Beneficial Effect of Naturally Occurring Antioxidants against Oxidative Stress-Mediated Organ Dysfunctions

2015 ◽  
pp. 199-240
Author(s):  
Pabitra B. Pal ◽  
Shatadal Ghosh ◽  
Parames C. Sil
Keyword(s):  
Oxidative Stress ◽  
Beneficial Effect ◽  
Naturally Occurring ◽  
Organ Dysfunctions

scholarly journals Beneficial Effect of Aqueous Garlic Extract on Inflammation and Oxidative Stress Status in the Kidneys of Type 1 Diabetic Rats

2016 ◽  
Vol 32 (3) ◽  
pp. 329-336 ◽  
Author(s):  
Abolfazl Nasiri ◽  
Nasrin Ziamajidi ◽  
Roghayeh Abbasalipourkabir ◽  
Mohammad Taghi Goodarzi ◽  
Massoud Saidijam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beneficial Effect ◽  
Diabetic Rats ◽  
Garlic Extract ◽  
Oxidative Stress Status ◽  
And Oxidative Stress

Amelioration of oxidative stress by dietary fenugreek (Trigonella foenum-graecum L.) seeds is potentiated by onion (Allium cepa L.) in streptozotocin-induced diabetic rats

2017 ◽  
Vol 42 (8) ◽  
pp. 816-828 ◽  
Author(s):  
Seetur R. Pradeep ◽  
Krishnapura Srinivasan
Keyword(s):  
Oxidative Stress ◽  
Beneficial Effect ◽  
Allium Cepa ◽  
Diabetic Rats ◽  
Dietary Interventions ◽  
Fenugreek Seeds ◽  
Soluble Fibre ◽  
Trigonella Foenum Graecum ◽  
Allium Cepa L ◽  
Trigonella Foenum Graecum L

Oxidative stress has a crucial role in the progression of diabetes and its complications. Soluble fibre-rich fenugreek seeds (Trigonella foenum-graecum L.) are understood to have a beneficial effect in the management of diabetes. Previously, we have shown that the amelioration of diabetic hyperglycemia and related metabolic abnormalities was potentiated by onion (Allium cepa L.) in experimental rats. The present study evaluated the additive beneficial effect of dietary fenugreek seeds (10%) and onion (3%) on oxidative stress in diabetic rats. These dietary interventions lowered oxidative stress, the combination producing a higher beneficial effect (p < 0.05), although not additive. Dietary fenugreek, onion, or fenugreek+onion countered hypercholesterolemia (p < 0.05), especially from low-density lipoprotein−associated fraction by 43%, 35%, and 54%, respectively. Elevated concentrations of cholesterol and triglycerides in the liver and heart under diabetic conditions were significantly counteracted by these dietary interventions, with the additive combination resulting in greater effect. These findings were also corroborated by restoration of histopathological abnormalities of heart and liver tissues along with lowered heart and liver weights. It is inferred that an alleviation of oxidative stress contributes further to the antidiabetic influence and this nutraceutical potential of fenugreek seeds and onion was higher when consumed together.

scholarly journals Beneficial Effect of Nutrisim© against LPS-Induced Liver Injury: Oxidative Stress Markers and Mitochondrial ATP-ase Activity

2012 ◽  
Vol 7 (1) ◽  
pp. 38-46
Author(s):  
Erandis D. Torres- ◽  
Erika D. Gonzale ◽  
Fermin P. Pacheco ◽  
Rolando Romero-Dav ◽  
Luis A. Romero- ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Beneficial Effect ◽  
Oxidative Stress Markers ◽  
Stress Markers

scholarly journals Queuine is a nutritional regulator of Entamoeba histolytica response to oxidative stress and a virulence attenuator

2020 ◽  
Author(s):  
Shruti Nagaraja ◽  
Maggi W. Cai ◽  
Jingjing Sun ◽  
Hugo Varet ◽  
Lotem Sarid ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Entamoeba Histolytica ◽  
Cysteine Proteases ◽  
Small Gtpases ◽  
Cytoskeletal Proteins ◽  
Transfer Rnas ◽  
Amebic Dysentery ◽  
Naturally Occurring ◽  
Expression Of Genes ◽  
Negative Effect

Queuosine is a naturally occurring modified ribonucleoside found in the first position of the anticodon of the transfer RNAs for Asp, Asn, His and Tyr. Eukaryotes lack pathways to synthesize queuine, the nucleobase precursor to queuosine, and must obtain it from diet or gut microbiota. Here we describe the effects of queuine on the physiology of the eukaryotic parasite, Entamoeba histolytica, the causative agent of amebic dysentery. Queuine is efficiently incorporated into E. histolytica tRNAs by a tRNA-guanine transglycosylase (EhTGT) and this incorporation stimulates the methylation of C38 in tRNAAspGUC. Queuine protects the parasite against oxidative stress (OS) and antagonizes the negative effect that oxidation has on translation by inducing the expression of genes involved in OS response, such as heat shock protein 70 (Hsp 70), antioxidant enzymes, and enzymes involved in DNA repair. On the other hand, queuine impairs E. histolytica virulence by downregulating the expression of genes previously associated with virulence, including cysteine proteases, cytoskeletal proteins, and small GTPases. Silencing of EhTGT prevents incorporation of queuine into tRNAs and strongly impairs methylation of C38 in tRNAAspGUC, parasite growth, resistance to OS, and cytopathic activity. Overall, our data reveal that queuine plays a dual role in promoting OS resistance and reducing parasite virulence.

scholarly journals Beneficial effect of 3-hydroxytyrosol on chondrocytes exposed to oxidative stress

2014 ◽  
Vol 22 ◽  
pp. S323-S324
Author(s):  
S. Cetrullo ◽  
S. D’Adamo ◽  
A. Facchini ◽  
S. Guidotti ◽  
M. Minguzzi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beneficial Effect

scholarly journals Melatonin Protects Band 3 Protein in Human Erythrocytes against H2O2-Induced Oxidative Stress

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2741 ◽  
Author(s):  
Rossana Morabito ◽  
Alessia Remigante ◽  
Angela Marino
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Protein Expression ◽  
Beneficial Effect ◽  
Anion Exchange ◽  
Rate Constant ◽  
Cell Shape ◽  
Band 3 ◽  
Band 3 Protein ◽  
Expression Levels

The beneficial effect of Melatonin (Mel), recognized as an anti-inflammatory and antioxidant compound, has been already proven to prevent oxidative stress-induced damage associated to lipid peroxidation. As previous studies modeled the impact of oxidative stress on Band 3 protein, an anion exchanger that is essential to erythrocytes homeostasis, by applying H2O2 at not hemolytic concentrations and not producing lipid peroxidation, the aim of the present work was to evaluate the possible antioxidant effect of pharmacological doses of Mel on Band 3 protein anion exchange capability. The experiments have been performed on human erythrocytes exposed to 300 μM H2O2-induced oxidative stress. To this end, oxidative damage has been verified by monitoring the rate constant for SO4= uptake through Band 3 protein. Expression levels of this protein Mel doses lower than 100 µM have also been excluded due to lipid peroxidation, Band 3 protein expression levels, and cell shape alterations, confirming a pro-oxidant action of Mel at certain doses. On the other hand, 100 µM Mel, not provoking lipid peroxidation, restored the rate constant for SO4= uptake, Band 3 protein expression levels, and H2O2-induced cell shape alterations. Such an effect was confirmed by abolishing the endogenous erythrocytes antioxidant system. Therefore, the present findings show the antioxidant power of Mel at pharmacological concentrations in an in vitro model of oxidative stress not associated to lipid peroxidation, thereby confirming Band 3 protein anion exchange capability measurement as a suitable model to prove the beneficial effect of Mel and support the use of this compound in oxidative stress-related diseases affecting Band 3 protein.

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