scholarly journals Validation and clinical implementation of an accurate Monte Carlo code for pencil beam scanning proton therapy

2018 ◽  
Vol 19 (5) ◽  
pp. 558-572 ◽  
Author(s):  
Sheng Huang ◽  
Minglei Kang ◽  
Kevin Souris ◽  
Christopher Ainsley ◽  
Timothy D. Solberg ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Proton Therapy ◽  
Monte Carlo Code ◽  
Pencil Beam ◽  
Clinical Implementation ◽  
Beam Scanning ◽  
Pencil Beam Scanning

scholarly journals Clinical Implementation of Proton Therapy Using Pencil-Beam Scanning Delivery Combined With Static Apertures

2021 ◽  
Vol 11 ◽  
Author(s):  
Christian Bäumer ◽  
Sandija Plaude ◽  
Dalia Ahmad Khalil ◽  
Dirk Geismar ◽  
Paul-Heinz Kramer ◽  
...  
Keyword(s):  
At Risk ◽  
Proton Therapy ◽  
Target Volume ◽  
Delivery Mode ◽  
Pencil Beam ◽  
Clinical Implementation ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Spot Scanning ◽  
The Mean

Proton therapy makes use of the favorable depth-dose distribution with its characteristic Bragg peak to spare normal tissue distal of the target volume. A steep dose gradient would be desired in lateral dimensions, too. The widespread spot scanning delivery technique is based, however, on pencil-beams with in-air spot full-widths-at-half-maximum of typically 1 cm or more. This hampers the sparing of organs-at-risk if small-scale structures adjacent to the target volume are concerned. The trimming of spot scanning fields with collimating apertures constitutes a simple measure to increase the transversal dose gradient. The current study describes the clinical implementation of brass apertures in conjunction with the pencil-beam scanning delivery mode at a horizontal, clinical treatment head based on commercial hardware and software components. Furthermore, clinical cases, which comprised craniopharyngiomas, re-irradiations and ocular tumors, were evaluated. The dosimetric benefits of 31 treatment plans using apertures were compared to the corresponding plans without aperture. Furthermore, an overview of the radiation protection aspects is given. Regarding the results, robust optimization considering range and setup uncertainties was combined with apertures. The treatment plan optimizations followed a single-field uniform dose or a restricted multi-field optimization approach. Robustness evaluation was expanded to account for possible deviations of the center of the pencil-beam delivery and the mechanical center of the aperture holder. Supplementary apertures improved the conformity index on average by 15.3%. The volume of the dose gradient surrounding the PTV (evaluated between 80 and 20% dose levels) was decreased on average by 17.6%. The mean dose of the hippocampi could be reduced on average by 2.9 GyRBE. In particular cases the apertures facilitated a sparing of an organ-at-risk, e.g. the eye lens or the brainstem. For six craniopharyngioma cases the inclusion of apertures led to a reduction of the mean dose of 1.5 GyRBE (13%) for the brain and 3.1 GyRBE (16%) for the hippocampi.

scholarly journals Experimental and Monte Carlo characterization of a dynamic collimation system prototype for pencil beam scanning proton therapy

2020 ◽  
Vol 47 (10) ◽  
pp. 5343-5356
Author(s):  
Blake R. Smith ◽  
Mark Pankuch ◽  
Daniel E. Hyer ◽  
Wesley S. Culberson
Keyword(s):  
Monte Carlo ◽  
Proton Therapy ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Collimation System ◽  
System Prototype

scholarly journals Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy

2012 ◽  
Vol 57 (10) ◽  
pp. 2829-2842 ◽  
Author(s):  
Stephen J Dowdell ◽  
Benjamin Clasie ◽  
Nicolas Depauw ◽  
Peter Metcalfe ◽  
Anatoly B Rosenfeld ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Proton Therapy ◽  
Monte Carlo Study ◽  
Patient Specific ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Potential Reduction ◽  
Pencil Beam Scanning

Development and validation of the Dynamic Collimation Monte Carlo simulation package for pencil beam scanning proton therapy

2021 ◽  
Author(s):  
Nicholas P. Nelson ◽  
Wesley S. Culberson ◽  
Daniel E. Hyer ◽  
Theodore J. Geoghegan ◽  
Kaustubh A. Patwardhan ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Proton Therapy ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Development And Validation ◽  
Simulation Package

Developing a Monte Carlo model for MEVION S250i with HYPERSCAN and Adaptive Aperture™ pencil beam scanning proton therapy system

2020 ◽  
pp. 1-8
Author(s):  
Bing-Hao Chiang ◽  
Austin Bunker ◽  
Hosang Jin ◽  
Salahuddin Ahmad ◽  
Yong Chen
Keyword(s):  
Monte Carlo ◽  
Proton Therapy ◽  
Monte Carlo Model ◽  
Particle Simulation ◽  
Planning System ◽  
Treatment Planning System ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Beam Characteristics

Abstract Aim: As the number of proton therapy facilities has steadily increased, the need for the tool to provide precise dose simulation for complicated clinical and research scenarios also increase. In this study, the treatment head of Mevion HYPERSCAN pencil beam scanning (PBS) proton therapy system including energy modulation system (EMS) and Adaptive Aperture™ (AA) was modelled using TOPAS (TOolkit for PArticle Simulation) Monte Carlo (MC) code and was validated during commissioning process. Materials and methods: The proton beam characteristics including integral depth doses (IDDs) of pristine Bragg peak and in-air beam spot sizes were simulated and compared with measured beam data. The lateral profiles, with and without AA, were also verified against calculation from treatment planning system (TPS). Results: All beam characteristics for IDDs and in-air spot size agreed well within 1 mm and 10% separately. The full width at half maximum and penumbra of lateral dose profile also agree well within 2 mm. Finding: The TOPAS MC simulation of the MEVION HYPERSCAN PBS proton therapy system has been modelled and validated; it could be a viable tool for research and verification of the proton treatment in the future.

PO-1611: Clinical implementation of liver cancer treatments with pencil beam scanning proton therapy

2020 ◽  
Vol 152 ◽  
pp. S877
Author(s):  
F. Fracchiolla ◽  
F. Dionisi ◽  
R. Righetto ◽  
L. Widesott ◽  
I. Giacomelli ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Proton Therapy ◽  
Pencil Beam ◽  
Clinical Implementation ◽  
Cancer Treatments ◽  
Beam Scanning ◽  
Pencil Beam Scanning
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