scholarly journals Initial evaluation of an ultrasound measure for assessing the activity of skin lesions in juvenile localized scleroderma

2011 ◽  
Vol 63 (5) ◽  
pp. 735-742 ◽  
Author(s):  
S. C. Li ◽  
M. S. Liebling ◽  
K. A. Haines ◽  
J. E. Weiss ◽  
A. Prann
Keyword(s):  
Skin Lesions ◽  
Initial Evaluation ◽  
Localized Scleroderma ◽  
Juvenile Localized Scleroderma

scholarly journals Juvenile Localized Scleroderma. Questions of Treatment

2020 ◽  
Vol 19 (3) ◽  
pp. 228-234
Author(s):  
Rinat K. Raupov ◽  
Mikhail M. Kostik
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Treatment Efficacy ◽  
Active Phase ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Resonance Imaging ◽  
Childhood Diseases ◽  
Main Symptom ◽  
Juvenile Localized Scleroderma

Juvenile localized scleroderma (JLS) is a group of childhood diseases with the main symptom — skin and subcutaneous structures lesions, without any organ involvement. There is active (inflammatory) and fibrotic phase in development of JLS. The JLS treatment during active phase (when skin lesions are reversible) is the most effective. The management is determined by the area and depth of skin lesions, appearance and spread of new lesions, presence of extracutaneous signs of the disease. Topical and systemic immunosuppressants are the basic therapy for JLS. The use of antibiotics is not suggested. Clinical scores (LoSCAT), ultrasound, thermography and magnetic resonance imaging are recommended to estimate the treatment efficacy.

scholarly journals Juvenile localized scleroderma: clinical and epidemiological features in 750 children. An international study

Rheumatology ◽  
2005 ◽  
Vol 45 (5) ◽  
pp. 614-620 ◽  
Author(s):  
F. Zulian ◽  
B. H. Athreya ◽  
R. Laxer ◽  
A. M. Nelson ◽  
S. K. Feitosa de Oliveira ◽  
...  
Keyword(s):  
International Study ◽  
Localized Scleroderma ◽  
Epidemiological Features ◽  
Juvenile Localized Scleroderma

Juvenile localized scleroderma: Is it a benign disease?

2017 ◽  
Vol 24 (3) ◽  
pp. 145-152
Author(s):  
Christine Arango ◽  
Clara Malagón ◽  
María del Pilar Gómez ◽  
Catalina Mosquera ◽  
Ricardo Yépez ◽  
...  
Keyword(s):  
Benign Disease ◽  
Localized Scleroderma ◽  
Juvenile Localized Scleroderma

scholarly journals Juvenile localized scleroderma with autoimmune thyroid disorder

2010 ◽  
Vol 55 (3) ◽  
pp. 308 ◽  
Author(s):  
PrabhakarM Sangolli ◽  
NC Hiremath ◽  
NT Madan Mohan ◽  
C Srinivas ◽  
K Srinivas ◽  
...  
Keyword(s):  
Localized Scleroderma ◽  
Thyroid Disorder ◽  
Autoimmune Thyroid ◽  
Autoimmune Thyroid Disorder ◽  
Juvenile Localized Scleroderma

scholarly journals Gender, clinical and topographic features of the localized scleroderma lesions in anogenital area

2020 ◽  
Vol 23 (3) ◽  
pp. 165-173
Author(s):  
Elena S. Snarskaya ◽  
Yulia A. Semenchak
Keyword(s):  
Clinical Symptoms ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Steady Increase ◽  
Family Doctors ◽  
Topographic Features ◽  
Anogenital Area ◽  
Clinical Variants ◽  
Limited Scleroderma ◽  
And Gender

Background: Currently, there is an increase in the number of skin lesions of anogenital localization, which is a silent epidemic, both due to the steady increase in the incidence of this pathology, and the interdisciplinary aspect of this problem. Materials and methods: In the article, the authors first analyzed and presented the data of clinical and morphological analysis of 104 patients with various clinical variants of limited scleroderma, on the basis of which the main phenotypic and gender-specific clinical and topographical features of anogenital zone lesions in this group of patients are presented. Results: Scleroatrophic lichen is one of the clinical variants of limited scleroderma, which is characterized by damage to the mucous membranes of the external genitals in both women and men. Lesions of such localization are late and often mistakenly diagnosed by specialists of related disciplines (obstetricians, gynecologists, urologists, family doctors, allergists, cosmetologists), which leads to high risks of developing genitourenal syndrome. Conclusions: The development of scleroatrophic lesions in the anogenital zone is accompanied by pronounced clinical symptoms, including: itching, pain of varying intensity, dysuria, dyspareunia and significant sexual dysfunction.

Localized scleroderma manifesting with skin lesions associated with mechanical stress

2019 ◽  
Vol 29 (4) ◽  
pp. 439-440
Author(s):  
Satoshi Toyama ◽  
Shinichi Sato ◽  
Yoshihide Asano
Keyword(s):  
Mechanical Stress ◽  
Skin Lesions ◽  
Localized Scleroderma

scholarly journals Initial Results from a Pilot Comparative Effectiveness Study of 3 Methotrexate-based Consensus Treatment Plans for Juvenile Localized Scleroderma

2019 ◽  
Vol 47 (8) ◽  
pp. 1242-1252 ◽  
Author(s):  
Suzanne C. Li ◽  
Kathryn S. Torok ◽  
C. Egla Rabinovich ◽  
Fatma Dedeoglu ◽  
Mara L. Becker ◽  
...  
Keyword(s):  
Comparative Effectiveness ◽  
Activity Level ◽  
Effective Control ◽  
Localized Scleroderma ◽  
Disease Extent ◽  
Response Level ◽  
Childhood Arthritis ◽  
Treatment Regimens ◽  
Treatment Plans ◽  
Juvenile Localized Scleroderma

Objective.To perform a comparative effectiveness feasibility study in juvenile localized scleroderma (LS), using standardized treatment regimens (consensus treatment plans; CTP).Methods.A prospective, multicenter 1-year pilot observational cohort study was performed by Childhood Arthritis and Rheumatology Research Alliance (CARRA) LS workgroup members. Patients with active, moderate to severe juvenile LS were treated with one of 3 CTP: methotrexate alone, or in combination with intravenous (30 mg/kg/dose for 3 mos) or oral corticosteroids (2 mg/kg/day tapered by 48 weeks).Results.Fifty patients, with demographics typical for juvenile LS, were enrolled, and 44 (88%) completed the study. Most had extracutaneous involvement. Patients improved in all 3 CTP, with > 75% having a major or moderate level of improvement compared to baseline. Damage accrued in some patients. Major deviations from prescribed regimen resulted from medication intolerance (n = 6; 14%) or treatment failure (n = 11; 25%); failures occurred in all 3 CTP. Significant responses to treatment were demonstrated by LS skin scoring measures and overall physician assessments, with differences in response level identified in some patient subsets. Response differences were associated with baseline disease activity level, LS subtype, skin disease extent, and extracutaneous involvement.Conclusion.This study demonstrates the feasibility of conducting juvenile LS comparative effectiveness studies. The CTP were found to be safe, effective, and tolerable. Our assessments performed well. Because damage is common and may progress despite effective control of activity, we recommend initial treatment efficacy be evaluated primarily by activity measures. Potential confounders for response were identified that warrant further study.

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