scholarly journals Algorithm for an automatic treatment planning system using a single‐arc VMAT for prostate cancer

Author(s):  
Takumi Kodama ◽  
Shigehiro Kudo ◽  
Shogo Hatanaka ◽  
Masatsugu Hariu ◽  
Munefumi Shimbo ◽  
...  
2015 ◽  
Vol 49 (3) ◽  
pp. 291-298 ◽  
Author(s):  
Christopher Amaloo ◽  
Daryl P. Nazareth ◽  
Lalith K. Kumaraswamy

Abstract Background. Volumetric modulated arc therapy (VMAT) has quickly become accepted as standard of care for the treatment of prostate cancer based on studies showing it is able to provide faster delivery with adequate target coverage and reduced monitor units while maintaining organ at risk (OAR) sparing. This study aims to demonstrate the potential to increase dose conformality with increased planner control and OAR sparing using a hybrid treatment technique compared to VMAT. Methods. Eleven patients having been previously treated for prostate cancer with VMAT techniques were replanned with a hybrid technique on Varian Treatment Planning System. Multiple static IMRT fields (2 to 3) were planned initially based on critical OAR to reduce dose but provide some planning treatment volume (PTV) coverage. This was used as a base dose plan to provide 30-35% coverage for a single arc VMAT plan. Results. The clinical VMAT plan was used as a control for the purposes of comparison. Average of all OAR sparing between the hybrid technique and VMAT showed the hybrid plan delivering less dose in almost all cases except for V80 of the bladder and maximum dose to right femoral head. PTV coverage was superior with the VMAT technique. Monitor unit differences varied, with the hybrid plan able to deliver fewer units 37% of the time, similar results 18% of the time, and higher units 45% of the time. On average, the hybrid plan delivered 10% more monitor units. Conclusions. The hybrid plan can be delivered in a single gantry rotation combining aspects of VMAT with regions of dynamic intensity modulated radiation therapy (IMRT) within the treatment arc.


2020 ◽  
Author(s):  
Pedro J. Prada ◽  
J. Cardenal ◽  
A. García Blanco ◽  
M. Ferri ◽  
E. Arrojo ◽  
...  

Abstract Background: To evaluate the reduction, the absorbed dose delivered to the neurovascular bundle (NB) in patients with localized prostate cancer treated with only HDR brachytherapy and neurovascular bundle protection with Hyaluronic acid (HA) on the side of the prostate to increase the distance from NB to the radioactive sources.Material and Methods: This is the first published report in the medical literature that study a new approach to decrease neurovascular bundle toxicity and improve quality of life for patients with prostate cancer treated with radical brachytherapy as monotherapy. Transperineal HA injection on the side of the prostate into the lateral aspect of the prostate fat was used to consistently displace several autonomic fibres and vessels the lateral wall of the prostate away from radiation sources.Results: When a protection in the form of a HA layer is placed, the reduction effect at the maximum dose is between 46% and 54% (calculated values), which means the method for protection is highly recommended. The values of the absorbed dose calculated in this project have been compared with the ones given by the treatment planning system. These calculated values are similar than the ones given by the treatment planning system (56±2).Conclusions: This newly created space decreases absorbed dose in the neurovascular bundle, calculated with the TPS and measuremed by microMOSFET due to the thickness of HA.


2018 ◽  
Vol 46 ◽  
pp. 153-159 ◽  
Author(s):  
Elena Gallio ◽  
Francesca Romana Giglioli ◽  
Andrea Girardi ◽  
Alessia Guarneri ◽  
Umberto Ricardi ◽  
...  

2018 ◽  
Vol 127 ◽  
pp. S1037-S1038
Author(s):  
R.L. Christiansen ◽  
C.R. Hansen ◽  
R.H. Dahlrot ◽  
A.S. Bertelsen ◽  
O. Hansen ◽  
...  

2017 ◽  
Author(s):  
Kurt W Van Delinder

Background: Traditionally, EBRT prostate treatments have been administered using three different techniques: three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). These radiation therapy treatment techniques are often combined with additional options focusing on treating systemic disease and the entire volume of the prostate. A novel approach to EBRT is currently in development, a localized treatment administered to only the primary disease within the prostate volume termed ‘Focal Therapy’. Methods/Design: The proposed research study is aimed to simulate 10 random EBRT prostate focal therapy treatments replicated within two treatment planning software; Monaco treatment planning system and Eclipse treatment planning system. All ten plans will be contoured simulations of focal therapy imaging sets replicated from authentic mpMRI anatomical images of focal therapy eligible prostate cancer patients. Following the completion of the 10 clinical plans, QA plans will be generated and administered via each products current commercial linacs; the TrueBeam and the Versa. All QA plans will have their radiation doses measured with Gafchromic EBT3 radiochromic film and analyzed using the gamma analysis index (γ). Discussion: To examine the uncertainties and limitations of an EBRT focal therapy prostate cancer treatment, it’s imperative that a large study replicating many clinical cases under varying conditions should be conducted. This allows the ability for the clinician to investigate errors and uncertainties at each stage of the treatment process prior to committing to a clinical study. The experimental results can also be used as a reference for the creation of a standard guideline for the administration of focal therapy as a curative treatment for prostate cancer.


2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 219-219
Author(s):  
Joseph A. Moore ◽  
Wuyang Yang ◽  
Kim Evans ◽  
Avani Satish Dholakia ◽  
Albert Koong ◽  
...  

219 Background: To clinically utilize an SQL relational database of prior treated patients to generate objectives for future treatment plans. A database approach allows for more rapid planning by starting with a better initial solution and improves safety by providing good known achievable dose values for the initial optimization. The use of a database allows for trending of dose, structure and toxicity data. Methods: A database of fifty-three patients from three institutions is populated with dose and structure data via an automatic script within the treatment planning system. For each new patient, overlap volume histograms (OVHs) are generated to describe the relationship between targets and critical structures. To aid in database consistency, a renaming interface is used which maps known alternative structure names to common names in the database. To ensure all required structures are present, the user is prompted with the names of missing structures. This interface allows selection of machine, energy and commonly used beam sets. The database is queried for all prior patients with the same or closer relationship between the target and each critical structure. The dose objectives reported are the lowest achievable dose from all patients as difficult or harder to plan as determined by OVH. Queried dose objectives are automatically loaded into the treatment planning system and optimized. A protocol quality tool is developed to quickly assess how well plans adhere to specified protocols. Results: Twenty-seven SBRT patients have been planned and clinically approved using the automatic planning tool and future patients continue to be added to the database. OVH computation required approximately 2 minutes, while typical plan optimization required 2.5 minutes. If auto-planned patients require even one fewer optimization to achieve an acceptable plan, total planning time is reduced. Safety is improved by reducing the number of protocol violations from 35% to 6% for one objective. Conclusions: Automatic treatment planning allows for rapid planning while reducing normal tissue dose to known achievable values. The continued addition of patients to the database allows for improvement of the automatically selected planning objectives.


Sign in / Sign up

Export Citation Format

Share Document