scholarly journals 4DCT and VMAT for lung patients with irregular breathing

Author(s):  
Rhydian Caines ◽  
Naomi K. Sisson ◽  
Carl G. Rowbottom
Keyword(s):  
2012 ◽  
Vol 32 (23) ◽  
pp. 7895-7906 ◽  
Author(s):  
S. A. Crone ◽  
J.-C. Viemari ◽  
S. Droho ◽  
A. Mrejeru ◽  
J.-M. Ramirez ◽  
...  

1986 ◽  
Vol 60 (6) ◽  
pp. 2123-2127 ◽  
Author(s):  
L. Y. Lee ◽  
R. F. Morton ◽  
M. J. McIntosh ◽  
J. A. Turbek

The purpose of this study was to develop an isolated upper airway preparation in conscious dogs. Each of the four dogs was trained to wear an individually fitted respiratory mask and surgically prepared with two side-hole tracheostomies. After full recovery, one endotracheal tube was inserted caudally into the lower tracheostomy hole and another tube cranially into the upper tracheostomy. When the two endotracheal tubes were connected to a breathing circuit including a box-balloon system, the magnitude and pattern of the inspiratory flow through the upper airway were identical to that inhaled spontaneously into the lungs by the dogs, but the gas medium inhaled into the upper airway could be independently controlled. Thus it allowed test gas mixtures to be inhaled spontaneously through an isolated upper airway. One limitation was that the inspired gas remained in the upper airway during expiration, but this can be corrected by a simple modification of the breathing circuit. This preparation was tested in studying the respiratory effects of upper airway exposure to CO2 gas mixtures. Our results showed small but significant reduction in both rate and volume of respiration when the concentration of CO2 gas mixture inhaled through the upper airway exceeded 5%. Irregular breathing patterns were frequently elicited in these dogs by higher concentrations (greater than 12%) of CO2.


2019 ◽  
Vol 597 (24) ◽  
pp. 5799-5820 ◽  
Author(s):  
Camilo Toledo ◽  
David C. Andrade ◽  
Hugo S. Díaz ◽  
Katherin V. Pereyra ◽  
Karla G. Schwarz ◽  
...  

2018 ◽  
Vol 52 (5) ◽  
pp. 515-525 ◽  
Author(s):  
Avishag Tuval ◽  
Liora Las ◽  
Yael Shilo-Benjamini

Egyptian fruit bats are increasingly used as model animals in neuroscience research. Our aim was to characterize suitable injectable anaesthesia for this species, possibly replacing inhalant anaesthesia, thus minimizing occupational health hazards. Eight bats were randomly assigned by a crossover design for subcutaneously administered combinations of medetomidine-midazolam with: saline (MM-Sal), ketamine (MM-Ket), fentanyl (MM-Fen), morphine (MM-Mor), or butorphanol (MM-But). The anaesthetic depth and vital signs were monitored at baseline and every 10 min until bats recovered. If after 180 min the bats did not recover, atipamezole was administered. Mean induction times were 7–11.5 min with all combinations. Twitching during induction was common. All combinations produced anaesthesia, with significantly decreased heart rate (from 400 to 200 bpm) and respiratory rate (from 120–140 to 36–65 rpm). Arrhythmia and irregular breathing patterns occurred. MM-Fen, MM-Mor, and MM-But depressed respiration significantly more than MM-Sal. Time to first movement with MM-Ket and MM-But lasted significantly longer than with MM-Sal. Recovery time was significantly shorter in the MM-Sal (88 min) in comparison to all other treatments, and it was significantly longer in the MM-But (159 min), with atipamezole administered to four of the eight bats. In conclusion, all five anaesthetic protocols are suitable for Egyptian fruit bats; MM-Ket produces long anaesthesia and minimal respiratory depression, but cannot be antagonized completely. MM-Fen, MM-Mor, and MM-But depress respiration, but are known to produce good analgesia, and can be fully antagonized. Administration of atipamezole following the use of MM-But in Egyptian fruit bats is recommended.


Life Sciences ◽  
1987 ◽  
Vol 41 (20) ◽  
pp. 2303-2312 ◽  
Author(s):  
Jan Hedner ◽  
Thomas Hedner

2016 ◽  
Vol 56 (3) ◽  
pp. 298-300
Author(s):  
April Edwards ◽  
Stephanie Permar ◽  
Scott Buck ◽  
Ravi Jhaveri

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