scholarly journals A simple dosimetric approach to spatially fractionated GRID radiation therapy using the multileaf collimator for treatment of breast cancers in the prone position

2020 ◽  
Vol 21 (11) ◽  
pp. 105-114
Author(s):  
Natasha L. Murphy ◽  
Rino Philip ◽  
Matt Wozniak ◽  
Brian H. Lee ◽  
Eric D. Donnelly ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Prone Position ◽  
Multileaf Collimator ◽  
Breast Cancers

Extra-target doses in children receiving multileaf collimator (MLC) based intensity modulated radiation therapy (IMRT)

2004 ◽  
Vol 42 (7) ◽  
pp. 626-630 ◽  
Author(s):  
Mary Koshy ◽  
Arnold C. Paulino ◽  
Robert B. Marcus ◽  
Joseph Y. Ting ◽  
Daisy Whitaker ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Multileaf Collimator ◽  
Intensity Modulated

Surgery and radiation therapy of triple-negative breast cancers: From biology to clinics

The Breast ◽  
2016 ◽  
Vol 28 ◽  
pp. 148-155 ◽  
Author(s):  
Jacques Bernier ◽  
Philip M.P. Poortmans
Keyword(s):  
Radiation Therapy ◽  
Triple Negative ◽  
Breast Cancers

scholarly journals Tribbles Homolog 3 Involved in Radiation Response of Triple Negative Breast Cancer Cells by Regulating Notch1 Activation

Cancers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 127 ◽  
Author(s):  
Yueh-Chun Lee ◽  
Wen-Ling Wang ◽  
Wei-Chao Chang ◽  
Yu-Hao Huang ◽  
Guan-Ci Hong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Triple Negative ◽  
Mass Spectrometry Analysis ◽  
Radiation Response ◽  
Stem Cell Population ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Poor Prognostic Factor

Breast cancer is the most common cancer for women in Taiwan and post-lumpectomy radiotherapy is one of the therapeutic strategies for this malignancy. Although the 10-year overall survival of breast cancer patients is greatly improved by radiotherapy, the locoregional recurrence is around 10% and triple negative breast cancers (TNBCs) are at a high risk for relapse. The aim of this paper is to understand the mechanisms of radioresistance in breast cancers which may facilitate the development of new treatments in sensitizing breast cancer toward radiation therapy. Tribbles homolog 3 (TRIB3) is a pseudokinase protein and known to function as a protein scaffold within cells. It has been reported that higher TRIB3 expression is a poor prognostic factor in breast cancer patients with radiotherapy. In this study, we investigate the involvement of TRIB3 in the radiation response of TNBC cells. We first found that the expression of TRIB3 and the activation of Notch1, as well as Notch1 target genes, increased in two radioresistant TNBC cells. Knockdown of TRIB3 in radioresistant MDA-MB-231 TNBC cells decreased Notch1 activation, as well as the CD24-CD44+ cancer stem cell population, and sensitized cells toward radiation treatment. The inhibitory effects of TRIB3 knockdown in self-renewal or radioresistance could be reversed by forced expression of the Notch intracellular domain. We also observed an inhibition in cell growth and accumulated cells in the G0/G1 phase in radioresistant MDA-MB-231 cells after knockdown of TRIB3. With immunoprecipitation and mass spectrometry analysis, we found that, BCL2-associated transcription factor 1 (BCLAF1), BCL2 interacting protein 1 (BNIP1), or DEAD-box helicase 5 (DDX5) were the possible TRIB3 interacting proteins and immunoprecipitation data also confirmed that these proteins interacted with TRIB3 in radioresistant MDA-MB-231 cells. In conclusion, the expression of TRIB3 in radioresistant TNBC cells participated in Notch1 activation and targeted TRIB3 expression may be a strategy to sensitize TNBC cells toward radiation therapy.

SU-FF-T-307: A Multileaf Collimator Quality Assurance Tool for Modulated Electron Radiation Therapy

2009 ◽  
Vol 36 (6Part13) ◽  
pp. 2592-2592 ◽  
Author(s):  
I Emam ◽  
J Fan ◽  
L Jin ◽  
A El DIB ◽  
C Ma
Keyword(s):  
Quality Assurance ◽  
Radiation Therapy ◽  
Electron Radiation ◽  
Multileaf Collimator
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