Chemical Biology of Protein Kinases

Kinomics ◽  
2015 ◽  
pp. 63-84
Author(s):  
David Mann
Keyword(s):  
Protein Kinases ◽  
Chemical Biology

scholarly journals Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential

2020 ◽  
Vol 21 (20) ◽  
pp. 7549
Author(s):  
Paula Martín Moyano ◽  
Václav Němec ◽  
Kamil Paruch
Keyword(s):  
Clinical Trials ◽  
Protein Kinases ◽  
Small Molecule ◽  
Chemical Biology ◽  
Small Molecule Inhibitors ◽  
Therapeutic Potential ◽  
Chemical Probes ◽  
The Family

Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds’ potential to be utilized as quality chemical biology probes.

Correction: Graduate Education in Chemical Biology at the University of Michigan

2006 ◽  
Vol 1 (9) ◽  
pp. 601
Author(s):  
Tonia J. Buchholz ◽  
Bruce Palfey ◽  
Anna K. Mapp ◽  
Gary D. Glick
Keyword(s):  
Graduate Education ◽  
Chemical Biology ◽  
University Of Michigan ◽  
The University
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