Alkoxyalkyl Ester Prodrugs of Antiviral Nucleoside Phosphates and Phosphonates

2011 ◽  
pp. 181-208 ◽  
Author(s):  
James R. Beadle ◽  
Karl Y. Hostetler
Keyword(s):  
Ester Prodrugs ◽  
Antiviral Nucleoside

Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase

2021 ◽  
pp. 100391
Author(s):  
Masato Takahashi ◽  
Ibuki Hirota ◽  
Tomoyuki Nakano ◽  
Tomoyuki Kotani ◽  
Daisuke Takani ◽  
...  
Keyword(s):  
Electron Density ◽  
Steric Hindrance ◽  
Metabolic Activation ◽  
Ester Prodrugs

Synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir

2005 ◽  
Vol 305 (1-2) ◽  
pp. 75-89 ◽  
Author(s):  
Kunal Patel ◽  
Shrija Trivedi ◽  
Shuanghui Luo ◽  
Xiaodong Zhu ◽  
Dhananjay Pal ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Antiviral Activities ◽  
Ester Prodrugs

scholarly journals Broad-Spectrum Antiviral Strategies and Nucleoside Analogues

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 667
Author(s):  
Robert J. Geraghty ◽  
Matthew T. Aliota ◽  
Laurent F. Bonnac
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Broad Spectrum ◽  
Vaccine Development ◽  
Fast Response ◽  
Mechanisms Of Action ◽  
Public Health Emergency ◽  
Nucleoside Analogues ◽  
The Family ◽  
Antiviral Nucleoside

The emergence or re-emergence of viruses with epidemic and/or pandemic potential, such as Ebola, Zika, Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus 1 and 2 (SARS and SARS-CoV-2) viruses, or new strains of influenza represents significant human health threats due to the absence of available treatments. Vaccines represent a key answer to control these viruses. However, in the case of a public health emergency, vaccine development, safety, and partial efficacy concerns may hinder their prompt deployment. Thus, developing broad-spectrum antiviral molecules for a fast response is essential to face an outbreak crisis as well as for bioweapon countermeasures. So far, broad-spectrum antivirals include two main categories: the family of drugs targeting the host-cell machinery essential for virus infection and replication, and the family of drugs directly targeting viruses. Among the molecules directly targeting viruses, nucleoside analogues form an essential class of broad-spectrum antiviral drugs. In this review, we will discuss the interest for broad-spectrum antiviral strategies and their limitations, with an emphasis on virus-targeted, broad-spectrum, antiviral nucleoside analogues and their mechanisms of action.

Enhanced delivery of ketobemidone through porcine buccal mucosa in vitro via more lipophilic ester prodrugs

1992 ◽  
Vol 88 (1-3) ◽  
pp. 237-242 ◽  
Author(s):  
Laila Bach Hansen ◽  
Lona Louring Christrup ◽  
Hans Bundgaard
Keyword(s):  
Buccal Mucosa ◽  
Ester Prodrugs

Influence of chain length on thein vitrohydrolysis of model ester prodrugs by ocular esterases

1982 ◽  
Vol 2 (10) ◽  
pp. 651-656 ◽  
Author(s):  
Shih-Chieh Chang ◽  
Vincent H.L. Lee
Keyword(s):  
Chain Length ◽  
Ester Prodrugs

Amido tyrosine esters: a promising new approach to antiviral nucleoside phosphonate prodrugs

2011 ◽  
Vol 90 (2) ◽  
pp. A23-A24
Author(s):  
Charles E. McKenna ◽  
Boris A. Kashemirov ◽  
Valeria M. Zakharova ◽  
Ivan S. Krylov ◽  
Melissa Williams ◽  
...  
Keyword(s):  
New Approach ◽  
Antiviral Nucleoside

Red Blood Cells as Advanced Drug Delivery Systems for Antiviral Nucleoside Analogues

1992 ◽  
pp. 239-245 ◽  
Author(s):  
Mauro Magnani ◽  
Luigia Rossi ◽  
Anna Casabianca ◽  
Alessandra Fraternale ◽  
Giuditta Schiavano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nucleoside Analogues ◽  
Antiviral Nucleoside
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