Industrial Applications - Case Studies

2017 ◽  
pp. 203-241
Keyword(s):  
Case Studies ◽  
Industrial Applications

scholarly journals VTR: an algorithm for identifying analogous contacts on protein structures and their complexes

2020 ◽  
Author(s):  
Vitor Pimentel ◽  
Diego Mariano ◽  
Letícia Xavier Silva Cantão ◽  
Luana Luiza Bastos ◽  
Pedro Fischer ◽  
...  
Keyword(s):  
Case Studies ◽  
Drug Targets ◽  
Rational Design ◽  
Structural Alignment ◽  
Protein Structures ◽  
Cell Receptor ◽  
Industrial Applications ◽  
Biofuel Production ◽  
Homologous Proteins ◽  
Related Proteins

Abstract Evolutionarily related proteins can present similar structures but very dissimilar sequences. Hence, understanding the role of the inter-residues contacts for the protein structure has been the target of many studies. Contacts comprise non-covalent interactions, which are essential to stabilize macromolecular structures such as proteins. Here we show VTR, a new method for the detection of analogous contacts in protein pairs. VTR performs structural alignment between proteins and detects interactions that occur in similar regions. To evaluate our tool, we proposed three case studies: (i) we compared a vertebrate myoglobin and a truncated invertebrate hemoglobin; (ii) analyzed interactions between the spike protein RBD of SARS-CoV-2 and the cell receptor ACE2; and (iii) compared a glucose-tolerant and a non-tolerant β-glucosidase enzyme used for biofuel production. The case studies demonstrate the potential of VTR for the understanding of functional similarities between distantly sequence-related proteins, as well as the exploration of important drug targets and rational design of enzymes for industrial applications. We envision VTR as a promising tool for understanding differences and similarities between homologous proteins with similar 3D structures but different sequences. VTR is available at http://bioinfo.dcc.ufmg.br/vtr.

scholarly journals VTR: A Web Tool for Identifying Analogous Contacts on Protein Structures and Their Complexes

2021 ◽  
Vol 1 ◽  
Author(s):  
Vitor Pimentel ◽  
Diego Mariano ◽  
Letícia Xavier Silva Cantão ◽  
Luana Luiza Bastos ◽  
Pedro Fischer ◽  
...  
Keyword(s):  
Case Studies ◽  
Drug Targets ◽  
Rational Design ◽  
Structural Alignment ◽  
Protein Structures ◽  
Industrial Applications ◽  
Biofuel Production ◽  
Web Tool ◽  
Homologous Proteins ◽  
Related Proteins

Evolutionarily related proteins can present similar structures but very dissimilar sequences. Hence, understanding the role of the inter-residues contacts for the protein structure has been the target of many studies. Contacts comprise non-covalent interactions, which are essential to stabilize macromolecular structures such as proteins. Here we show VTR, a new method for the detection of analogous contacts in protein pairs. The VTR web tool performs structural alignment between proteins and detects interactions that occur in similar regions. To evaluate our tool, we proposed three case studies: we 1) compared vertebrate myoglobin and truncated invertebrate hemoglobin; 2) analyzed interactions between the spike protein RBD of SARS-CoV-2 and the cell receptor ACE2; and 3) compared a glucose-tolerant and a non-tolerant β-glucosidase enzyme used for biofuel production. The case studies demonstrate the potential of VTR for the understanding of functional similarities between distantly sequence-related proteins, as well as the exploration of important drug targets and rational design of enzymes for industrial applications. We envision VTR as a promising tool for understanding differences and similarities between homologous proteins with similar 3D structures but different sequences. VTR is available at http://bioinfo.dcc.ufmg.br/vtr.

scholarly journals Flat-Top Cylinder Indenter for Mechanical Characterization: A Report of Industrial Applications

Materials ◽  
2021 ◽  
Vol 14 (7) ◽  
pp. 1742
Author(s):  
Roberto Montanari ◽  
Alessandra Varone
Keyword(s):  
Experimental Data ◽  
Mechanical Properties ◽  
Case Studies ◽  
Large Scale ◽  
Complex Geometry ◽  
Indentation Test ◽  
Experimental Tests ◽  
Industrial Applications ◽  
Heat Sinks ◽  
Deep Indentation

FIMEC (flat-top cylinder indenter for mechanical characterisation) is an instrumented indentation test employing a cylindrical punch. It has been used to determine the mechanical properties of metallic materials in several applications of industrial interest. This work briefly describes the technique and the theory of indentation with a flat-ended punch. The flat indentation of metals has been investigated through experimental tests, and an equation has been derived to calculate the yield stress from the experimental data in deep indentation. The approach is supported by many data on various metals and alloys. Some selected case studies are presented in the paper: (i) crank manufacturing through pin squeeze casting; (ii) the evaluation of the local mechanical properties in a carter of complex geometry; (iii) the qualification of Al billets for extrusion; (iv) stress–relaxation tests on CuCrZr heat sinks; (v) the characterization of thick W coatings on CuCrZr alloy; (vi) the measure of the local mechanical properties of the molten-zone (MZ) and the heat-affected zone (HAZ) in welded joints. The case studies demonstrate the great versatility of the FIMEC test which provides information not available by employing conventional experimental techniques such as tensile, bending, and hardness tests. On the basis of theoretical knowledge and large amount of experimental data, FIMEC has become a mature technique for application on a large scale in industrial practice.

scholarly journals VTR: an algorithm for identifying analogous contacts on protein structures and their complexes

2020 ◽  
Author(s):  
Vitor Pimentel ◽  
Diego Mariano ◽  
Letícia Xavier Silva Cantão ◽  
Luana Luiza Bastos ◽  
Pedro Fischer ◽  
...  
Keyword(s):  
Case Studies ◽  
Drug Targets ◽  
Rational Design ◽  
Structural Alignment ◽  
Protein Structures ◽  
Cell Receptor ◽  
Industrial Applications ◽  
Biofuel Production ◽  
Homologous Proteins ◽  
Related Proteins

Abstract Evolutionarily related proteins can present similar structures but very dissimilar sequences. Hence, understanding the role of the inter-residues contacts for the protein structure has been the target of many studies. Contacts comprise non-covalent interactions, which are essential to stabilize macromolecular structures such as proteins. Here we show VTR, a new method for the detection of analogous contacts in protein pairs. VTR performs structural alignment between proteins and detects interactions that occur in similar regions. To evaluate our tool, we proposed three case studies: (i) we compared a vertebrate myoglobin and a truncated invertebrate hemoglobin; (ii) analyzed interactions between the spike protein RBD of SARS-CoV-2 and the cell receptor ACE2; and (iii) compared a glucose-tolerant and a non-tolerant β-glucosidase enzyme used for biofuel production. The case studies demonstrate the potential of VTR for the understanding of functional similarities between distantly sequence-related proteins, as well as the exploration of important drug targets and rational design of enzymes for industrial applications. We envision VTR as a promising tool for understanding differences and similarities between homologous proteins with similar 3D structures but different sequences. VTR is available at http://bioinfo.dcc.ufmg.br/vtr.

scholarly journals On the kinematics and synthesis of a geared five-bar slider–crank mechanism

2011 ◽  
Vol 225 (5) ◽  
pp. 1253-1261 ◽  
Author(s):  
I A Sultan ◽  
A Kalim
Keyword(s):  
Mathematical Model ◽  
Case Studies ◽  
Optimization Procedure ◽  
Industrial Applications ◽  
Levenberg Marquardt ◽  
Gradient Based ◽  
Motion Characteristics ◽  
Crank Mechanism

The geared five-bar mechanism possesses kinematic abilities that qualify its utility in various industrial applications. Small changes to the mechanism topology or dimensions create new designs with different motion characteristics. This article presents design-orientated kinematical insights and mathematical treatments for the embodiment of the mechanism in which the end gear is eccentrically pivoted to a sliding element. For its synthesis, a kinematic classification is introduced and approximate curves are used to guide the motion of the slider. A gradient-based Levenberg–Marquardt formulation is employed for the optimization procedure. Geometric, mobility, and dimensional constraints are utilized together with numerical position equations for the analysis. Two case studies are presented at the end of this article to highlight the versatility of the mechanism and prove the validity of the presented mathematical model.

scholarly journals A systems approach for forward and reverse logistics design

2016 ◽  
Vol 27 (3) ◽  
pp. 947-971 ◽  
Author(s):  
Ayham A.M. Jaaron ◽  
Chris Backhouse
Keyword(s):  
Case Studies ◽  
Design Process ◽  
Reverse Logistics ◽  
Systems Approach ◽  
Industrial Applications ◽  
Three Dimensions ◽  
Content Type ◽  
Information Demand ◽  
Logistics Services ◽  
Exploratory Case Studies

Purpose There is significant potential for adding value by involving customer in the design process and delivery of logistic services. In order to add value to the overall logistic system, the purpose of this paper is to apply an integrated systems approach for the design of forward and reverse logistics services in order to build a self-organising service that can maximise efficiencies and in particular reduce reverse logistics costs. Design/methodology/approach Two exploratory case studies were conducted in the logistics systems of housing repair and maintenance sector in the UK. Data were collected using semi-structured interviews, observations, and documented evidence. Findings The findings of the cross-case analysis suggests that systems approach expressed as the Vanguard Method (Seddon, 2008) has a direct impact on enhancing forward logistics performance and reducing reverse product flows by nourishing three dimensions for learning from demand-driven analysis; capturing customer clean information, demand predictability and categorisation, and failure demand analysis. Research limitations/implications Findings from exploratory case studies cannot be easily generalised. Hence, further case studies are needed to enrich the findings, and to facilitate their industrial applications. Further, the paper explores the utilisation of the Vanguard Method only in the area of housing repairs and maintenance logistics services. It would be valuable for future studies to further investigate the utilisation of the Vanguard Method in other logistics services settings. Originality/value The paper demonstrates an important dynamics of how logistics services can incorporate customer demands into the logistics design process.

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