Complications of Systemic Analgesic Drugs

2021 ◽  
pp. 109-117
Author(s):  
Maria Amengual‐Vila ◽  
Eva Rioja Garcia
Keyword(s):  
Analgesic Drugs

Potentiation of Ethanol-Induced Depression in Dogs by Representative Ataractic and Analgesic Drugs

1963 ◽  
Vol 24 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Robert B. Forney ◽  
Francis W. Hughes ◽  
Harold R. Hulpieu
Keyword(s):  
Analgesic Drugs

Lifestyle and Peptic Ulcer Disease

2018 ◽  
Vol 24 (18) ◽  
pp. 2034-2040 ◽  
Author(s):  
Berrak C. Yegen
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Alcohol Intake ◽  
Night Sleep ◽  
Unhealthy Lifestyle ◽  
Coping With Stress ◽  
Analgesic Drugs ◽  
Ulcer Disease ◽  
Balanced Diet ◽  
H Pylori

The risk of developing Peptic Ulcer Disease (PUD) was shown to be associated with genetic inheritance, lifestyle and social status of the patients. Unhealthy lifestyle habits and failure in coping with stress have been closely associated with the occurrence of PUD. In contrary, limiting the use of analgesic drugs and glucocorticoids, controlling environmental and socioeconomic factors that predispose to H. Pylori infection, having a balanced diet, exercising regularly, coping successfully with stress, avoiding smoking, limiting alcohol intake and getting sufficient night sleep are essential in prevention and healing of PUD.

Chemometric Analysis for the Classification of some Groups of Drugs with Divergent Pharmacological Activity on the Basis of some Chromatographic and Molecular Modeling Parameters

2018 ◽  
Vol 21 (2) ◽  
pp. 125-137
Author(s):  
Jolanta Stasiak ◽  
Marcin Koba ◽  
Marcin Gackowski ◽  
Tomasz Baczek
Keyword(s):  
Correlation Analysis ◽  
Pharmacological Activity ◽  
Correlation Coefficients ◽  
Principal Component ◽  
Cardiovascular Drugs ◽  
New Drugs ◽  
Analgesic Drugs ◽  
Starting Point ◽  
Chromatographic Parameters

Aim and Objective: In this study, chemometric methods as correlation analysis, cluster analysis (CA), principal component analysis (PCA), and factor analysis (FA) have been used to reduce the number of chromatographic parameters (logk/logkw) and various (e.g., 0D, 1D, 2D, 3D) structural descriptors for three different groups of drugs, such as 12 analgesic drugs, 11 cardiovascular drugs and 36 “other” compounds and especially to choose the most important data of them. Material and Methods: All chemometric analyses have been carried out, graphically presented and also discussed for each group of drugs. At first, compounds’ structural and chromatographic parameters were correlated. The best results of correlation analysis were as follows: correlation coefficients like R = 0.93, R = 0.88, R = 0.91 for cardiac medications, analgesic drugs, and 36 “other” compounds, respectively. Next, part of molecular and HPLC experimental data from each group of drugs were submitted to FA/PCA and CA techniques. Results: Almost all results obtained by FA or PCA, and total data variance, from all analyzed parameters (experimental and calculated) were explained by first two/three factors: 84.28%, 76.38 %, 69.71% for cardiovascular drugs, for analgesic drugs and for 36 “other” compounds, respectively. Compounds clustering by CA method had similar characteristic as those obtained by FA/PCA. In our paper, statistical classification of mentioned drugs performed has been widely characterized and discussed in case of their molecular structure and pharmacological activity. Conclusion: Proposed QSAR strategy of reduced number of parameters could be useful starting point for further statistical analysis as well as support for designing new drugs and predicting their possible activity.

Opioid-free anaesthesia for the surgical correction of abnormalities associated with brachycephalic obstructive airway syndrome in five dogs

2021 ◽  
Vol 26 (3) ◽  
pp. 57-61
Author(s):  
María Isabel Gómez Martínez ◽  
Miguel Ángel Martínez Fernández
Keyword(s):  
Side Effects ◽  
Nerve Block ◽  
Opioid Analgesic ◽  
Multimodal Analgesia ◽  
Human Medicine ◽  
Surgical Correction ◽  
Analgesic Drugs ◽  
Maxillary Nerve ◽  
Nociceptive Pathways ◽  
Maxillary Nerve Block

Opioid-free anaesthesia is currently becoming more popular in human medicine, as it provides multimodal analgesia, affecting multiple nociceptive pathways without the use of opioids, in order to minimise opioid-related side effects. This article presents the cases of five dogs undergoing surgical correction of abnormalities associated with brachycephalic obstructive airway syndrome, all of whom received opioid-free anaesthesia for surgery. All dogs received a bilateral maxillary nerve block with bupivacaine 0.5% and a combination of non-opioid analgesic drugs. Buprenorphine was allowed during the postoperative period, based on pain assessment. Three out of five dogs received buprenorphine 6–7 hours after the nerve block was performed. Opioid-free anaesthesia provided adequate conditions for surgery and no adverse effects were reported. Prospective controlled studies comparing opioid-free anaesthesia with opioid-based techniques are required to elucidate whether or not opioid-free anaesthesia confers objective advantages.

An Approach to Pain in Research Animals

1988 ◽  
Vol 16 (2) ◽  
pp. 145-154
Author(s):  
David B. Adams
Keyword(s):  
Tissue Damage ◽  
Effective Means ◽  
Physical Pain ◽  
Insufficient Information ◽  
Experimental Procedure ◽  
Analgesic Drugs ◽  
Diagnosis And Prognosis ◽  
Experimental Subjects ◽  
Decisive Action ◽  
Cause Of Pain

Pain can either signal the threat of tissue-damage (nociception) or can result from tissue damage itself. The physiology and “pathology” of pain, in the second instance, suggest that it can be diagnosed (not “measured”, “assessed”, etc.) on the basis of its association, but not equality, with tissue damage and by its coincidence with changes in behaviour. Pain will be present as part of a syndrome and cannot occur without cause or association. Pain may occur in experiments: a) coincidentally and unrelated to any experimental procedure, b) accidentally, when a procedure goes amiss, and c) as part of the experimental design. Where pain is intrinsic to the aims of an experiment (for example in the testing of analgesics), “escape routes” and “limits” must be formulated for the benefit of experimental subjects. In addition, the empirical value of the experiment must be assessed. There is insufficient information on the use and efficacy of analgesic drugs in animals. These drugs, however, are neither the only nor the most effective means of alleviating physical pain in animals. Other forms of treatment are considered. All depend on sound diagnosis and prognosis. Decisive action against the cause of pain is necessary.

scholarly journals Lost but making progress--Where will new analgesic drugs come from?

2014 ◽  
Vol 6 (249) ◽  
pp. 249sr3-249sr3 ◽  
Author(s):  
D. Borsook ◽  
R. Hargreaves ◽  
C. Bountra ◽  
F. Porreca
Keyword(s):  
Analgesic Drugs
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