scholarly journals Three discipline collaborative radiation therapy (3DCRT) special debate: The single most important factor in determining the future of SBRT is immune response

2019 ◽  
Vol 20 (10) ◽  
pp. 6-12 ◽  
Author(s):  
Clemens Grassberger ◽  
Kathryn Huber ◽  
Naduparambil K. Jacob ◽  
Michael D. Green ◽  
Peter Mahler ◽  
...  
Keyword(s):  
Immune Response ◽  
Radiation Therapy ◽  
The Future

scholarly journals Combining PARP inhibition, radiation, and immunotherapy: A possible strategy to improve the treatment of cancer?

2018 ◽  
Vol 19 (12) ◽  
pp. 3793 ◽  
Author(s):  
Mathieu Césaire ◽  
Juliette Thariat ◽  
Serge M. Candéias ◽  
Dinu Stefan ◽  
Yannick Saintigny ◽  
...  
Keyword(s):  
Immune Response ◽  
Radiation Therapy ◽  
T Lymphocytes ◽  
Ionizing Radiation ◽  
Cytotoxic T Lymphocytes ◽  
Tumor Antigens ◽  
Checkpoint Inhibitors ◽  
Parp Inhibitors ◽  
Antitumor Immune Response ◽  
Parp Inhibition

Immunotherapy has revolutionized the practice of oncology, improving survival in certain groups of patients with cancer. Immunotherapy can synergize with radiation therapy, increase locoregional control, and have abscopal effects. Combining it with other treatments, such as targeted therapies, is a promising means of improving the efficacy of immunotherapy. Because the value of immunotherapy is amplified with the expression of tumor antigens, coupling poly(ADP-ribose) polymerase (PARP) inhibitors and immunotherapy might be a promising treatment for cancer. Further, PARP inhibitors (PARPis) are being combined with radiation therapy to inhibit DNA repair functions, thus enhancing the effects of radiation; this association might interact with the antitumor immune response. Cytotoxic T lymphocytes are central to the antitumor immune response. PARP inhibitors and ionizing radiation can enhance the infiltration of cytotoxic T lymphocytes into the tumor bed, but they can also enhance PD-1/PDL-1 expression. Thus, the addition of immune checkpoint inhibitors with PARP inhibitors and/or ionizing radiation could counterbalance such immunosuppressive effects. With the present review article, we proposed to evaluate some of these associated therapies, and we explored the biological mechanisms and medical benefits of the potential combination of radiation therapy, immunotherapy, and PARP inhibitors.

scholarly journals P53 and The Immune Response: 40 Years of Exploration—A Plan for the Future

2020 ◽  
Vol 21 (2) ◽  
pp. 541 ◽  
Author(s):  
Arnold J. Levine
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Innate Immune System ◽  
P53 Protein ◽  
P53 Gene ◽  
T Cell Response ◽  
Innate Immune ◽  
Transplantation Antigen ◽  
Mutant Form ◽  
The Future

The p53 field was born from a marriage of the techniques of cancer virus research and immunology. Over the past 40 years, it has followed the path of cancer research. Now cancer treatments are turning to immunotherapy, and there are many hints of the role of the p53 protein in both the regulation of the innate immune system and as an antigen in adaptive immune responses. The p53 gene and protein are part of the innate immune system, and play an important role in infectious diseases, senescence, aging, and the surveillance of repetitive DNA and RNAs. The mutant form of the p53 protein in cancers elicits both a B-cell antibody response (a tumor antigen) and a CD-8 killer T-cell response (a tumor-specific transplantation antigen). The future will take the p53-immune response field of research into cancer immunotherapy, autoimmunity, inflammatory responses, neuro-degeneration, aging, and life span, and the regulation of epigenetic stability and tissue regeneration. The next 40 years will bring the p53 gene and its proteins out of a cancer focus and into an organismic and environmental focus.

Hafnium Oxide Nanoparticle Activated By Radiation Therapy Generates an Anti-Tumor Immune Response

2018 ◽  
Vol 102 (3) ◽  
pp. S204-S205 ◽  
Author(s):  
J. Galon ◽  
M. Laé ◽  
J.O. Thariat ◽  
S. Carrere ◽  
Z. Papai ◽  
...  
Keyword(s):  
Immune Response ◽  
Radiation Therapy ◽  
Hafnium Oxide ◽  
Oxide Nanoparticle

scholarly journals Spatially fractionated radiation therapy: History, present and the future

2020 ◽  
Vol 20 ◽  
pp. 30-38 ◽  
Author(s):  
Weisi Yan ◽  
Mohammad K. Khan ◽  
Xiaodong Wu ◽  
Charles B. Simone ◽  
Jiajin Fan ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
The Future ◽  
Fractionated Radiation Therapy ◽  
Fractionated Radiation
Sign in / Sign up

Export Citation Format

Share Document