scholarly journals Predicting the effect of indirect cell kill in the treatment of multiple brain metastases via single‐isocenter/multitarget volumetric modulated arc therapy stereotactic radiosurgery

2021 ◽  
Vol 22 (10) ◽  
pp. 94-103
Author(s):  
Allison N Palmiero ◽  
Denise Fabian ◽  
Marcus E Randall ◽  
William Clair ◽  
Damodar Pokhrel
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Volumetric Modulated Arc Therapy ◽  
Multiple Brain Metastases ◽  
Arc Therapy ◽  
Cell Kill ◽  
Single Isocenter

scholarly journals Operation and calibration of the novel PTW 1600SRS detector for the verification of single isocenter stereotactic radiosurgery treatments of multiple small brain metastases

2021 ◽  
pp. 20210473
Author(s):  
Esther Decabooter ◽  
Ans CC Swinnen ◽  
Michel C Öllers ◽  
Fabian Göpfert ◽  
Frank Verhaegen
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Volumetric Modulated Arc Therapy ◽  
Calibration Procedure ◽  
Accurate Solution ◽  
Array Detector ◽  
Multiple Brain Metastases ◽  
Flattening Filter Free ◽  
Cross Calibration ◽  
Single Isocenter

Objectives: The aim of this work was to evaluate the operation of the 1600SRS detector and to develop a calibration procedure for verifying the dose delivered by a single isocenter stereotactic radiosurgery (SRS) treatment of small multiple brain metastases (BM). Methods: 14 clinical treatment cases were selected with the number of BM ranging from 2 to 11. The dosimetric agreement was investigated between the calculated and the measured dose by an OCTAVIUS 1600SRS array detector in an OCTAVIUS 4D phantom equipped with dedicated SRS top. The cross-calibration procedure deviated from the manufacturer’s as it applied field sizes and dose rates corresponding to the volumetric modulated arc therapy segments in each plan. Results: Measurements with a plan specific cross-calibration showed mean ± standard deviation (SD) agreement scores for cut-off values 50%, 80%, 95%, of 98.6 ± 1.7%, 96.5 ± 4.6%, 97.3 ± 4.4% for the 6 MV plans respectively, and 98.6 ± 1.5%, 96.6 ± 4.0% 96.4 ± 6.3%, for the 6 MV flattening filter free (FFF) plans respectively. Using the default calibration procedure instead of the plan specific calibration could lead to a combined systematic dose offset of 4.1% for our treatment plans. Conclusion: The 1600SRS detector array with the 4D phantom offers an accurate solution to perform routine quality assurance measurements of single isocenter SRS treatments of multiple BM. This work points out the necessity of an adapted cross-calibration procedure. Advances in knowledge: A dedicated calibration procedure enables accurate dosimetry with the 1600SRS detector for small field single isocenter SRS treatment of multiple brain metastases for a large amount of BM.

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