scholarly journals Dosimetric impact of simulated changes in large bowel content during proton therapy with simultaneous integrated boost for locally advanced pancreatic cancer

2021 ◽  
Author(s):  
Yuki Narita ◽  
Takahiro Kato ◽  
Kimihiro Takemasa ◽  
Hiroki Sato ◽  
Tomohiro Ikeda ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Proton Therapy ◽  
Large Bowel ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Simultaneous Integrated Boost ◽  
Locally Advanced Pancreatic Cancer ◽  
Bowel Content ◽  
Integrated Boost

scholarly journals Efficacy and feasibility of proton beam radiotherapy using the simultaneous integrated boost technique for locally advanced pancreatic cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tae Hyun Kim ◽  
Woo Jin Lee ◽  
Sang Myung Woo ◽  
Eun Sang Oh ◽  
Sang Hee Youn ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Proton Beam ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Simultaneous Integrated Boost ◽  
Locally Advanced Pancreatic Cancer ◽  
Maintenance Chemotherapy ◽  
Proton Beam Radiotherapy ◽  
Chemotherapy Group ◽  
Integrated Boost

AbstractTo evaluate the clinical efficacy and feasibility of proton beam radiotherapy (PBT) using the simultaneous integrated boost (SIB) technique in locally advanced pancreatic cancer (LAPC), 81 LAPC patients receiving PBT using SIB technique were analyzed. The prescribed doses to planning target volume (PTV)1 and PTV2 were 45 or 50 GyE and 30 GyE in 10 fractions, respectively. Of 81 patients, 18 patients received PBT without upfront and maintenance chemotherapy (group I), 44 received PBT followed by maintenance chemotherapy (group II), and 19 received PBT after upfront chemotherapy followed by maintenance chemotherapy (n = 16) (group III). The median follow-up time was 19.6 months (range 2.3–57.6 months), and the median overall survival (OS) times of all patients and of those in groups I, II, and III were 19.3 months (95% confidence interval [CI] 16.8–21.7 months), 15.3 months (95% CI 12.9–17.7 months), 18.3 months (95% CI 15.9–20.7 months), and 26.1 months (95% CI 17.8–34.3 months), respectively (p = 0.043). Acute and late grade ≥ 3 toxicities related to PBT were not observed. PBT with the SIB technique showed promising OS for LAPC patients with a safe toxicity profile, and intensive combinations of PBT and chemotherapy could improve OS in these patients.

scholarly journals The Usefulness of Using Fiducial Marker in Proton Therapy for Locally Advanced Pancreatic Cancer

2016 ◽  
Vol 72 (11) ◽  
pp. 1074-1083
Author(s):  
Masakazu Shimizu ◽  
Takahiro Sato ◽  
Yoshihide Sawa ◽  
Kazuki Terashima ◽  
Toshihiro Yanou ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Proton Therapy ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Fiducial Marker ◽  
Locally Advanced Pancreatic Cancer
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