Methodological Issues for Clinical Treatment Trials in Obsessive-Compulsive Disorder

2012 ◽  
pp. 191-219 ◽  
Author(s):  
Samar Reghunandanan ◽  
Naomi A. Fineberg
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Clinical Treatment ◽  
Methodological Issues ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Treatment Trials

scholarly journals Translational approaches to obsessive-compulsive disorder: from animal models to clinical treatment

2011 ◽  
Vol 164 (4) ◽  
pp. 1044-1061 ◽  
Author(s):  
NA Fineberg ◽  
SR Chamberlain ◽  
E Hollander ◽  
V Boulougouris ◽  
TW Robbins
Keyword(s):  
Animal Models ◽  
Obsessive Compulsive Disorder ◽  
Clinical Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

WCA Recommendations for the Long-Term Treatment of Obsessive-Compulsive Disorder in Adults

CNS Spectrums ◽  
2003 ◽  
Vol 8 (S1) ◽  
pp. 7-16 ◽  
Author(s):  
John H. Greist ◽  
Borwin Bandelow ◽  
Eric Hollander ◽  
Donatella Marazziti ◽  
Stuart A. Montgomery ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Treatment Guidelines ◽  
Term Treatment ◽  
Tricyclic Antidepressant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Treatment Trials ◽  
Long Term Treatment

ABSTRACTWhat are the latest psychotherapeutic and pharmacotherapeutic treatment recommendations for obsessive-compulsive disorder (OCD)? OCD is a relatively common disorder with a lifetime prevalence of ~2% in the general population. It often has an early onset, usually in childhood or adolescence, and frequently becomes chronic and disabling if left untreated. High associated healthcare utilization and costs, and reduced productivity resulting in loss of earning, pose a huge economic burden to OCD patients and their families, employers, and society. OCD is characterized by the presence of obsessions and compulsions that are time-consuming, cause marked distress, or significantly interfere with a person's functioning. Most patients with OCD experience symptoms throughout their lives and benefit from long-term treatment. Both psychotherapy and pharmacotherapy are recommended, either alone or in combination, for the treatment of OCD. Cognitive-behavioral therapy is the psychotherapy of choice. Pharmacologic treatment options include the tricyclic antidepressant clomipramine and the selective serotonin reuptake inhibitors (SSRIs) citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline. These have all shown benefit in acute treatment trials; clomipramine, fluvoxamine, fluoxetine, and sertraline have also demonstrated benefit in long-term treatment trials (at least 24 weeks), and clomipramine, sertraline, and fluvoxamine have United States Food and Drug Administration approvals for use in children and adolescents. Available treatment guidelines recommend first-line use of an SSR1 (ie, fluoxetine, fluvoxamine, paroxetine, sertraline, or citalopram) in preference to clomipramine, due to the latter's less favorable adverse-event profile. Further, pharmacotherapy for a minimum of 1–2 years is recommended before very gradual withdrawal may be considered.

Treatment of Obsessive-Compulsive Disorder

CNS Spectrums ◽  
1999 ◽  
Vol 4 (S3) ◽  
pp. 46-50 ◽  
Author(s):  
Stuart A. Montgomery
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Serotonin Reuptake ◽  
Serotonin Receptor ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Clinical Treatment ◽  
Serotonin Reuptake Inhibitors ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Short And Long Term

AbstractAll the research to date implicates serotonin as the major neurotransmitter involved in obsessive-compulsive disorder (OCD). Much of the evidence has come from clinical treatment studies, which have shown the specific antiobsessional effect of drugs that are potent inhibitors of serotonin reuptake. Only the selective serotonin reuptake inhibitors (SSRIs) and the potent inhibitors of serotonin reuptake have been shown to be effective in treating patients with OCD. Serotonin receptor inhibitors and SSRIs have been thoroughly investigated in short- and long-term placebo-controlled studies and all have been found to be effective in OCD.

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