scholarly journals Evaluation of a new secondary dose calculation software for Gamma Knife radiosurgery

2020 ◽  
Vol 21 (1) ◽  
pp. 95-102
Author(s):  
Michael T. Prusator ◽  
Tianyu Zhao ◽  
James A. Kavanaugh ◽  
Lakshmi Santanam ◽  
Joe Dise ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Dose Calculation ◽  
Calculation Software ◽  
Secondary Dose

PC-based gamma knife radiosurgery dose calculation

2003 ◽  
Vol 22 (5) ◽  
pp. 92-107 ◽  
Author(s):  
Y.J. Tsneg ◽  
H.H. Chang ◽  
C.Y. Shiau ◽  
W.Y. Chung ◽  
D.H.C. Pan ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Dose Calculation

scholarly journals Gamma Knife radiosurgery with CT image-based dose calculation

2015 ◽  
Vol 16 (6) ◽  
pp. 119-129 ◽  
Author(s):  
Andy Yuanguang Xu ◽  
Jagdish Bhatnagar ◽  
Greg Bednarz ◽  
Ajay Niranjan ◽  
Douglas Kondziolka ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Dose Calculation ◽  
Ct Image

scholarly journals Dosimetric effects of Onyx embolization on Gamma Knife arteriovenous malformation dose distributions

2016 ◽  
Vol 125 (Supplement_1) ◽  
pp. 114-122 ◽  
Author(s):  
David J. Schlesinger ◽  
Håkan Nordström ◽  
Anders Lundin ◽  
Zhiyuan Xu ◽  
Jason P. Sheehan
Keyword(s):  
Gamma Knife ◽  
Radiation Effects ◽  
Gamma Knife Radiosurgery ◽  
Dose Calculation ◽  
Clinical Results ◽  
Detectable Effect ◽  
Dose Distributions ◽  
Passing Rates ◽  
Dose Metrics ◽  
The Mean

OBJECTIVEPatients with arteriovenous malformations (AVMs) treated with Gamma Knife radiosurgery (GKRS) subsequent to embolization suffer from elevated local failure rates and differences in adverse radiation effects. Onyx is a common embolic material for AVMs. Onyx is formulated with tantalum, a high atomic number (Z = 73) element that has been investigated as a source of dosimetric uncertainty contributing to the less favorable clinical results. However, prior studies have not modeled the complicated anatomical and beam geometries characteristic of GKRS. This study investigated the magnitude of dose perturbation that can occur due to Onyx embolization using clinically realistic anatomical and Gamma Knife beam models.METHODSLeksell GammaPlan (LGP) was used to segment the AVM nidus and areas of Onyx from postcontrast stereotactic MRI for 7 patients treated with GKRS postembolization. The resulting contours, skull surface, and clinically selected dose distributions were exported from LGP in DICOM-RT (Digital Imaging and Communications in Medicine–radiotherapy) format. Isocenter locations and dwell times were recorded from the LGP database. Contours were converted into 3D mesh representations using commercial and in-house mesh-editing software. The resulting data were imported into a Monte Carlo (MC) dose calculation engine (Pegasos, Elekta Instruments AB) with a beam geometry for the Gamma Knife Perfexion. The MC-predicted dose distributions were calculated with Onyx assigned manufacturer-reported physical constants (MC-Onyx), and then compared with corresponding distributions in which Onyx was reassigned constants for water (MC-water). Differences in dose metrics were determined, including minimum, maximum, and mean dose to the AVM nidus; selectivity index; and target coverage. Combined differences in dose magnitude and distance to agreement were calculated as 3D Gamma analysis passing rates using tolerance criteria of 0.5%/0.5 mm, 1.0%/1.0 mm, and 3.0%/3.0 mm.RESULTSOverall, the mean percentage differences in dose metrics for MC-Onyx relative to MC-water were as follows; all data are reported as mean (SD): minimum dose to AVM = −0.7% (1.4%), mean dose to AVM = 0.1% (0.2%), maximum dose to AVM = 2.9% (5.0%), selectivity = 0.1% (0.2%), and coverage = −0.0% (0.2%). The mean percentage of voxels passing at each Gamma tolerance were as follows: 99.7% (0.1%) for 3.0%/3.0 mm, 98.2% (0.7%) for 1.0%/1.0 mm, and 52.1% (4.4%) for 0.5%/0.5 mm.CONCLUSIONSOnyx embolization appears to have a detectable effect on the delivered dose distribution. However, the small changes in dose metrics and high Gamma passing rates at 1.0%/1.0 mm tolerance suggest that these changes are unlikely to be clinically significant. Additional sources of delivery and biological uncertainty should be investigated to determine the root cause of the observed less favorable postembolization GKRS outcomes.

The Effect of Gamma Knife Radiosurgery on the Molecular Biology of Meningiomas

2014 ◽  
Vol 75 (S 02) ◽  
Author(s):  
V. Bulthuis ◽  
W. De Jong ◽  
Y. Yakkioui ◽  
P. Hanssens ◽  
Y. Temel ◽  
...  
Keyword(s):  
Molecular Biology ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery

Delayed CSF Rhinorrhea after Gamma Knife Radiosurgery with or Without Preceding Transsphenoidal Hypophysectomy for Pituitary Pathology

2016 ◽  
Vol 77 (S 01) ◽  
Author(s):  
Avital Perry ◽  
Christopher Graffeo ◽  
William Copeland ◽  
Kathryn Van Abel ◽  
Matthew Carlson ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Csf Rhinorrhea
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