scholarly journals Recurrent seizure‐related GRIN1 variant: Molecular mechanism and targeted therapy

2021 ◽  
Author(s):  
Yuchen Xu ◽  
Rui Song ◽  
Wenjuan Chen ◽  
Katie Strong ◽  
Daniel Shrey ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Molecular Mechanism ◽  
Recurrent Seizure

scholarly journals Applications of Multi-omics Approaches for Exploring the Molecular Mechanism of Ovarian Carcinogenesis

2021 ◽  
Vol 11 ◽  
Author(s):  
Miaomiao Ye ◽  
Yibin Lin ◽  
Shuya Pan ◽  
Zhi-wei Wang ◽  
Xueqiong Zhu
Keyword(s):  
Ovarian Cancer ◽  
Targeted Therapy ◽  
Cancer Patients ◽  
Molecular Mechanism ◽  
Molecular Mechanisms ◽  
Prognostic Biomarkers ◽  
Molecular Signatures ◽  
Common Cause ◽  
Ovarian Carcinogenesis ◽  
Therapy Strategies

Ovarian cancer ranks as the fifth most common cause of cancer-related death in females. The molecular mechanisms of ovarian carcinogenesis need to be explored in order to identify effective clinical therapies for ovarian cancer. Recently, multi-omics approaches have been applied to determine the mechanisms of ovarian oncogenesis at genomics (DNA), transcriptomics (RNA), proteomics (proteins), and metabolomics (metabolites) levels. Multi-omics approaches can identify some diagnostic and prognostic biomarkers and therapeutic targets for ovarian cancer, and these molecular signatures are beneficial for clarifying the development and progression of ovarian cancer. Moreover, the discovery of molecular signatures and targeted therapy strategies could noticeably improve the prognosis of ovarian cancer patients.

scholarly journals Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy

2021 ◽  
Author(s):  
Tien‐Fen Kuo ◽  
Shuo‐Wen Hsu ◽  
Shou‐Hsien Huang ◽  
Cicero Lee‐Tian Chang ◽  
Ching‐Shan Feng ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Molecular Mechanism ◽  
Β Cell

scholarly journals m6A modification in RNA: biogenesis, functions and roles in gliomas

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Yuhao Zhang ◽  
Xiuchao Geng ◽  
Qiang Li ◽  
Jianglong Xu ◽  
Yanli Tan ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Early Diagnosis ◽  
Molecular Mechanism ◽  
Nuclear Export ◽  
Malignant Tumour ◽  
Research Progress ◽  
Rna Modification ◽  
Regulation Mechanism ◽  
Treatment Measures ◽  
The Central Nervous System

Abstract The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA sequencing, the relevant molecular mechanism of m6A modification has gradually been revealed. It has been found that the effect of m6A modification on RNA metabolism involves processing, nuclear export, translation and even decay. As the most common malignant tumour of the central nervous system, gliomas (especially glioblastoma) have a very poor prognosis, and treatment efficacy is not ideal even with the application of high-intensity treatment measures of surgery combined with chemoradiotherapy. Exploring the origin and development mechanisms of tumour cells from the perspective of tumour biogenesis has always been a hotspot in the field of glioma research. Emerging evidence suggests that m6A modification can play a key role in gliomas through a variety of mechanisms, providing more possibilities for early diagnosis and targeted therapy of gliomas. The aim of the present review is to focus on the research progress regarding the association between m6A modification and gliomas. And to provide a theoretical basis according to the currently available literature for further exploring this association. This review may provide new insights for the molecular mechanism, early diagnosis, histologic grading, targeted therapy and prognostic evaluation of gliomas.

Additional evidence for AQP1 vesicle trafficking as a molecular mechanism for ductal bile secretion

2001 ◽  
Vol 120 (5) ◽  
pp. A91-A91
Author(s):  
P TIETZ ◽  
P SPLINTER ◽  
M MCNIVEN ◽  
R HUEBERT ◽  
N LARUSSO
Keyword(s):  
Molecular Mechanism ◽  
Vesicle Trafficking ◽  
Bile Secretion
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