scholarly journals MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology

2021 ◽  
Author(s):  
Chihiro Sato ◽  
Nipun Mallipeddi ◽  
Nupur Ghoshal ◽  
Brenton A. Wright ◽  
Gregory S. Day ◽  
...  
Keyword(s):  
Amyloid Pathology

scholarly journals Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Yingxi Wu ◽  
Haijian Wu ◽  
Jianxiong Zeng ◽  
Brock Pluimer ◽  
Shirley Dong ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Vascular Connection ◽  
Microvascular Injury ◽  
Amyloid Pathology ◽  
Blood Flow Reduction ◽  
5Xfad Mouse ◽  
Time Courses ◽  
5Xfad Mice ◽  
Pericyte Loss

Abstract Introduction Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological cascade after TBI. However, the vascular connection between TBI and subsequent AD pathogenesis remains underexplored. Methods In a closed-head mild TBI (mTBI) model in mice with controlled cortical impact, we examined the time courses of microvascular injury, blood–brain barrier (BBB) dysfunction, gliosis and motor function impairment in wild type C57BL/6 mice. We also evaluated the BBB integrity, amyloid pathology as well as cognitive functions after mTBI in the 5xFAD mouse model of AD. Results mTBI induced microvascular injury with BBB breakdown, pericyte loss, basement membrane alteration and cerebral blood flow reduction in mice, in which BBB breakdown preceded gliosis. More importantly, mTBI accelerated BBB leakage, amyloid pathology and cognitive impairment in the 5xFAD mice. Discussion Our data demonstrated that microvascular injury plays a key role in the pathogenesis of AD after mTBI. Therefore, restoring vascular functions might be beneficial for patients with mTBI, and potentially reduce the risk of developing AD.

scholarly journals Supplementation with ribonucleotide-based ingredient (Ribodiet®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer

2021 ◽  
Vol 139 ◽  
pp. 111579
Author(s):  
Anella Saviano ◽  
Gian Marco Casillo ◽  
Federica Raucci ◽  
Alessia Pernice ◽  
Cristina Santarcangelo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Murine Model ◽  
Brain Inflammation ◽  
Amyloid Pathology

scholarly journals Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease

Aging Cell ◽  
2021 ◽  
Vol 20 (3) ◽  
Author(s):  
Jiangong Wang ◽  
Bin Liu ◽  
Yong Xu ◽  
Meizi Yang ◽  
Chaoyun Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Pathology ◽  
Β Amyloid

scholarly journals Subjective cognitive complaints at age 70: associations with amyloid and mental health

2021 ◽  
pp. jnnp-2020-325620
Author(s):  
Ivanna M. Pavisic ◽  
Kirsty Lu ◽  
Sarah E. Keuss ◽  
Sarah-Naomi James ◽  
Christopher A. Lane ◽  
...  
Keyword(s):  
Family History ◽  
Trait Anxiety ◽  
Population Based ◽  
Cross Sectional Study ◽  
Subjective Cognitive Decline ◽  
Cross Sectional ◽  
Amyloid Pathology ◽  
History Of ◽  
Β Amyloid ◽  
Anxiety Depression

ObjectiveTo investigate subjective cognitive decline (SCD) in relation to β-amyloid pathology and to test for associations with anxiety, depression, objective cognition and family history of dementia in the Insight 46 study.MethodsCognitively unimpaired ~70-year-old participants, all born in the same week in 1946 (n=460, 49% female, 18% amyloid-positive), underwent assessments including the SCD-Questionnaire (MyCog). MyCog scores were evaluated with respect to 18F-Florbetapir-PET amyloid status (positive/negative). Associations with anxiety, depression, objective cognition (measured by the Preclinical Alzheimer Cognitive Composite, PACC) and family history of dementia were also investigated. The informant’s perspective on SCD was evaluated in relation to MyCog score.ResultsAnxiety (mean (SD) trait anxiety score: 4.4 (3.9)) was associated with higher MyCog scores, especially in women. MyCog scores were higher in amyloid-positive compared with amyloid-negative individuals (adjusted means (95% CIs): 5.3 (4.4 to 6.1) vs 4.3 (3.9 to 4.7), p=0.044), after accounting for differences in anxiety. PACC (mean (SD) −0.05 (0.68)) and family history of dementia (prevalence: 23.9%) were not independently associated with MyCog scores. The informant’s perception of SCD was generally in accordance with that of the participant.ConclusionsThis cross-sectional study demonstrates that symptoms of SCD are associated with both β-amyloid pathology, and more consistently, trait anxiety in a population-based cohort of older adults, at an age when those who are destined to develop dementia are still likely to be some years away from symptoms. This highlights the necessity of considering anxiety symptoms when assessing Alzheimer’s disease pathology and SCD.

P1-326: Role of neuroinflammation in hypertension-induced brain amyloid pathology

2010 ◽  
Vol 6 ◽  
pp. S268-S268
Author(s):  
Daniela Carnevale ◽  
Giada Mascio ◽  
Germana Cocozza ◽  
Giuseppe Cifelli ◽  
Luisa Minghetti ◽  
...  
Keyword(s):  
Amyloid Pathology

scholarly journals Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer’s Disease

2016 ◽  
Vol 68 (22) ◽  
pp. 2395-2407 ◽  
Author(s):  
Luca Troncone ◽  
Marco Luciani ◽  
Matthew Coggins ◽  
Elissa H. Wilker ◽  
Cheng-Ying Ho ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Pathology ◽  
Aβ Amyloid

scholarly journals Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Junjun Liu ◽  
Shuyu Liu ◽  
Yukino Matsumoto ◽  
Saki Murakami ◽  
Yusuke Sugakawa ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Amyloid Pathology ◽  
Β Protein ◽  
Angiotensin Type
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