to 4.25)) and lateral tibia (2.23 (1.16 to 4.31)).ConclusionsThese findings suggest that T2 values assessed when radiographic changes are not yet apparent may be useful in predicting the development of radiological tibiofemoral OA.

scholarly journals Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: Data from the osteoarthritis initiative

2014 ◽  
Vol 41 (5) ◽  
pp. 1272-1280 ◽  
Author(s):  
Arman T. Serebrakian ◽  
Theresa Poulos ◽  
Hans Liebl ◽  
Gabby B. Joseph ◽  
Andrew Lai ◽  
...  
Keyword(s):  
Weight Loss ◽  
Relaxation Time ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Osteoarthritis Initiative

Knee muscle strength correlates with joint cartilage T2 relaxation time in young participants with risk factors for osteoarthritis

2016 ◽  
Vol 35 (8) ◽  
pp. 2087-2092 ◽  
Author(s):  
Salvador Israel Macías-Hernández ◽  
Antonio Miranda-Duarte ◽  
Isabel Ramírez-Mora ◽  
Socorro Cortés-González ◽  
Juan Daniel Morones-Alba ◽  
...  
Keyword(s):  
Risk Factors ◽  
Relaxation Time ◽  
Muscle Strength ◽  
T2 Relaxation Time ◽  
Joint Cartilage ◽  
T2 Relaxation ◽  
Knee Muscle ◽  
Knee Muscle Strength

scholarly journals 3414 Association of blood pressure and biochemical knee cartilage composition assessed by T2 relaxation time measurements: Data from the Osteoarthritis Initiative

2019 ◽  
Vol 3 (s1) ◽  
pp. 139-140
Author(s):  
Walid Ashmeik ◽  
Gabby B. Joseph ◽  
Michael C. Nevitt ◽  
Nancy E. Lane ◽  
Charles E. McCulloch ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Relaxation Time ◽  
Deep Layer ◽  
Superficial Layer ◽  
T2 Relaxation Time ◽  
Knee Cartilage ◽  
T2 Relaxation ◽  
Knee Oa ◽  
Osteoarthritis Initiative ◽  
Study Participants

OBJECTIVES/SPECIFIC AIMS: The goal of this study was to investigate the associations of systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) with knee articular cartilage composition using magnetic resonance imaging (MRI)-based T2 relaxation time measurements in study participants from the Osteoarthritis Initiative (OAI). METHODS/STUDY POPULATION: In this longitudinal study, 1,139 participants from the OAI, a multi-center, observational study of the evolution of knee OA, were selected using the following inclusion criteria: right knee Kellgren Lawrence (KL) score (radiographic classification of OA severity) 0-2 indicating no to mild radiographic OA at baseline, no history of rheumatoid arthritis at baseline, available blood pressure measurements at baseline, available T2 measurements in at least three knee compartments at baseline and 48-month follow-up. Linear regression models were performed using standardized values for SBP, DBP and PP as primary predictors and change in cartilage T2 over 48 months, a measure of cartilage matrix quality and degeneration, as the primary outcome. PP was defined as SBP minus DBP. Change in superficial layer and deep layer cartilage T2, which reflect differences in the laminar organization of knee cartilage T2, were also included as outcomes. Statistical models were adjusted for common risk factors for knee OA (baseline age, sex, BMI, KL score) as well as number of currently used anti-hypertensive medications (AHM) reported at baseline. We included AHMs whose primary indication was the treatment of hypertension including beta blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARB), thiazides, chlorthalidone, dihydropyridine calcium channel blockers (CCB) and aliskiren. All predictors, outcomes and covariates (except sex) were analyzed as continuous variables. We included interaction terms in the models to evaluate whether the covariates (age, sex, BMI, KL score, number of AHMs) modified the association of SBP, DBP and PP with cartilage T2. RESULTS/ANTICIPATED RESULTS: The average age of all study participants was 58.8 years (SD ± 8.6) with a higher proportion of men (59.4%), average body mass index (BMI) was 28.3 (SD ± 4.5), average SBP was 122.4 (SD ± 15.4) mmHg, average DBP was 75.5 (SD ± 9.6) mmHg and 469 (38.1%) study participants were taking at least one AHM. Higher baseline DBP was significantly associated with a faster increase in global T2 (0.22 [0.10,0.35], P < 0.001), global deep layer T2 (0.20 [0.03,0.36], P < 0.022) and global superficial layer T2 (0.39 [0.20,0.58], P < 0.001). These associations were significant in both unadjusted and the models adjusted for age, sex, BMI and KL score. No significant associations were found between SBP or PP and cartilage T2 and no significant interactions were found between SBP, DBP, PP and the covariates. DISCUSSION/SIGNIFICANCE OF IMPACT: Higher baseline DBP was associated with a faster increase in knee cartilage T2, suggesting accelerated cartilage degeneration. This association was stronger for the superficial layer of knee cartilage T2 compared to the deep layer. Although further basic mechanistic studies are needed to elucidate the underlying pathophysiology of this relationship, these results suggest lowering DBP may influence knee OA.

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