scholarly journals Long-Term Physical Functioning and Its Association With Somatic Comorbidity and Comorbid Depression in Patients With Established Rheumatoid Arthritis: A Longitudinal Study

2013 ◽  
Vol 65 (7) ◽  
pp. 1157-1165 ◽  
Author(s):  
J. van den Hoek ◽  
L. D. Roorda ◽  
H. C. Boshuizen ◽  
J. van Hees ◽  
I. Rupp ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Longitudinal Study ◽  
Physical Functioning ◽  
Established Rheumatoid Arthritis ◽  
Comorbid Depression ◽  
Somatic Comorbidity

scholarly journals A cross-sectional study of sleep and depression in a rheumatoid arthritis population

2020 ◽  
Author(s):  
Mark Hughes ◽  
Alan Chalk ◽  
Poonam Sharma ◽  
Sandeep Dahiya ◽  
James Galloway
Keyword(s):  
Rheumatoid Arthritis ◽  
Sleep Quality ◽  
Cross Sectional Study ◽  
Poor Sleep ◽  
Comorbid Depression ◽  
Poor Sleep Quality ◽  
Cross Sectional ◽  
Rheumatoid Arthritis Population ◽  
Impaired Sleep

Abstract Objectives To assess the prevalence of impaired sleep quality and depression in a rheumatoid arthritis population and determine their correlation with Disease Activity Score (DAS) and its components. Methods In this single-centre observational cross-sectional study, data was collected by the assessing clinician for DAS28, age and gender in various treatment groups according to use of csDMARDs, biologics and long-term steroids. Presence of impaired sleep quality and depression was assessed by the Pittsburgh Sleep Quality Index (PSQI) and Public Health Questionnaire 9 (PHQ 9). Correlation for DAS and its components with the outcomes was determined by Pearson’s correlation coefficient. Multivariate analysis was performed by logistic regression. Results Two hundred patients were included. The prevalence across all subgroups of poor sleep quality and depression were 86.5% and 30%, respectively, with a correlation coefficient of 0.69 between the two and poor sleep quality amongst all RA patients with comorbid depression. Multivariate analysis found only subjective DAS components, tender joint count (TJC) and patient global health visual analogue score (VAS) to significantly correlate with both outcomes. Age inversely correlated with depression. Long-term steroid use was associated with poorer sleep quality, but there was no significant effect of csDMARDs or biologics. There was no significant difference in prevalence of depression amongst treatment subgroups. Conclusion Poor sleep quality and to a lesser extent depression are prevalent in the general rheumatoid arthritis population. Patients would benefit from clinicians measuring these outcomes routinely as they constitute a significant non-inflammatory burden of living with rheumatoid disease. Key Points• Subjective components of DAS independently correlate with sleep quality and depression, while objective components do not.• Poor sleep quality is highly prevalent in RA and present in all those with comorbid depression.• Poor sleep quality and depression incidence in RA are much lower when DAS is low or remission.

scholarly journals Association between pain phenotype and disease activity in rheumatoid arthritis patients: a non-interventional, longitudinal cohort study

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
P. M. ten Klooster ◽  
N. de Graaf ◽  
H. E. Vonkeman
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Longitudinal Study ◽  
Disease Activity ◽  
Joint Damage ◽  
Nociceptive Pain ◽  
Tender Joint Count ◽  
Tender Joint ◽  
Comorbid Diseases

Abstract Background In well-controlled rheumatoid arthritis (RA) without significant joint damage, a substantial proportion of patients complain of persistent pain. Previous studies have identified different pain phenotypes in RA, in which non-nociceptive pain phenotypes are associated with higher concurrent disease activity scores. In this longitudinal study, we explored associations between pain phenotypes and long-term disease activity outcome in RA patients. Secondly, we explored whether pain phenotype is associated with comorbid conditions. Methods One hundred eighty established RA patients were classified with a nociceptive (61%) or a non-nociceptive (39%) pain phenotype, based on their responses to the painDETECT-questionnaire. Two years of clinical follow-up data on disease activity outcomes were collected. Information on comorbid diseases was derived from electronic patient files. Results Patients with a non-nociceptive pain phenotype showed higher mean disease activity scores (DAS28, 2.57; 95% CI, 2.37–2.77 vs. 2.11; 95% CI, 1.94–2.27; p < 0.001) and a twofold lower chance of achieving sustained DAS28 remission (OR = 0.49; 95% CI, 0.26–0.92; p = 0.020). Only the tender joint count and patient global health significantly differed between the pain phenotype groups. Patients with a non-nociceptive pain phenotype had more often been diagnosed with concurrent fibromyalgia (9.9% vs. 0.9%; p = 0.007) and other pain-associated comorbid diseases (52.1% vs. 35.8%; p = 0.030) compared with patients with a nociceptive pain phenotype. Conclusion This longitudinal study showed consistently worse long-term disease activity outcomes in RA patients with a non-nociceptive pain phenotype which appeared to be mainly due to differences in the subjective components of the disease activity score. Trial registration The DREAM cohort study is registered in the Netherlands Trial Register: NTR578.

Tender Joint Count and Inflammatory Activity in Patients With Established Rheumatoid Arthritis: Results From a Longitudinal Study

2019 ◽  
Vol 72 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Hilde B. Hammer ◽  
Brigitte Michelsen ◽  
Sella A. Provan ◽  
Joe Sexton ◽  
Jon Lampa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Longitudinal Study ◽  
Inflammatory Activity ◽  
Tender Joint Count ◽  
Established Rheumatoid Arthritis ◽  
Tender Joint
Sign in / Sign up

Export Citation Format

Share Document