CSF SerpinA1 in Creutzfeldt–Jakob disease and frontotemporal lobar degeneration

Samir Abu‐Rumeileh; Steffen Halbgebauer; Petra Steinacker; Sarah Anderl‐Straub; Barbara Polischi; Albert C. Ludolph; Sabina Capellari; Piero Parchi; Markus Otto

doi:10.1002/acn3.50980

CSF SerpinA1 in Creutzfeldt–Jakob disease and frontotemporal lobar degeneration

Annals of Clinical and Translational Neurology ◽

10.1002/acn3.50980 ◽

2020 ◽

Vol 7 (2) ◽

pp. 191-199 ◽

Cited By ~ 3

Author(s):

Samir Abu‐Rumeileh ◽

Steffen Halbgebauer ◽

Petra Steinacker ◽

Sarah Anderl‐Straub ◽

Barbara Polischi ◽

...

Keyword(s):

Frontotemporal Lobar Degeneration ◽

Jakob Disease

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Co‐incidental C9orf72 expansion mutation‐related frontotemporal lobar degeneration pathology and sporadic Creutzfeldt−Jakob disease

European Journal of Neurology ◽

10.1111/ene.14621 ◽

2020 ◽

Author(s):

Sigrid Klotz ◽

Theresa König ◽

Marcus Erdler ◽

Andreas Ulram ◽

Anita Nguyen ◽

...

Keyword(s):

Frontotemporal Lobar Degeneration ◽

C9orf72 Expansion ◽

Jakob Disease ◽

Expansion Mutation

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Frontotemporal Lobar Degeneration: Characterizing Semantic Binding and Abstracted Meaning Abilities

Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders ◽

10.1044/nnsld19.4.117 ◽

2009 ◽

Vol 19 (4) ◽

pp. 117-125 ◽

Cited By ~ 1

Author(s):

Raksha Anand ◽

John Hart ◽

Patricia S. Moore ◽

Sandra B. Chapman

Keyword(s):

Frontotemporal Lobar Degeneration ◽

Assessment Tools ◽

Progressive Decline ◽

Cognitively Normal ◽

Nonfluent Aphasia ◽

Traditional Assessment ◽

Language Measures ◽

Semantic Object ◽

Semantic Problem ◽

Progressive Nonfluent Aphasia

Abstract Purpose: Frontotemporal lobar degeneration (FTLD) encompasses a group of neurodegenerative disorders characterized by gradual and progressive decline in behavior and/or language. Identifying the subtypes of FTLD can be challenging with traditional assessment tools. Growing empirical evidence suggests that language measures might be useful in differentiating FTLD subtypes. Method: In this paper, we examined the performance of five individuals with FTLD (two with frontotemporal dementia, two with semantic dementia, and one with progressive nonfluent aphasia) and 10 cognitively normal older adults on measures of semantic binding (Semantic Object Retrieval Test and semantic problem solving) and abstracted meaning (generation of interpretive statement and proverb interpretation). Results and Conclusion: A differential profile of impairment was observed in the three FTLD subtypes on these four measures. Further examination of these measures in larger groups will establish their clinical utility in differentiating the FTLD subtypes.

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