scholarly journals Outcomes in recent-onset inflammatory polyarthritis differ according to initial titers, persistence over time, and specificity of the autoantibodies

2010 ◽  
Vol 62 (11) ◽  
pp. 1624-1632 ◽  
Author(s):  
Marie-Caroline Guzian ◽  
Nathalie Carrier ◽  
Pierre Cossette ◽  
Artur J. de Brum-Fernandes ◽  
Patrick Liang ◽  
...  
Keyword(s):  
Recent Onset ◽  
Inflammatory Polyarthritis ◽  
Over Time

Influence of age and sex on functional outcome over time in a cohort of patients with recent-onset inflammatory polyarthritis: Results from the Norfolk arthritis register

2011 ◽  
Vol 63 (12) ◽  
pp. 1745-1752 ◽  
Author(s):  
Elizabeth M. Camacho ◽  
Suzanne M. M. Verstappen ◽  
Mark Lunt ◽  
Diane K. Bunn ◽  
Deborah P. M. Symmons
Keyword(s):  
Functional Outcome ◽  
Recent Onset ◽  
Inflammatory Polyarthritis ◽  
Over Time ◽  
Age And Sex

Improvement in prefrontal thalamic connectivity during the early course of the illness in recent-onset psychosis: a 12-month longitudinal follow-up resting-state fMRI study

2020 ◽  
pp. 1-9
Author(s):  
Daniel Bergé ◽  
Tyler A. Lesh ◽  
Jason Smucny ◽  
Cameron S. Carter
Keyword(s):  
Resting State ◽  
Resting State Fmri ◽  
Functional Changes ◽  
Recent Onset ◽  
Fmri Study ◽  
Clinical Meaning ◽  
Mixed Pattern ◽  
The Right ◽  
Over Time

Abstract Background Previous research in resting-state functional magnetic resonance imaging (rs-fMRI) has shown a mixed pattern of disrupted thalamocortical connectivity in psychosis. The clinical meaning of these findings and their stability over time remains unclear. We aimed to study thalamocortical connectivity longitudinally over a 1-year period in participants with recent-onset psychosis. Methods To this purpose, 129 individuals with recent-onset psychosis and 87 controls were clinically evaluated and scanned using rs-fMRI. Among them, 43 patients and 40 controls were re-scanned and re-evaluated 12 months later. Functional connectivity between the thalamus and the rest of the brain was calculated using a seed to voxel approach, and then compared between groups and correlated with clinical features cross-sectionally and longitudinally. Results At baseline, participants with recent-onset psychosis showed increased connectivity (compared to controls) between the thalamus and somatosensory and temporal regions (k = 653, T = 5.712), as well as decreased connectivity between the thalamus and left cerebellum and right prefrontal cortex (PFC; k = 201, T = −4.700). Longitudinal analyses revealed increased connectivity over time in recent-onset psychosis (relative to controls) in the right middle frontal gyrus. Conclusions Our results support the concept of abnormal thalamic connectivity as a core feature in psychosis. In agreement with a non-degenerative model of illness in which functional changes occur early in development and do not deteriorate over time, no evidence of progressive deterioration of connectivity during early psychosis was observed. Indeed, regionally increased connectivity between thalamus and PFC was observed.

OP0088 Changes in Baseline Severity of Inflammatory Polyarthritis Over Time

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A80.1-A80
Author(s):  
J. Diffin ◽  
M. Lunt ◽  
T. Marshall ◽  
J. Chipping ◽  
D. Symmons ◽  
...  
Keyword(s):  
Baseline Severity ◽  
Inflammatory Polyarthritis ◽  
Over Time

scholarly journals Has the Severity of Rheumatoid Arthritis at Presentation Diminished Over Time?

2014 ◽  
Vol 41 (8) ◽  
pp. 1590-1599 ◽  
Author(s):  
Janet G. Diffin ◽  
Mark Lunt ◽  
Tarnya Marshall ◽  
Jacqueline R. Chipping ◽  
Deborah P.M. Symmons ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Drug Exposure ◽  
Functional Disability ◽  
Health Assessment ◽  
Joint Disease ◽  
Symptom Duration ◽  
Recent Onset ◽  
American College Of Rheumatology ◽  
Over Time

Objective.To examine the pattern of disease severity in patients with rheumatoid arthritis (RA) at presentation to the Norfolk Arthritis Register (NOAR) over 20 years.Methods.NOAR is a primary-care–based cohort of patients with recent-onset inflammatory polyarthritis. At baseline, subjects are assessed and examined by a research nurse. The Health Assessment Questionnaire (HAQ) is administered and the DAS28 (28-joint Disease Activity Score) is calculated. Information is collected on disease-modifying antirheumatic drug exposure. In this study, patients (symptom duration of < 2 years at baseline) were grouped into 4 cohorts (Cohort 1: 1990–1994; Cohort 2: 1995–1999; Cohort 3: 2000–2004; Cohort 4: 2005–2008). The American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 2010 criteria for RA were applied retrospectively at baseline. Regression analyses were used to examine whether calendar year of presentation to NOAR was associated with baseline HAQ and DAS28 scores. Potential confounders included age at symptom onset, sex, rheumatoid factor, and anticyclic citrullinated peptide antibody positivity.Results.A total of 1724 patients met the ACR/EULAR 2010 RA criteria at baseline. Unadjusted mean DAS28 scores decreased over time. Calendar year of presentation to NOAR was significantly associated with lower DAS28 scores over time [Y = 4.51 + (–0.56 × year) + (0.44 × year2)]. Although unadjusted median HAQ scores increased over time, calendar year of presentation to NOAR was not significantly associated with HAQ scores [Y = (1.1) + (0.023 × year) + (0.05 × year2)]. Similar results were observed in each subpopulation of patients.Conclusion.While baseline disease activity has lessened slightly over time, there has been no improvement in baseline levels of functional disability.

scholarly journals FRI0031 OBSERVATIONS ON BIOMARKERS IN VERY EARLY RHEUMATOID ARTHRITIS CONSECUTIVELY RECRUITED OVER 20 YEARS, FROM BASELINE PRESENTATION TO FIVE-YEAR OUTCOMES

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 588.2-589
Author(s):  
N. Carrier ◽  
S. Roux ◽  
A. Masetto ◽  
A. J. Debrum Fernandes ◽  
P. Liang ◽  
...  
Keyword(s):  
Disease Activity ◽  
Activity Levels ◽  
Erosive Disease ◽  
Clinical Nurse ◽  
Recent Onset ◽  
Cardiovascular Comorbidities ◽  
Remission Rates ◽  
The Impact ◽  
Over Time

Background:Since July 1998, the Early Undifferentiated PolyArthritis (EUPA) cohort recruited consecutive adults with recent-onset immune-mediated polyarthritis1,2. Patients were treated aiming at 0 swollen joint.Objectives:To analyze the impact of biomarkers over 20 years on baseline variables, treatments, comorbidities and outcomes over the first 5 years of follow up.Methods:Variables and Outcomes were collected over 5 years in consecutive patients fulfilling RA criteria, grouped according to date of inclusion (Period 1: 1998-2004; Period 2: 2005-2010; Period 3: 2011-2018). Comparisons of baseline characteristics, treatment, and outcomes over 5 years between the 3 Periods were previously presented (ACR 2018 and 2019). Erosive damage was scored according to Sharp/van der Heijde; erosive status was defined as ≥5 Erosion units. We now present observed associations between the presence of baseline prognostic biomarkers (anti-CCP2 (ACPA), RF, anti-Sa, and erosive status) with concomitant and subsequent disease activity levels, radiographic scores, comorbidities and impact of treatment. False discovery rate correction was used to adjust p-values for multiple comparisons.Results:753 patients were included: 247, 263 and 243 in Periods 1, 2 and 3, respectively. Variables at baseline. No biomarkers, including erosive status, were associated with demographics or disease activity. Erosive disease was more prevalent in ACPA+ (19.9% vs 13.9%, p=0.0417). Current smoking decreased by period (20.6, 17.2, 8.6%; p=0.02) in ACPA negatives only, remaining stable among ACPA+ (25.3, 20.9, 18.8%, NS). All comorbidities were significantly more present in ACPA negatives vs positives (RR between 1.55 and 1.99). Prevalence of cardiovascular (CV; 44.8, 55.0, 60.0%; p=0.036) and cancer (4.1, 7.1, 13.1%; p=0.02) comorbidities increased over time in ACPA negatives and remained stable in ACPA+ (CV: 33.0, 30.8, 40.7, NS; cancer: 3.0, 4.4, 6.2, NS). RF positivity decreased by period (47.8, 36.9, 36.7%, p=0.03), but ACPA+ remained stable (40.8, 35, 35.4% NS).Outcomes over 5 years of follow up.There was no link between the presence of any biomarker and subsequent disease activity scores. Positive ACPA, RF and anti-Sa at baseline predicted development of more erosive status (RR = 1.50; 1.37 and 1.52, all p<0.001). 68% reached DAS28 remission overall (70.3% in ACPA negatives, 65.2% in ACPA+). Independent of ACPA status, remission rates increased between Periods 1 vs 2 (RR = 1.14, p=0.04) and 1 vs 3 (RR=1.13, p=0.055), but not between 2 vs 3. CV comorbidities among ACPA+ increased significantly more over time vs ACPA negatives (+8.9% vs +4.1%; RR = 1.18, p=0.03). Erosion scores increased significantly more in ACPA+ treated with DMARDs only vs receiving a biologic (ΔSharp: 3.98 vs 3.11, p= 0.026; ΔErosions: 2.58 vs 1.83, p= 0.02). By period, erosive status decreased significantly (Periods 2 vs 1: RR= 0.65, p=0.002; 3 vs 1: RR=0.42, p=0.002; 3 vs 2: RR=0.64, p=0.007), both in ACPA+ and negatives.Conclusion:In this cohort of recent onset RA recruited over 20 years, we observed a constant drift towards RF-negative arthritis at baseline with decreasing smoking rates and increasing comorbidities in seronegative patients. Positive antibodies were associated more cardiovascular comorbidities accrual. Autoantibody positive (especially ACPA+) patients developed more erosive disease and had better erosion outcomes with biologic treatments. Irrespective of the presence or absence of biomarkers, marked improvements in control of disease activity and in remission rates occured over each period.References:[1]Boire G, et al.Arthritis Res Ther2005;7:R592-R603;[2]Carrier N, et al. Arthritis Res Ther2016;18:37Disclosure of Interests:Nathalie Carrier: None declared, Sophie Roux: None declared, Ariel Masetto: None declared, Artur J. deBrum Fernandes: None declared, Patrick Liang: None declared, Meryem Maoui Employee of: Bristol Myers Squibb Canada, Gilles Boire Grant/research support from: Merck Canada (Registry of biologices, Improvement of comorbidity surveillance)Amgen Canada (CATCH, clinical nurse)Abbvie (CATCH, clinical nurse)Pfizer (CATCH, Registry of biologics, Clinical nurse)Hoffman-LaRoche (CATCH)UCB Canada (CATCH, Clinical nurse)BMS (CATCH, Clinical nurse, Observational Study Protocol IM101664. SEROPOSITIVITY IN A LARGE CANADIAN OBSERVATIONAL COHORT)Janssen (CATCH)Celgene (Clinical nurse)Eli Lilly (Registry of biologics, Clinical nurse), Consultant of: Eli Lilly, Janssen, Novartis, Pfizer, Speakers bureau: Merck, BMS, Pfizer

Predicting costs over time using Bayesian Markov chain Monte Carlo methods: an application to early inflammatory polyarthritis

2006 ◽  
Vol 16 (1) ◽  
pp. 37-56 ◽  
Author(s):  
Nicola J. Cooper ◽  
Paul C. Lambert ◽  
Keith R. Abrams ◽  
Alexander J. Sutton
Keyword(s):  
Monte Carlo ◽  
Markov Chain ◽  
Markov Chain Monte Carlo ◽  
Monte Carlo Methods ◽  
Inflammatory Polyarthritis ◽  
Over Time

scholarly journals The Need for SPACE to Plan the Future for Spondyloarthritis

2021 ◽  
pp. jrheum.211212
Author(s):  
Mark Hwang ◽  
Michael H. Weisman
Keyword(s):  
Alcohol Consumption ◽  
Natural History ◽  
Disease Activity ◽  
Axial Spondyloarthritis ◽  
Lifestyle Factors ◽  
Recent Onset ◽  
The Future ◽  
History Of ◽  
Over Time

"Lifestyle Factors and Disease Activity Over Time in Early Axial Spondyloarthritis: The SPondyloArthritis Caught Early (SPACE) Cohort" by Exarchou et al aimed at looking at the importance of baseline lifestyle factors of BMI, smoking, and alcohol consumption (AC) on disease activity in recent-onset axial spondyloarthritis (axSpA).1 Does this study add to our knowledge of the natural history of axSpA?

scholarly journals Longitudinal Analysis of Anti-cardiolipin and Anti-β2-glycoprotein-I Antibodies in Recent-Onset Systemic Lupus Erythematosus: A Prospective Study in Swedish Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Martina Frodlund ◽  
Tomas Walhelm ◽  
Charlotte Dahle ◽  
Christopher Sjöwall
Keyword(s):  
Prospective Study ◽  
Lupus Erythematosus ◽  
Statistical Significance ◽  
Systemic Lupus ◽  
Clinical Value ◽  
Vascular Events ◽  
Recent Onset ◽  
Glycoprotein I ◽  
A Prospective Study ◽  
Over Time

Background: Anti-phospholipid syndrome (APS) and systemic lupus erythematous (SLE) are autoimmune disorders that often co-occur. Anti-phospholipid antibodies (aPL) are typical of both conditions and may be associated with vascular events and pregnancy-related morbidities. Whereas, aPL-screening is mandatory for individuals with suspected SLE, the clinical value of longitudinal aPL analyses in established SLE is unclear.Methods: We investigated the occurrence and variation of IgG/IgA/IgM anti-cardiolipin (aCL) and anti-β2-glycoprotein-I (anti-β2GPI) antibodies, using both the manufacturer's cut-off and a cut-off based on the 99th percentile of 400 apparently healthy donors, in recent-onset SLE. Furthermore, we evaluated the relationships between aPL levels and SLE/APS manifestations, as well as the pharmacotherapy. Patients with SLE who met validated classification criteria were included in this prospective study (N = 54). Samples were obtained at 0, 6, 12, 24, 36, 48, 60, 72, 84, and 96 months after SLE diagnosis.Results: Depending on the cut-off applied, 61.1 or 44.4% showed a positive result for at least one aPL isotype or the lupus anticoagulant test over time. Median values for all six aPL isotypes numerically decreased from inclusion to last follow-up, but none of the isotypes met statistical significance. Seroconversion (from positive to negative, or the opposite direction) was occasionally seen for both aCL and anti-β2GPI. IgA and IgM anti-β2GPI were the most common isotypes, followed by IgM aCL. Presence of IgG aCL associated significantly with myocardial infarction and miscarriage, and IgG/IgA anti-β2GPI with miscarriage.Conclusion: aPL were common during the first years of SLE. Even though the levels fluctuated over time, the patients tended to remain aPL positive or negative. Repeated aPL testing in the absence of new symptoms seems to be of uncertain value in patients with recent-onset SLE.

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