scholarly journals Increased Risk of Arthropathies and Joint Replacement Surgery in Patients With Genetic Hemochromatosis: A Study of 3,531 Patients and Their 11,794 First-Degree Relatives

2013 ◽  
Vol 65 (5) ◽  
pp. 678-685 ◽  
Author(s):  
Maria Elmberg ◽  
Rolf Hultcrantz ◽  
Julia F. Simard ◽  
Åke Carlsson ◽  
Johan Askling
Keyword(s):  
Joint Replacement ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
First Degree Relatives ◽  
Increased Risk ◽  
Genetic Hemochromatosis

160 - Anti-TNF Inhibitors are not Associated with Increased Risk of Infection after Joint Replacement Surgery

2018 ◽  
Vol 154 (6) ◽  
pp. S-44-S-45
Author(s):  
Martin H. Gregory ◽  
Andrew McKinnon ◽  
Dustin Stwalley ◽  
Edward V. Loftus ◽  
K.J. Hippensteel ◽  
...  
Keyword(s):  
Joint Replacement ◽  
Tnf Inhibitors ◽  
Risk Of Infection ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Increased Risk

scholarly journals Venous thromboembolism in patients hospitalized for knee joint replacement surgery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Karsten Keller ◽  
Lukas Hobohm ◽  
Stefano Barco ◽  
Irene Schmidtmann ◽  
Thomas Münzel ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Knee Joint ◽  
Joint Replacement ◽  
Nationwide Inpatient Sample ◽  
Annual Number ◽  
Hospital Death ◽  
Knee Joint Replacement ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Increased Risk

AbstractPatients undergoing knee joint replacement (KJR) are at high risk of postoperative venous thromboembolism (VTE), but data on the time trends of VTE rate in this population are sparse. In this analysis of the German nationwide inpatient sample, we included all hospitalizations for elective primary KJR in Germany 2005–2016. Overall, 1,804,496 hospitalized patients with elective primary KJR (65.1% women, 70.0 years [IQR 63.0–76.0]) were included in the analysis. During hospitalization, VTE was documented in 23,297 (1.3%) patients. Total numbers of primary KJR increased from 129,832 in 2005 to 167,881 in 2016 (β-(slope)-estimate 1,978 [95% CI 1,951 to 2,004], P < 0.001). In-hospital VTE decreased from 2,429 (1.9% of all hospitalizations for KJR) to 1,548 (0.9%) cases (β-estimate − 0.77 [95% CI − 0.81 to − 0.72], P < 0.001), and in-hospital death rate from 0.14% (184 deaths) to 0.09% (146 deaths) (β-estimate − 0.44 deaths per year [95% CI − 0.59 to − 0.30], P < 0.001). Infections during hospitalization were associated with a higher VTE risk. VTE events were independently associated with in-hospital death (OR 20.86 [95% CI 18.78–23.15], P < 0.001). Annual number of KJR performed in Germany increased by almost 30% between 2005 and 2016. In parallel, in-hospital VTE rates decreased from 1.9 to 0.9%. Perioperative infections were associated with higher risk for VTE. Patients who developed VTE had a 21-fold increased risk of in-hospital death.

scholarly journals Progress in Prevention, Diagnosis, and Treatment of Periprosthetic Joint Infection

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Kai Wang ◽  
Wei Li ◽  
Huayu Liu ◽  
Yang Yang ◽  
Lingyun Lv
Keyword(s):  
Joint Replacement ◽  
Periprosthetic Joint Infection ◽  
Total Joint Replacement ◽  
Joint Infection ◽  
Diagnostic Methods ◽  
Diagnosis And Treatment ◽  
High Morbidity ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Increased Risk

Periprosthetic joint infection (PJI) after joint replacement surgery is a severe complication associated with high morbidity and increased treatment costs. More than 25% of joint implant failures are attributed to PJI. PJI diagnosis and treatment methods have substantially improved in recent years. However, the prevalence of PJI remains high, primarily due to the increased prevalences of obesity, diabetes, and other underlying conditions. Moreover, increasing elderly prefers to total joint replacement surgery. However, due to frailty and comorbidities, most are at increased risk of infectious arthritis and artificial joint infection (PJI). Therefore, PJI management for the elderly requires multilevel and multiangle intervention. In this review, we summarize the risk factors and diagnostic methods currently available for PJI and discuss the current PJI prevention and treatment interventions, especially the management in older adults.

Association of joint replacement surgery with incident dementia diagnosis in German claims data

2018 ◽  
Vol 30 (9) ◽  
pp. 1375-1383 ◽  
Author(s):  
Stefan J. Teipel ◽  
Thomas Fritze ◽  
Martin Ellenrieder ◽  
Britta Haenisch ◽  
Wolfram Mittelmeier ◽  
...  
Keyword(s):  
Joint Replacement ◽  
Claims Data ◽  
Incidence Rates ◽  
Dementia Diagnosis ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Incident Dementia ◽  
Increased Risk ◽  
Incident Cases

ABSTRACTBackground:Cognitive decline is an important complication of joint replacement surgeries in senior people.Methods:We determined incidence rates of dementia diagnosis following endoprosthetic joint replacement surgery (upper and lower extremities). The observation period covered up to 28 quarters using German claims data comprising 154,604 cases 65 years and older. Effects were controlled for cerebrovascular and vascular risk factors, age, sex, the presence of a diagnosis of delirium, and regular prescription of sedative or analgesic drugs (SAD).Results:The rate of incident dementia diagnoses in people without joint replacement surgery was 21.34 per 1,000 person years, compared with 80.76 incident cases when joint replacement surgery was conducted during the quarter of the incident dementia diagnosis; rates declined to 21.77 incident cases 7 and more quarters after joint replacement surgery had taken place. This pattern was maintained when controlling for delirium diagnosis and regular prescription of SAD. Among 10,563 patients with at least one joint replacement surgery, patients with a diagnosis of delirium in the quarter of the surgery were at increased risk of a dementia diagnosis compared to patients without such a diagnosis (HR=2.00, p < 0.001).Conclusion:In people surviving the high-risk phase for dementia immediately after surgery, long-term risk of dementia may reach the level of those without surgery. These findings encourage consequent perioperative management to reduce the risk of dementia as well as prospective studies of potentially beneficial effects of joint replacement surgery on mid- to long-term recovery of mobility and cognition in geriatric patients.

scholarly journals Anti-Phospholipid Antibodies in Patients Undergoing Total Joint Replacement Surgery

Thrombosis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Melissa Simpson ◽  
Michael J. Sanfelippo ◽  
Adedayo A. Onitilo ◽  
James K. Burmester ◽  
William Hocking ◽  
...  
Keyword(s):  
Joint Replacement ◽  
Total Joint Replacement ◽  
Patient Specific ◽  
Preoperative Period ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Increased Risk ◽  
Patients At Risk ◽  
Total Knee ◽  
Arthroplasty Procedure

Background. Patients undergoing joint replacement remain at increased risk for venous thromboembolism (VTE) compared to other types of surgery, regardless of thromboprophylactic regimen. The pathophysiologic processes rendering this group of patients at risk for VTE are multifactorial. Procedure-specific and patient-specific exposures play a role in the postoperative development of VTE, including the development of anti-phospholipid antibodies (aPL). Methods. We measured three aPL (anti-cardiolipin, anti-β2 glycoprotein, and lupus anticoagulant) in 123 subjects undergoing total knee or hip arthroplasty to describe the presence of these antibodies preoperatively and to describe the rate of postoperative seroconversion among those people who were negative preoperatively. Postoperative antibodies were measured at day 7, 14, and 21. Results. The prevalence of aPL antibodies in the preoperative period was 44%, positive subjects were more likely to be smokers (P=0.05) and were less likely to have undergone a previous arthroplasty procedure (P=0.002). Subjects seroconverted in a 21 day postoperative period at a rate of 79%. Conclusions. These pilot data suggest that the prevalence of aPL in this population both preoperatively and postoperatively is higher than previously expected. Further studies are needed to describe aPL in a larger population and to establish their clinical significance in populations undergoing joint replacement surgeries.

scholarly journals COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operatively

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Marco S. Caicedo ◽  
Vianey Flores ◽  
Alicia Padilla ◽  
Samelko Lauryn ◽  
Joshua J. Jacobs ◽  
...  
Keyword(s):  
Joint Replacement ◽  
Total Joint Replacement ◽  
Cross Reactivity ◽  
Inflammatory Biomarkers ◽  
Nucleocapsid Proteins ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Operative Planning ◽  
Lymphocyte Responses ◽  
Reactive Lymphocytes

Abstract Background Recent studies indicate that, in addition to antibody production, lymphocyte responses to SARS-CoV-2 may play an important role in protective immunity to COVID-19 and a percentage of the general population may exhibit lymphocyte memory due to unknown/asymptomatic exposure to SARS-CoV-2 or cross-reactivity to other more common coronaviruses pre-vaccination. Total joint replacement (TJR) candidates returning to elective surgeries (median age 68 years) may exhibit similar lymphocyte and/or antibody protection to COVID-19 prior to vaccination Methods In this retrospective study, we analyzed antibody titters, lymphocyte memory, and inflammatory biomarkers specific for the Spike and Nucleocapsid proteins of the SARS-CoV-2 virus in a cohort of n=73 returning TJR candidates (knees and/or hips) pre-operatively. Results Peripheral blood serum of TJR candidate patients exhibited a positivity rate of 18.4% and 4% for IgG antibodies specific for SARS-CoV-2 nucleocapsid and spike proteins, respectively. 13.5% of TJR candidates exhibited positive lymphocyte reactivity (SI > 2) to the SARS-CoV-2 nucleocapsid protein and 38% to the spike protein. SARS-CoV-2 reactive lymphocytes exhibited a higher production of inflammatory biomarkers (i.e., IL-1β, IL-6, TNFα, and IL-1RA) compared to non-reactive lymphocytes. Conclusions A percentage of TJR candidates returning for elective surgeries exhibit pre-vaccination positive SARS-CoV-2 antibodies and T cell memory responses with associated pro-inflammatory biomarkers. This is an important parameter for understanding immunity, risk profiles, and may aid pre-operative planning. Trial registration Retrospectively registered.

scholarly journals Meaningful changes for the Oxford hip and knee scores after joint replacement surgery

2015 ◽  
Vol 68 (1) ◽  
pp. 73-79 ◽  
Author(s):  
David J. Beard ◽  
Kristina Harris ◽  
Jill Dawson ◽  
Helen Doll ◽  
David W. Murray ◽  
...  
Keyword(s):  
Joint Replacement ◽  
Joint Replacement Surgery ◽  
Replacement Surgery

Quantifying function before and after total joint replacement surgery in patients with hip osteoarthritis

2015 ◽  
Vol 42 ◽  
pp. S32
Author(s):  
J.E. Naili ◽  
A.C. Esbjörnsson ◽  
M.D. Iversen ◽  
M.H. Schwartz ◽  
C. Häger ◽  
...  
Keyword(s):  
Joint Replacement ◽  
Total Joint Replacement ◽  
Hip Osteoarthritis ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Before And After
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