scholarly journals Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature

2021 ◽  
Author(s):  
Rebekah M. Ahmed ◽  
Nga Yan Tse ◽  
Yu Chen ◽  
Elana Henning ◽  
John R. Hodges ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Neural Correlates ◽  
Fat Preference

Different apathy clinical profile and neural correlates in behavioral variant frontotemporal dementia and Alzheimer's disease

2017 ◽  
Vol 33 (1) ◽  
pp. 141-150 ◽  
Author(s):  
Marta Fernández-Matarrubia ◽  
Jordi A. Matías-Guiu ◽  
María Nieves Cabrera-Martín ◽  
Teresa Moreno-Ramos ◽  
María Valles-Salgado ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Neural Correlates ◽  
Clinical Profile ◽  
Behavioral Variant Frontotemporal Dementia

Shared neural correlates of limb apraxia in early stages of Alzheimer's dementia and behavioural variant frontotemporal dementia

Cortex ◽  
2016 ◽  
Vol 84 ◽  
pp. 1-14 ◽  
Author(s):  
Andreas Johnen ◽  
Lisa Brandstetter ◽  
Christian Kärgel ◽  
Heinz Wiendl ◽  
Hubertus Lohmann ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Neural Correlates ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
Early Stages ◽  
Limb Apraxia

scholarly journals Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates

Neurology ◽  
2008 ◽  
Vol 71 (10) ◽  
pp. 736-742 ◽  
Author(s):  
G. Zamboni ◽  
E. D. Huey ◽  
F. Krueger ◽  
P. F. Nichelli ◽  
J. Grafman
Keyword(s):  
Frontotemporal Dementia ◽  
Neural Correlates

scholarly journals Functional neural correlates of emotional expression processing deficits in behavioural variant frontotemporal dementia

2013 ◽  
Vol 38 (3) ◽  
pp. 174-182 ◽  
Author(s):  
Karim Virani ◽  
Sarah Jesso ◽  
Andrew Kertesz ◽  
Derek Mitchell ◽  
Elizabeth Finger
Keyword(s):  
Frontotemporal Dementia ◽  
Emotional Expression ◽  
Neural Correlates ◽  
Processing Deficits ◽  
Expression Processing

Neural Correlates of Activities of Daily Living in Frontotemporal Dementia

2013 ◽  
Vol 26 (1) ◽  
pp. 51-57 ◽  
Author(s):  
E. Mioshi ◽  
J. R. Hodges ◽  
M. Hornberger
Keyword(s):  
Activities Of Daily Living ◽  
Frontotemporal Dementia ◽  
Gray Matter ◽  
Daily Living ◽  
Functional Disability ◽  
Neural Correlates ◽  
Voxel Based Morphometry ◽  
Tailored Interventions ◽  
Gray Matter Atrophy ◽  
Patient Groups

Background: Little research to date has investigated neural correlates of functional disability in frontotemporal dementia (FTD). Methods: Activities of daily living (ADL) were covaried against gray matter atrophy regions via Voxel-based morphometry in FTD (n = 52) and contrasted against a dementia control Alzheimer disease (AD) group (n = 20) and healthy age-matched controls (n = 18). Results: Both patient groups had similar ADL scores. However, FTD and AD differed on the gray matter atrophy areas associated with ADL scores. The FTD showed involvement of prefrontal and thalamus regions while AD showed widespread temporal, parietal, frontal, and caudate atrophy correlating with ADL dysfunction. Importantly, only the left superior frontal gyrus was implicated in ADL dysfunction for both FTD and AD. Conclusions: Differences in underlying neural correlates of ADL impairment have important clinical implications as these differences should be taken into account when interventions are planned. Dementia subtypes might require specifically tailored interventions for functional disability.

scholarly journals Uncovering the prevalence and neural substrates of anhedonia in frontotemporal dementia

Brain ◽  
2021 ◽  
Author(s):  
Siobhán R Shaw ◽  
Hashim El-Omar ◽  
Daniel Roquet ◽  
John R Hodges ◽  
Olivier Piguet ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Small Region ◽  
Neural Correlates ◽  
Brain Regions ◽  
Semantic Dementia ◽  
Voxel Based Morphometry ◽  
Targeted Interventions ◽  
The Impact

Abstract Much of human behaviour is motivated by the drive to experience pleasure. The capacity to envisage pleasurable outcomes and to engage in goal-directed behaviour to secure these outcomes depends upon the integrity of frontostriatal circuits in the brain. Anhedonia refers to the diminished ability to experience, and to pursue, pleasurable outcomes, and represents a prominent motivational disturbance in neuropsychiatric disorders. Despite increasing evidence of motivational disturbances in frontotemporal dementia (FTD), no study to date has explored the hedonic experience in these syndromes. Here, we present the first study to document the prevalence and neural correlates of anhedonia in FTD in comparison with Alzheimer’s disease, and its potential overlap with related motivational symptoms including apathy and depression. A total of 172 participants were recruited, including 87 FTD, 34 Alzheimer’s disease, and 51 healthy older control participants. Within the FTD group, 55 cases were diagnosed with clinically probable behavioural variant FTD, 24 presented with semantic dementia, and eight cases had progressive non-fluent aphasia (PNFA). Premorbid and current anhedonia was measured using the Snaith-Hamilton Pleasure Scale, while apathy was assessed using the Dimensional Apathy Scale, and depression was indexed via the Depression, Anxiety and Stress Scale. Whole-brain voxel-based morphometry analysis was used to examine associations between grey matter atrophy and levels of anhedonia, apathy, and depression in patients. Relative to controls, behavioural variant FTD and semantic dementia, but not PNFA or Alzheimer’s disease, patients showed clinically significant anhedonia, representing a clear departure from pre-morbid levels. Voxel-based morphometry analyses revealed that anhedonia was associated with atrophy in an extended frontostriatal network including orbitofrontal and medial prefrontal, paracingulate and insular cortices, as well as the putamen. Although correlated on the behavioural level, the neural correlates of anhedonia were largely dissociable from that of apathy, with only a small region of overlap detected in the right orbitofrontal cortices whilst no overlapping regions were found between anhedonia and depression. This is the first study, to our knowledge, to demonstrate profound anhedonia in FTD syndromes, reflecting atrophy of predominantly frontostriatal brain regions specialized for hedonic tone. Our findings point to the importance of considering anhedonia as a primary presenting feature of behavioural variant FTD and semantic dementia, with distinct neural drivers to that of apathy or depression. Future studies will be essential to address the impact of anhedonia on everyday activities, and to inform the development of targeted interventions to improve quality of life in patients and their families.

scholarly journals The neural correlates and clinical characteristics of psychosis in the frontotemporal dementia continuum and the C9orf72 expansion

2017 ◽  
Vol 13 ◽  
pp. 439-445 ◽  
Author(s):  
Emma M Devenney ◽  
Ramon Landin-Romero ◽  
Muireann Irish ◽  
Michael Hornberger ◽  
Eneida Mioshi ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Clinical Characteristics ◽  
Neural Correlates ◽  
C9orf72 Expansion

scholarly journals Neural correlates of behavioural symptoms in behavioural variant frontotemporal dementia and Alzheimer's disease: Employment of a visual MRI rating scale

2012 ◽  
Vol 6 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Christopher Go ◽  
Eneida Mioshi ◽  
Belinda Yew ◽  
John R. Hodges ◽  
Michael Hornberger
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prefrontal Cortex ◽  
Frontotemporal Dementia ◽  
Rating Scale ◽  
Neural Correlates ◽  
Orbital Frontal Cortex ◽  
Behavioural Symptoms ◽  
Frontal System ◽  
System Behaviour

ABSTRACT Frontotemporal dementia (FTD) patients often present with severe behavioural disturbances and concomitant lack of insight. The underlying neural correlates of these disturbances are mostly attributed to prefrontal cortex dysfunction, but are still poorly understood. Objectives: The current study explores whether a simple visual magnetic resonance imaging (MRI) rating scale in combination with the Frontal System Behaviour Scale (FrSBe) can be used to identify the prefrontal correlates of behavioural symptoms in behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). Methods: Forty-eight patients with a clinical diagnosis of bvFTD and AD participated in the study. Their behavioural profiles were assessed using the Frontal System Behaviour Scale (FrSBe) and cross-correlated to the atrophy of the sub-regions in the prefrontal cortex using a 5-point visual rating scale of MRI scans. Results: Patients with bvFTD showed higher incidence of behavioural disturbances than AD with apathy being the most significant. BvFTD patients also showed the highest incidence of atrophy in the orbital frontal cortex and this atrophy was correlated with the apathetic features. Conclusions: Employment of a simple visual MRI rating scale can be used in combination with a behavioural screening test to identify reliably the behavioural symptoms in bvFTD and AD. These findings will inform the diagnostic accuracy of the neural correlates of behavioural dysfunction in bvFTD in the future.

scholarly journals Neural correlates of body composition in frontotemporal dementia

2019 ◽  
Vol 405 ◽  
pp. 39
Author(s):  
R. Ahmed ◽  
R. Landin-Romero ◽  
C. Liang ◽  
J. Keogh ◽  
E. Henning ◽  
...  
Keyword(s):  
Body Composition ◽  
Frontotemporal Dementia ◽  
Neural Correlates
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