Near-Infrared In Vivo Spectroscopic Imaging: Biomedical Research and Clinical Applications

2011 ◽  
pp. 149-165 ◽  
Author(s):  
R. Anthony Shaw ◽  
Valery V. Kupriyanov ◽  
Olga Jilkina ◽  
Michael G. Sowa
Keyword(s):  
Biomedical Research ◽  
Near Infrared ◽  
Spectroscopic Imaging ◽  
Clinical Applications

A time-gated near-infrared spectroscopic imaging device for clinical applications.

2013 ◽  
Author(s):  
Patrick Poulet ◽  
Wilfried Uhring ◽  
Walter Hanselmann ◽  
René Glazenborg ◽  
Farouk Nouizi ◽  
...  
Keyword(s):  
Near Infrared ◽  
Spectroscopic Imaging ◽  
Clinical Applications ◽  
Imaging Device ◽  
Infrared Spectroscopic ◽  
Infrared Spectroscopic Imaging

Utilization of in vivo ultrafiltration in biomedical research and clinical applications

Life Sciences ◽  
2003 ◽  
Vol 73 (16) ◽  
pp. 2005-2018 ◽  
Author(s):  
Gea Leegsma-Vogt ◽  
Elsa Janle ◽  
Stephen R Ash ◽  
Kor Venema ◽  
Jakob Korf
Keyword(s):  
Biomedical Research ◽  
Clinical Applications

Long-wavelength near-infrared spectroscopic imaging for in-vivo skin hydration measurements

2002 ◽  
Vol 28 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Michael Attas ◽  
Trevor Posthumus ◽  
Bernie Schattka ◽  
Michael Sowa ◽  
Henry Mantsch ◽  
...  
Keyword(s):  
Near Infrared ◽  
Spectroscopic Imaging ◽  
Skin Hydration ◽  
Long Wavelength ◽  
Infrared Spectroscopic ◽  
Infrared Spectroscopic Imaging

A Novel TMTP1-Modified Theranostic Nanoplatform for Targeted In Vivo NIR-II Fluorescence Imaging-Guided Chemotherapy of Cervical Cancer

2022 ◽  
Author(s):  
Nuernisha Alifu ◽  
Rong Ma ◽  
Lijun Zhu ◽  
Zhong Du ◽  
Shuang Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Fluorescence Imaging ◽  
Spatial Resolution ◽  
Biomedical Research ◽  
Near Infrared ◽  
High Sensitivity ◽  
Research Fields ◽  
Excellent Spatial Resolution ◽  
Fluorescence Bioimaging

Near-infrared II (NIR-II, 900-1700 nm) fluorescence bioimaging with advantages of good biosafety, excellent spatial resolution, high sensitivity, and contrast has attracted great attentions in biomedical research fields. However, most of...

RAMAN SPECTROSCOPY FOR IN VIVO TISSUE ANALYSIS AND DIAGNOSIS, FROM INSTRUMENT DEVELOPMENT TO CLINICAL APPLICATIONS

2008 ◽  
Vol 01 (01) ◽  
pp. 95-106 ◽  
Author(s):  
HAISHAN ZENG ◽  
JIANHUA ZHAO ◽  
MICHAEL SHORT ◽  
DAVID I. MCLEAN ◽  
STEPHEN LAM ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Raman Spectra ◽  
Cancer Detection ◽  
Tissue Characterization ◽  
Near Infrared ◽  
Skin Diseases ◽  
Clinical Applications ◽  
Fiber Array ◽  
Raman Probe

Raman spectroscopy is a noninvasive, nondestructive analytical method capable of determining the biochemical constituents based on molecular vibrations. It does not require sample preparation or pretreatment. However, the use of Raman spectroscopy for in vivo clinical applications will depend on the feasibility of measuring Raman spectra in a relatively short time period (a few seconds). In this work, a fast dispersive-type near-infrared (NIR) Raman spectroscopy system and a skin Raman probe were developed to facilitate real-time, noninvasive, in vivo human skin measurements. Spectrograph image aberration was corrected by a parabolic-line fiber array, permitting complete CCD vertical binning, thereby yielding a 16-fold improvement in signal-to-noise ratio. Good quality in vivo skin NIR Raman spectra free of interference from fiber fluorescence and silica Raman scattering can be acquired within one second, which greatly facilitates practical noninvasive tissue characterization and clinical diagnosis. Currently, we are conducting a large clinical study of various skin diseases in order to develop Raman spectroscopy into a useful tool for non-invasive skin cancer detection. Intermediate data analysis results are presented. Recently, we have also successfully developed a technically more challenging endoscopic Laser-Raman probe for early lung cancer detection. Preliminary in vivo results from endoscopic lung Raman measurements are discussed.

20 Near-infrared (NIR) spectroscopic imaging of cardiac ischemia in the in vivo pigs

2002 ◽  
Vol 34 (7) ◽  
pp. A27
Author(s):  
Valery Kupriyanov ◽  
Stephen Rempel ◽  
Bo Xiang ◽  
John Rendell ◽  
Anthony Shaw ◽  
...  
Keyword(s):  
Near Infrared ◽  
Spectroscopic Imaging ◽  
Cardiac Ischemia

Spectroscopic imaging of human disease

1996 ◽  
Vol 54 ◽  
pp. 884-885
Author(s):  
D.J. Meyerhoff
Keyword(s):  
Magnetic Field ◽  
Magnetic Resonance ◽  
Field Gradient ◽  
Human Disease ◽  
Morphological Changes ◽  
Magnetic Field Gradient ◽  
Spectroscopic Imaging ◽  
Resonance Spectroscopy ◽  
Tissue Water

Magnetic Resonance Imaging (MRI) observes tissue water in the presence of a magnetic field gradient to study morphological changes such as tissue volume loss and signal hyperintensities in human disease. These changes are mostly non-specific and do not appear to be correlated with the range of severity of a certain disease. In contrast, Magnetic Resonance Spectroscopy (MRS), which measures many different chemicals and tissue metabolites in the millimolar concentration range in the absence of a magnetic field gradient, has been shown to reveal characteristic metabolite patterns which are often correlated with the severity of a disease. In-vivo MRS studies are performed on widely available MRI scanners without any “sample preparation” or invasive procedures and are therefore widely used in clinical research. Hydrogen (H) MRS and MR Spectroscopic Imaging (MRSI, conceptionally a combination of MRI and MRS) measure N-acetylaspartate (a putative marker of neurons), creatine-containing metabolites (involved in energy processes in the cell), choline-containing metabolites (involved in membrane metabolism and, possibly, inflammatory processes),

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