Clinical Utility of Clozapine in Bipolar Disorder

2011 ◽  
pp. 131-152
Author(s):  
V. E. Cosgrove ◽  
J. S. Seo ◽  
H. Yang ◽  
Trisha Suppes
Keyword(s):  
Bipolar Disorder ◽  
Clinical Utility

scholarly journals Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder

2017 ◽  
Vol 2017 ◽  
pp. 1-37 ◽  
Author(s):  
Cristy Phillips
Keyword(s):  
Physical Activity ◽  
Bipolar Disorder ◽  
Mood Disorders ◽  
Biogenic Amine ◽  
Clinical Utility ◽  
Major Depressive ◽  
Positive Effects ◽  
Mental Diseases

Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers.

scholarly journals Staging in bipolar disorder: from theoretical framework to clinical utility

2017 ◽  
Vol 16 (3) ◽  
pp. 236-244 ◽  
Author(s):  
Michael Berk ◽  
Robert Post ◽  
Aswin Ratheesh ◽  
Emma Gliddon ◽  
Ajeet Singh ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Clinical Utility ◽  
Theoretical Framework

scholarly journals Exploring the clinical utility of two staging models for bipolar disorder

2019 ◽  
Vol 22 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Afra Markt ◽  
Ursula M. H. Klumpers ◽  
Annemiek Dols ◽  
Stasja Draisma ◽  
Marco P. Boks ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Clinical Utility

Clinical utility of pharmacogenetic testing in the treatment of bipolar disorder of Chinese patients

2020 ◽  
Vol 21 (11) ◽  
pp. 761-770
Author(s):  
Xu Huilei ◽  
Chen Siyu ◽  
Xu Jianghua ◽  
Ren Jidong ◽  
Ren Yi
Keyword(s):  
Bipolar Disorder ◽  
Side Effects ◽  
Clinical Global Impression ◽  
Chinese Population ◽  
Clinical Utility ◽  
Chinese Patients ◽  
Traditional Treatment ◽  
Pharmacogenetic Testing ◽  
Efficacy Index

Aim: The purpose of this study was to evaluate the clinical utility of pharmacogenetic (PGx) testing in the treatment of bipolar disorder in the Chinese population. Patients & methods: Compare efficacy and side effects, measured by the Clinical Global Impression Efficacy Index scale (CGI-EI), of PGx-guided treatment (n = 100) to that of the traditional treatment (n = 100). Results: Compared with the traditional treatment, PGx-guided treatment reduced the number of medications used for patients, also achieving better efficacy at 4, 8 and 12 weeks. In the analysis of side effects, the PGx-guided group significantly reduced the side effects. Conclusion: Our study suggests that PGx testing results-guided treatment is superior to the traditional treatment of bipolar disorder in the Chinese population.

Type V Bekesy Pattern: Interpretation and Clinical Utility

1967 ◽  
Vol 10 (4) ◽  
pp. 733-744 ◽  
Author(s):  
William F. Rintelmann ◽  
Earl R. Harford
Keyword(s):  
Clinical Utility ◽  
The Past ◽  
Type V ◽  
Clinical Cases

Recent studies indicate there is some disagreement concerning the interpretation and clinical utility of the Type V Bekesy pattern. Bekesy tracings obtained over the past six years from a sample of clinical cases were analyzed and a definition was established for the Type V pattern. This definition was applied to Bekesy tracings obtained from normal listeners, hypoacusics, and pseudohypoacusics. The Type V pattern was found frequently among pseudohypoacusics and only rarely among other individuals.

“I Can See What You’re Saying”: Clinical Utility of Spectral Moment Analysis

2011 ◽  
Vol 21 (2) ◽  
pp. 44-54
Author(s):  
Kerry Callahan Mandulak
Keyword(s):  
Speech Production ◽  
Speech Signal ◽  
Clinical Utility ◽  
Acoustic Analysis ◽  
Moment Analysis ◽  
Analysis Tool ◽  
Spectral Moment ◽  
Clinical Measure ◽  
Perceptual Analysis ◽  
Disordered Speech

Spectral moment analysis (SMA) is an acoustic analysis tool that shows promise for enhancing our understanding of normal and disordered speech production. It can augment auditory-perceptual analysis used to investigate differences across speakers and groups and can provide unique information regarding specific aspects of the speech signal. The purpose of this paper is to illustrate the utility of SMA as a clinical measure for both clinical speech production assessment and research applications documenting speech outcome measurements. Although acoustic analysis has become more readily available and accessible, clinicians need training with, and exposure to, acoustic analysis methods in order to integrate them into traditional methods used to assess speech production.

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