scholarly journals Amyloid‐ β , cortical thickness, and subsequent cognitive decline in cognitively normal oldest‐old

2021 ◽  
Vol 8 (2) ◽  
pp. 348-358
Author(s):  
Wiesje Pelkmans ◽  
Nienke Legdeur ◽  
Mara Kate ◽  
Frederik Barkhof ◽  
Maqsood M. Yaqub ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Cortical Thickness ◽  
Oldest Old ◽  
Amyloid Β ◽  
Cognitively Normal

scholarly journals The effect of amyloid β on cognitive decline is modulated by neural integrity in cognitively normal elderly

2013 ◽  
Vol 9 (6) ◽  
pp. 687-698.e1 ◽  
Author(s):  
Miranka Wirth ◽  
Hwamee Oh ◽  
Elizabeth C. Mormino ◽  
Candace Markley ◽  
Susan M. Landau ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Amyloid Β ◽  
Cognitively Normal

scholarly journals Amyloid‐β deposition in cognitively normal oldest‐old is associated with cortical thinning and faster memory decline

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Wiesje Pelkmans ◽  
Nienke Legdeur ◽  
Mara ten Kate ◽  
Maqsood Yaqub ◽  
Frederik Barkhof ◽  
...  
Keyword(s):  
Oldest Old ◽  
Amyloid Β ◽  
Memory Decline ◽  
Cognitively Normal ◽  
Cortical Thinning

scholarly journals Non‐linear relationship between plasma amyloid‐β 40 level and cognitive decline in a cognitively normal population

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Fan Gao ◽  
Suhang Shang ◽  
Chen Chen ◽  
Liangjun Dang ◽  
Ling Gao ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Linear Relationship ◽  
Normal Population ◽  
Amyloid Β ◽  
Cognitively Normal ◽  
Non Linear

scholarly journals Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults

2019 ◽  
Vol 27 (11) ◽  
pp. 1247-1256 ◽  
Author(s):  
Kelsey D. Biddle ◽  
Federico d'Oleire Uquillas ◽  
Heidi I.L. Jacobs ◽  
Benjamin Zide ◽  
Dylan R. Kirn ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Social Engagement ◽  
Amyloid Β ◽  
Cognitively Normal

CONTINUOUS MEASURES OF β-AMYLOIDOSIS AND CORTICAL THICKNESS IN RELATION TO COGNITIVE DECLINE IN COGNITIVELY NORMAL INDIVIDUALS: A POPULATION-BASED STUDY

2017 ◽  
Vol 13 (7) ◽  
pp. P223-P224
Author(s):  
David S. Knopman ◽  
Clifford R. Jack ◽  
Emily S. Lundt ◽  
Stephen D. Weigand ◽  
Prashanthi Vemuri ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Cortical Thickness ◽  
Population Based ◽  
Population Based Study ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
Continuous Measures

scholarly journals Amyloid β Deposition and Suspected Non-Alzheimer Pathophysiology and Cognitive Decline Patterns for 12 Years in Oldest Old Participants Without Dementia

2018 ◽  
Vol 75 (1) ◽  
pp. 88 ◽  
Author(s):  
Yujing Zhao ◽  
Dana L. Tudorascu ◽  
Oscar L. Lopez ◽  
Ann D. Cohen ◽  
Chester A. Mathis ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Oldest Old ◽  
Amyloid Β

scholarly journals SPON1 Is Associated with Amyloid-β and APOE ε4-Related Cognitive Decline in Cognitively Normal Adults

2021 ◽  
Vol 5 (1) ◽  
pp. 111-120
Author(s):  
Shane Fernandez ◽  
Samantha C. Burnham ◽  
Lidija Milicic ◽  
Greg Savage ◽  
Paul Maruff ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Amyloid Β ◽  
Independent Effect ◽  
Imaging Biomarkers ◽  
Cognitively Normal ◽  
Study Results ◽  
Global Cognition ◽  
Mixed Modelling ◽  
Normal Adults

Abstract. Background: Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer’s disease. Objective: The aim of this study was to assess whether the association was present in cognitively normal older adults. Methods: Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study. Results: No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE) ɛ4 and rs11023139 in individuals with high amyloid-β burden. APOE ɛ4/rs11023139-A carriers declined significantly faster than APOE ɛ4/rs11023139-G_G carriers in measures of global cognition (p = 0.011) and verbal episodic memory (p = 0.020). Conclusion: These results suggest that carriage of the Spondin-1 rs11023139-A allele significantly contributes to a worsening of cognitive performance in APOE ɛ4 cognitively normal older adults with a high neocortical amyloid-β burden.

scholarly journals P3-398: AMYLOID-β IS ASSOCIATED WITH THINNER CORTEX IN COGNITIVELY NORMAL OLDEST-OLD INDIVIDUALS

2019 ◽  
Vol 15 ◽  
pp. P1104-P1105
Author(s):  
Wiesje Pelkmans ◽  
Nienke Legdeur ◽  
Mara ten Kate ◽  
Maqsood M. Yaqub ◽  
Bart N.M. Van Berckel ◽  
...  
Keyword(s):  
Oldest Old ◽  
Amyloid Β ◽  
Cognitively Normal

scholarly journals P3-305: SYNERGISTIC ADVERSE EFFECTS OF WIDOWHOOD AND AMYLOID-β ON COGNITIVE DECLINE IN COGNITIVELY NORMAL OLDER ADULTS

2019 ◽  
Vol 15 ◽  
pp. P1054-P1054
Author(s):  
Kelsey D. Biddle ◽  
Federico d'Oleire Uquillas ◽  
Benjamin Zide ◽  
Dylan Kirn ◽  
Heidi IL. Jacobs ◽  
...  
Keyword(s):  
Older Adults ◽  
Adverse Effects ◽  
Cognitive Decline ◽  
Amyloid Β ◽  
Cognitively Normal
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