scholarly journals Tibialis Posterior Tenosynovitis and Associated Pes Plano Valgus in Rheumatoid Arthritis: Electromyography, Multisegment Foot Kinematics, and Ultrasound Features

2013 ◽  
Vol 65 (4) ◽  
pp. 495-502 ◽  
Author(s):  
Ruth Barn ◽  
Deborah E. Turner ◽  
Daniel Rafferty ◽  
Roger D. Sturrock ◽  
James Woodburn
Keyword(s):  
Rheumatoid Arthritis ◽  
Tibialis Posterior ◽  
Foot Kinematics ◽  
Pes Plano Valgus ◽  
Ultrasound Features

ULTRASONOGRAPHY OF THE TIBIALIS POSTERIOR TENDON IN RHEUMATOID ARTHRITIS

Rheumatology ◽  
1994 ◽  
Vol 33 (3) ◽  
pp. 273-277 ◽  
Author(s):  
F. V. COAKLEY ◽  
A. K. SAMANTA ◽  
D. B. FINLAY
Keyword(s):  
Rheumatoid Arthritis ◽  
Tibialis Posterior ◽  
Tibialis Posterior Tendon

scholarly journals POS0578 CORRELATION BETWEEN EXPRESSION LEVELS OF MIR-155 AND MIR-223 IN SYNOVIAL FLUID AND ULTRASOUND SCORES FOR ACTIVE SYNOVITIS IN RHEUMATOID ARTHRITIS PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 522.3-523
Author(s):  
R. Shumnalieva ◽  
D. Kachakova ◽  
R. Kaneva ◽  
Z. Kolarov ◽  
S. Monov
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Expression ◽  
Clinical Practice ◽  
Synovial Fluid ◽  
Disease Activity ◽  
Power Doppler ◽  
Joint Inflammation ◽  
Expression Levels ◽  
Ultrasound Features ◽  
Local Expression

Background:MicroRNAs (miRNAs) are a class of small, non-coding RNAs that negatively regulate gene expression at posttranscriptional level. In rheumatoid arthritis studies have shown that miRNA are differentially expressed systemically as well as locally in the inflamed joints [1,2]. The correlation between their systemic or local expression levels and scores for disease activity and progression in RA make them possible candidate for biomarkers in the clinical practice.Objectives:To analyze the expression levels of miR-155 and miR-223 in synovial fluid (SF) from RA patients in regard to the ultrasound scores for disease activity.Methods:A total number of 48 RA patients according to the 1987 ACR criteria were included in the study. Expression levels of miR-155 and miR-223 SF were determined by qPCR (SybrGreen technology) and compared to healthy controls (HCs). Relative changes of gene expression levels of the studied miRNAs were calculated by 2-ΔΔCt method. Musculoskeletal ultrasound (MSUS) examination was performed by two independent examiners on ESAOTE, MyLab60 using both grey scale and power Doppler technic. A semi-quantitative assessment of the peripheral joints was performed for detecting joint inflammation and determining the grade of synovial thickening and the degree of vascularization. Ultrasound features for active disease were correlated to the local expression of the studied miRNAs. SPSS was used for statistical analysis.Results:RA SF showed overexpression of miR-155 (in 79.17%, p=1.63x10-4) and of miR-223 (in 79.17%, p=1.64x10-3) when compared to HCs and both miRNAs could be used to differentiate RA patients from HCs (р=8.0х10-5 and р=2.8х10-4, respectively). When we analyzed the correlation between the diagnosis, the expression of miRNAs and the changes on the musculoskeletal ultrasound examination we found a statistically significant correlation between the presence of synovitis and the degree of the power Doppler signal on MSUS and the local expression of miR-223 (p=6.19 x 10-4 and p=0.003, respectively). SF levels of miR-223 correlated also with the degree of synovial hypertrophy on MSUS (p=0.013). The results for miRNA-155 were not statistically significant.Conclusion:The correlation between the local expression of miR-223 and the ultrasound features of active joint inflammation shows that this miRNA might be a better candidate for local disease biomarker than miR-155. Further analysis with larger sets is needed to confirm if altered local miRNA expression could be used in the clinical practice as biomarker for disease activity especially in cases with subclinical synovitis.References:[1]Filková M, Aradi B, Šenolt L, et al. Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis. ARD, 2014; 73: 1898-1904.[2]Kriegsmann, M., Randau, T.M., Gravius, S. et al. Expression of miR-146a, miR-155, and miR-223 in formalin-fixed paraffin-embedded synovial tissues of patients with rheumatoid arthritis and osteoarthritis. Virchows Arch, 2016; 469, 93–100.Acknowledgements:The study was supported by Grant 14-D/2012 and Grant 60/2013 funded by Medical University-Sofia.Disclosure of Interests:Russka Shumnalieva: None declared, Darina Kachakova: None declared, Radka Kaneva: None declared, Zlatimir Kolarov Speakers bureau: Amgen, Pfizer, Novartis, Abbvie, Roche, Astra-Zeneka, Simeon Monov Speakers bureau: Amgen, Pfizer, Novartis, Abbvie, Roche, Astra-Zeneka

scholarly journals Isolated talonavicular arthrodesis in patients with rheumatoid arthritis of the foot and tibialis posterior tendon dysfunction

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Stanislav Popelka ◽  
Rastislav Hromádka ◽  
Pavel Vavřík ◽  
Pavel Štursa ◽  
David Pokorný ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tibialis Posterior ◽  
Tibialis Posterior Tendon

Pathological foot kinematics in subjects with stage II tibialis posterior dysfunction using a multisegmented foot model

2015 ◽  
Vol 42 ◽  
pp. S12
Author(s):  
B. Callewaert ◽  
K. Deschamps ◽  
K. Desloovere ◽  
D. Monari ◽  
F. Staes ◽  
...  
Keyword(s):  
Stage Ii ◽  
Tibialis Posterior ◽  
Foot Kinematics ◽  
Foot Model

Posterior Tibial Tendon and Spring Ligament Lesions in Rheumatoid Arthritis

2019 ◽  
Vol 35 (4) ◽  
pp. 65-69
Author(s):  
M. Bouysset ◽  
T. Tavernier ◽  
E. Decullier ◽  
C. Confavreux ◽  
J.G. Tebib ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tibialis Posterior ◽  
Posterior Tibial Tendon ◽  
Treatment Intensification ◽  
Flat Foot ◽  
Biologic Treatment ◽  
Posterior Tibial ◽  
Spring Ligament ◽  
Number Of Patients ◽  
Tendon Lesion

In rheumatoid arthritis, a significant number of patients have hindfoot pain while they are considered in low disease activity. Then the rheumatoid hindfoot may evolve in valgus flat foot with disability. The aim of our study was to observe the lesions of the main stabilizers of the hindfoot in rheumatoid arthritis to improve the followup and the treatment of the disease. Thirty-three feet (from 21 patients) with rheumatoid arthritis and pain of the hindfoot were consecutively observed. The patients have had no biologic treatment. Every foot had Magnetic Resonance Imaging (MRI) of the hindfoot with gadolinium injection. The tendon of the tibialis posterior muscle, the spring ligament and the inter-osseous talocalcaneal ligament were considered. All the feet presented tenosynovitis of the posterior tibial tendon. Structural lesions of the posterior tibial tendon (23/33 feet, 69.7%) were more frequent than lesions of the spring ligament (12/33 feet, 36.4%). There was no inferior spring ligament lesion without superior spring ligament lesion. No interosseous talocalcaneal ligament lesion was observed. In rheumatoid arthritis, the hindfoot, and particularly the posterior tibial tendon, should be evaluated during patient follow-up to detect a possible lesion. Posterior tibial tendon lesion arises at the same time as the spring ligament lesion, before interosseous talocalcaneal ligament lesion. Imaging, especially MRI, may complete clinical examination. If rheumatoid involvement of the posterior tibial tendon is observed, treatment intensification is required.

scholarly journals Ankle involvement in rheumatoid arthritis – a comparison of inflammatory signs on musculoskeletal ultrasound and magnetic resonance imaging

2019 ◽  
Vol 21 (3) ◽  
pp. 265
Author(s):  
Luminita Enache ◽  
Claudiu Costinel Popescu ◽  
Mihaela Micu ◽  
Adriana Cojocaru ◽  
Victoria-Cristina Suta ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Sensitivity And Specificity ◽  
Power Doppler ◽  
Joint Involvement ◽  
Tibialis Posterior ◽  
Resonance Imaging ◽  
Inflammatory Lesions ◽  
Good Agreement

Aim: To evaluate the frequency of tibiotalar and subtalar joints together with extensor, flexor and peroneal tendons inflammatory lesions in rheumatoid arthritis (RA) patients by using ultrasound (US) and magnetic resonance imaging (MRI).Material and methods. Fifty RA patients and 25 healthy subjects were prospectively included. All patients and controlsunderwent clinical examination (to screen for swollen and/or tender ankles) and ankle US and MRI (to screen for synovialhypertrophy – SH, tenosynovitis and power Doppler – PD signals). The imaging tests were compared using overall agreement, positive agreement, Cohen’s κ, sensitivity, specificity and positive likelihood ratio.Results. The subtalar joint had the highest frequency of US-detected SH (30%), as well as positive PD signals (10%). Regarding US joint effusion, the tibiotalar joint recorded the highest frequency (44%). The most frequent US tenosynovitis was detected in the tibialis posterior tendon (40%). Compared to MRI, US evaluation of tibiotalar joints had very good agreement and large effect on detection probability for both SH and effusion (kappa 0.84, positive likelihood ratio 21.1). Compared to MRI, the sensitivity and specificity for US joint involvement ranged between 72.0-88.5% and 82.4-95.8%, and for tenosynovitis were 33.3-78.6% and 85.2-100%,  respectively. Compared to asymptomatic RA patients (n=25), those with at least one symptomatic ankle (n=25) had significantly higher frequencies of both SH and effusion in all the evaluated structures.Conclusion: US has high sensitivity and specificity in detecting RA inflammatory lesions in the ankle and rearfoot, in very good agreement with MRI. The high frequency of ankle inflammatory lesions in RA should result in increased interest in the imaging evaluation of these structures.

A parametric study of effect of experimental tibialis posterior muscle pain on joint loading and muscle forces—Implications for patients with rheumatoid arthritis?

2019 ◽  
Vol 72 ◽  
pp. 102-108 ◽  
Author(s):  
Morten Bilde Simonsen ◽  
Aysun Yurtsever ◽  
Ketill Næsborg-Andersen ◽  
Peter Derek Christian Leutscher ◽  
Kim Hørslev-Petersen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Parametric Study ◽  
Muscle Pain ◽  
Tibialis Posterior ◽  
Muscle Forces ◽  
Joint Loading
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