It's more than skin‐deep: The relationship between social victimization and telomere length in adolescence

2018 ◽  
Vol 44 (4) ◽  
pp. 337-347 ◽  
Author(s):  
Maria E. Guarneri‐White ◽  
Allyson A. Arana ◽  
Erin Q. Boyd ◽  
Lauri A. Jensen‐Campbell
Keyword(s):  
Telomere Length ◽  
Social Victimization ◽  
The Relationship

scholarly journals The relationship of telomere length to baseline corticosterone levels in nestlings of an altricial passerine bird in natural populations

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Verónica Quirici ◽  
Claudia Jimena Guerrero ◽  
Jesse S. Krause ◽  
John C. Wingfield ◽  
Rodrigo A. Vásquez
Keyword(s):  
Telomere Length ◽  
Natural Populations ◽  
Passerine Bird ◽  
Baseline Corticosterone ◽  
Relationship Of ◽  
The Relationship

scholarly journals Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort

2019 ◽  
Vol 20 (12) ◽  
pp. 3032 ◽  
Author(s):  
Verena L. Banszerus ◽  
Valentin M. Vetter ◽  
Bastian Salewsky ◽  
Maximilian König ◽  
Ilja Demuth
Keyword(s):  
Telomere Length ◽  
Penalized Regression ◽  
Biological Age ◽  
Chronological Age ◽  
Epigenetic Clock ◽  
Single Nucleotide ◽  
Epigenetic Age ◽  
High Prevalence ◽  
Relationship Of ◽  
The Relationship

Telomere length has been accepted widely as a biomarker of aging. Recently, a novel candidate biomarker has been suggested to predict an individual’s chronological age with high accuracy: The epigenetic clock is based on the weighted DNA methylation (DNAm) fraction of a number of cytosine-phosphate-guanine sites (CpGs) selected by penalized regression analysis. Here, an established methylation-sensitive single nucleotide primer extension method was adapted, to estimate the epigenetic age of the 1005 participants of the LipidCardio Study, a patient cohort characterised by high prevalence of cardiovascular disease, based on a seven CpGs epigenetic clock. Furthermore, we measured relative leukocyte telomere length (rLTL) to assess the relationship between the established and the promising new measure of biological age. Both rLTL (0.79 ± 0.14) and DNAm age (69.67 ± 7.27 years) were available for 773 subjects (31.6% female; mean chronological age= 69.68 ± 11.01 years; mean DNAm age acceleration = −0.01 ± 7.83 years). While we detected a significant correlation between chronological age and DNAm age (n = 779, R = 0.69), we found neither evidence of an association between rLTL and the DNAm age (β = 3.00, p = 0.18) nor rLTL and the DNAm age acceleration (β = 2.76, p = 0.22) in the studied cohort, suggesting that DNAm age and rLTL measure different aspects of biological age.

scholarly journals Expression of Shelterin ComponentPOT1Is Associated with Decreased Telomere Length and Immunity Condition in Humans with Severe Aplastic Anemia

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ting Wang ◽  
Shu-chong Mei ◽  
Rong Fu ◽  
Hua-quan Wang ◽  
Zong-hong Shao
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Telomere Length ◽  
Bone Marrow Cells ◽  
Culture Media ◽  
Telomere Attrition ◽  
High Concentrations ◽  
Relationship Of ◽  
The Relationship ◽  
Marrow Cells

Abnormal telomere attrition has been found to be closely related to patients with SAA in recent years. To identify the incidence of telomere attrition in SAA patients and investigate the relationship of telomere length with clinical parameters, SAA patients(n=27)and healthy controls(n=15)were enrolled in this study. Telomere length of PWBCs was significantly shorter in SAA patients than in controls. Analysis of gene expression of Shelterin complex revealed markedly low levels ofPOT1expression in SAA groups relative to controls. No differences in the gene expression of the other Shelterin components—TRF1,TRF2,TIN2,TPP1, andRAP1—were identified. Addition of IFN-γto culture media induced a similar fall in POT1 expression in bone marrow cells to that observed in cells cultured in the presence of SAA serum, suggesting IFN-γis the agent responsible for this effect of SAA serum. Furthermore, ATR, phosphorylated ATR, and phosphorylated ATM/ATR substrate were all found similarly increased in bone marrow cells exposed to SAA serum, TNF-α, or IFN-γ. In summary, SAA patients have short telomeres and decreased POT1 expression. TNF-αand IFN-γare found at high concentrations in SAA patients and may be the effectors that trigger apoptosis through POT1 and ATR.

scholarly journals The relationship between naevus count, memory function and telomere length in the Twins UK cohort

2018 ◽  
Vol 31 (6) ◽  
pp. 720-724 ◽  
Author(s):  
Stefano Masi ◽  
Georgios Georgiopoulos ◽  
Simone Ribero ◽  
Stefano Taddei ◽  
Veronique Bataille ◽  
...  
Keyword(s):  
Telomere Length ◽  
Memory Function ◽  
The Relationship

scholarly journals The Relationship between Telomere Length and Gestational Weight Gain: Findings from the Mamma & Bambino Cohort

Biomedicines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 67
Author(s):  
Andrea Maugeri ◽  
Roberta Magnano San Lio ◽  
Maria Clara La Rosa ◽  
Giuliana Giunta ◽  
Marco Panella ◽  
...  
Keyword(s):  
Weight Gain ◽  
Telomere Length ◽  
Gestational Weight Gain ◽  
Molecular Mechanisms ◽  
Quantitative Polymerase Chain Reaction ◽  
Well Being ◽  
Early Effect ◽  
Gestational Weight ◽  
Relative Telomere Length ◽  
The Relationship

Inadequate gestational weight gain (GWG) affects a growing number of pregnancies, influencing intrauterine environment and long-term health. Uncovering molecular mechanisms associated with GWG could be helpful to develop public health strategies for tackling this issue. Here, our study aimed to understand the relationship of DNA telomere length with weigh gain during pregnancy, using data and samples from the ongoing prospective “Mamma & Bambino” study (Catania, Italy). GWG was calculated according to the Institute of Medicine (IOM) guidelines. Relative telomere length was assessed by real-time quantitative polymerase chain reaction in 252 samples of maternal leucocyte DNA (mlDNA) and 150 samples of cell-free DNA (cfDNA) from amniotic fluid. We observed that relative telomere length of mlDNA seemed to weakly increase with GWG. In contrast, telomere length of cfDNA exhibited a U-shaped relationship with GWG. Women with adequate GWG showed longer telomere length than those who gained weight inadequately. Accordingly, the logistic regression model confirmed the association between telomere length of cfDNA and adequate GWG, after adjusting for potential confounders. Our findings suggest an early effect of GWG on telomere length of cfDNA, which could represent a molecular mechanism underpinning the effects of maternal behaviours on foetal well-being.

scholarly journals Age Adjusted Telomere Length Decreases Following Treatment for Pediatric Acute Lymphoblastic Leukemia, but Does Not Predict Toxicity

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4984-4984 ◽  
Author(s):  
Pasquale M Barbaro ◽  
Marion Mateos ◽  
Luciano Dalla-Pozza ◽  
Anthea Ng ◽  
Glenn M Marshall ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Telomere Length ◽  
Lymphoblastic Leukemia ◽  
Children's Hospital ◽  
Organ Toxicity ◽  
End Of Treatment ◽  
Children’S Hospital ◽  
The Relationship ◽  
Telomere Dynamics

Abstract Introduction Telomeres are specialized DNA structures found at the end of linear chromosomes, which in humans contains the repetitive DNA sequence, (TTAGGG)n and associated proteins. Telomere length (TL) is important for replicative capacity of cells, and, in somatic cells, telomere length shortens with each cell division. Once a critically short length is reached, cells enter senescence or undergo apoptosis. In the general population, TL varies greatly and declines with age. Chemotherapy can increase the rate of telomere shortening, although these findings have not been consistently demonstrated. There is evidence, mostly in adults, suggesting that patients with shorter TL experience increased toxicity from cancer treatment. Patients with the short telomere syndrome, Dyskeratosis Congenita undergoing hematopoietic stem cell transplantation have increased rates and degree of organ toxicity when given myeloablative conditioning. In the pediatric population there have been no studies assessing the relationship between TL and rates of toxicity after chemotherapy, and few investigating telomere dynamics following chemotherapy. We undertook a retrospective analysis to investigate the relationship between TL and chemotherapy toxicity, and also telomere dynamics in children treated for acute lymphoblastic leukemia (ALL). Methods Patients enrolled on the Australian and New Zealand Children's Hematology and Oncology Group's (ANZCHOG) Study 8 for ALL at the Children's Hospital at Westmead and the Sydney Children's Hospital from October 2002 to November 2011 who had provided consent and who had stored samples suitable for TL analysis were included in the study. Organ toxicity information was collected from the Study 8 database, as well as examination of patient medical records and pathology information systems. Liver and renal toxicities were documented based on abnormalities in transaminases, bilirubin and creatinine respectively. Pulmonary and neurotoxicities were determined through medical record and imaging findings. Standard common terminology criteria for adverse events (CTCAE) criteria were used to systematically grade toxicity. Infectious disease information and intensive care admissions as well as time to complete each cycle of therapy were used as surrogate markers for toxicity and bone marrow recovery. Survival and relapse rates were also analyzed. Relative TL was measured using a quantitative PCR technique on DNA extracted from mononuclear cells taken at Day 79 following commencement of induction and consolidation therapy, and also at the end of treatment, typically 24 months from diagnosis. The relative TL was converted to an age adjusted TL (AATL) by subtracting the expected relative TL (i.e. 50th percentile for age of the patient) from the measured relative TL, so that patients of all ages could be analyzed together. For analysis the cohort was separated into four groups based on AATL quartiles. Results In all, 460 patients with research consent were enrolled on ANZCHOG ALL Study 8 at the 2 hospitals included in this study. Of these 157 patients with AATL measurement and toxicity information were included in our analysis with 149 being standard or medium risk. The median age of diagnosis was 4.79 years (range 1.1 - 17.89) with a median follow up of 53 months (range 9-124 months). The median AATL on Day 79 was 0.035 (range -0.41 to 0.73). The average change in TL from day 79 to end of treatment was -0.126 (range -0.81 to 0.40), which is equivalent to approximately 8-10 years of natural ageing. There was no significant association between survival (Figure 1) or rates of grade 3 or 4 organ toxicity, relapse (Table 2) or bone marrow recovery and AATL. Renal toxicity was significantly increased in the second shortest quartile, however numbers are small (4 patients in second quartile vs 1 in fourth quartile). Conclusion There is an increased rate of telomere attrition during treatment for childhood ALL, however telomere length does not appear to be associated with increased rates of organ toxicity. Support: NHMRC APP1057746 and NHMRC GNT1056667 Disclosures No relevant conflicts of interest to declare.

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